Test Price
2,800 AED✅ Home Collection Available
RNF128 Gene Autism Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
This clinically validated test sequences the entire RNF128 gene using next‑generation sequencing (NGS) to detect pathogenic and likely pathogenic variants linked to Autism Spectrum Disorder (ASD). With a diagnostic sensitivity exceeding 99.9% and an ISO‑accelerated turnaround of 3–4 weeks, the test is paired with mandatory pre‑test genetic counselling and a detailed molecular report interpreted by board‑certified medical geneticists. All procedures comply with UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability and the Dubai Health Authority (DHA) Facility license #1143.
Test Overview & Methodology
The RNF128 NGS panel covers all coding exons and canonical splice sites, with Sanger confirmation of all clinically significant variants. This approach provides superior diagnostic yield compared to targeted PCR, which focuses only on known hotspots. The test is performed at our ISO 9001:2015‑certified laboratory in Dubai Healthcare City.
| Feature | Our Test (RNF128 NGS) | Closest Alternative (Targeted PCR) |
|---|---|---|
| Precision | Whole‑gene coverage, 99.9% diagnostic sensitivity | Limited to known hotspots, ~85% sensitivity |
| Methodology | Next‑Generation Sequencing with Sanger confirmation | PCR + Sanger for selected exons |
| Turnaround Time | 3–4 Weeks (ISO‑accelerated) | 6–8 Weeks |
Pre‑Test Requirement: All patients (or legal guardians) must attend a comprehensive genetic counselling session to construct a pedigree chart of family members affected with autism and RNF128‑related disorders. This step is mandatory under UAE genetic testing regulations and ensures accurate interpretation of your results.
Physician Insight & Safety Protocols
“Having dedicated my career to medical genetics, I understand the profound impact a precise molecular diagnosis can have on a family’s journey. This RNF128 NGS panel provides high‑resolution clarity for autism spectrum disorders, but it must always be integrated with a comprehensive clinical work‑up and multidisciplinary support. No single gene defines a child’s potential.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
⚠ Medication & Therapy Advisory
Important Safety Notice: Do not discontinue or alter any prescribed medication, behavioural therapy, or dietary intervention without direct instruction from your treating physician. This genetic test is intended for diagnostic clarification and risk assessment only; it does not replace clinical judgment.
Exclusion Criteria & Red Flags
- Individuals with untreated or uncontrolled seizure disorders or acute neurological deterioration requiring hospitalisation.
- Children under 1 year unless specifically referred by a paediatric neurologist.
- Severe behavioural instability that could pose a risk during home blood collection.
- Red Flags: Seek immediate emergency care if the patient experiences sudden loss of speech, developmental regression, or new‑onset seizures.
Patient FAQ & Clinical Guidance
1. What does the RNF128 genetic test diagnose?
This test sequences the RNF128 gene to detect pathogenic variants strongly associated with autism spectrum disorder, aiding diagnosis and family risk assessment. Our NGS method covers all coding exons and canonical splice sites, delivering a definitive molecular result within 3–4 weeks. A DHA‑licensed genetic counsellor will explain both pre‑test implications and post‑test findings.
2. Does the test require special consent for minors in the UAE?
Yes, under UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability and the DHA guidelines, written informed consent from a parent or legal guardian is mandatory for minors. A pre‑test genetic counselling session is also required to ensure the family understands the purpose, risks, and implications of testing. All consent documentation is maintained in compliance with data protection laws.
3. How is the sample collected and what is the turnaround time?
A certified phlebotomist collects a small blood sample or a single drop on an FTA card at your home between 8 AM and 11 PM, transported under cold‑chain to our ISO‑certified lab. Results are released in 3–4 weeks. The report includes variant classification (pathogenic, likely pathogenic, VUS) and a complimentary telehealth session with a medical geneticist to guide next steps.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Security: This genetic test fully complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All personal health information is encrypted during transmission and storage, and only authorised clinical personnel have access. Clinical governance is ensured under Federal Decree‑Law No. 4 of 2016 on Medical Liability, which mandates informed consent and patient safety for all diagnostic procedures.
Clinical & Logistical Metadata
| Test Name | RNF128 Gene (Autism) – Next‑Generation Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) or dried blood spot (FTA card) – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM) |
| Methodology Used | Next‑Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | F84.0 (Autistic disorder), Z13.858 (Encounter for screening for other nervous system disorders), Z15.89 (Genetic susceptibility to other disease) |
| LOINC Code | 82939-0 (Genetic analysis panel – blood or tissue by Sequencing) |
| DHA Facility License & Lab Address | DHA Facility License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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