Test Price
2,800 AED✅ Home Collection Available
RET Gene Hirschsprung Disease Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS-based wet-bench processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary telephonic post-test clinical guidance with a DHA-licensed genetic counsellor to interpret results in the context of your family’s health history.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731; we verify your coverage before collection.
Test Overview & Methodology
The RET gene NGS test analyses the entire coding sequence of the RET proto‑oncogene to identify pathogenic variants responsible for Hirschsprung disease (HSCR) and associated endocrine tumour syndromes. This comprehensive analysis screens all coding exons and splice‑site regions, revealing not only classic HSCR variants but also variants predisposing to multiple endocrine neoplasia type 2 (MEN2).
| Feature | Our Test (Genomic‑Grade NGS) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | 99.9% sensitivity; full exon coverage with 200× depth | ~92% detection; may miss large deletions |
| Method | Next Generation Sequencing (Illumina NovaSeq X) | Sanger sequencing of selected exons |
| Turnaround | 3–4 Weeks | 6–8 Weeks |
Physician Insight & Safety Protocols
“Molecular diagnosis of RET‑associated disease is a powerful step, but it must always be integrated with thorough clinical evaluation. A positive RET variant indicates risk, not inevitability; a negative result does not exclude the diagnosis if clinical suspicion remains high. I advise all patients and families to discuss their results with a paediatric geneticist before making any treatment decisions.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory – Medication & Clinical Management
Important Medication Advisory
Do not alter or discontinue prescribed therapies without consulting your physician. This genetic test provides risk information; it does not replace ongoing clinical management or emergency care for Hirschsprung disease complications.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active infection at venipuncture site, severe anaemia (Hb < 7 g/dL), inability of the legal guardian to provide informed consent (mandatory for minors under Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Emergency Red Flags: If you develop persistent bleeding, expanding haematoma, or signs of infection (fever, redness) at the collection site, seek immediate medical attention at the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the RET gene NGS test for Hirschsprung disease?
RET gene NGS testing identifies mutations in the RET proto‑oncogene linked to Hirschsprung disease with over 99.9% analytical sensitivity. This comprehensive analysis screens all coding exons and splice‑site regions, revealing not only classic HSCR variants but also variants predisposing to multiple endocrine neoplasia type 2 (MEN2). The result helps paediatric surgeons and oncologists tailor management, including prophylactic thyroidectomy when a high‑risk RET mutation is found.
2. How is the sample collected and what is the turnaround time?
A certified phlebotomist visits your home or office between 8 AM and 11 PM to collect a whole blood sample in a dedicated DNA FTA card or EDTA tube, which is immediately cold‑chain transported to our ISO‑accredited laboratory. Once the sample arrives, Next Generation Sequencing is performed, and results are rigorously bioinformatically interpreted. The standard reporting time is 3 to 4 weeks, enabling timely multidisciplinary planning.
3. Are the results accepted by UAE healthcare authorities and insurance?
Yes, all reports are issued under DHA Facility License Number 1143 from DNA Labs UAE and comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. We provide fully documented LOINC-coded results (21687-8) and ICD-10-CM diagnostic codes (Q43.1, Z15.01, Z14.8), ensuring seamless recognition by DHA-regulated hospitals and direct insurance billing. Our genetic counsellor also helps you understand the implications for family screening.
UAE Regulatory & Data Privacy Adherence
This test is performed in accordance with UAE medical laboratory standards under DHA Facility License Number 1143. All genetic data is protected under Federal Decree-Law No. 45 of 2021 (PDPL) and Federal Law No. 2 of 2019. Results must be interpreted by a qualified physician. For urgent medical concerns, contact your doctor or call emergency services immediately.
Clinical & Logistical Metadata
| Test Name | RET Gene Hirschsprung Disease Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood (EDTA or FTA card) |
| Methodology Used | Next Generation Sequencing (NGS) – Illumina NovaSeq X |
| ICD-10-CM Code | Q43.1, Z15.01, Z14.8 |
| LOINC Code | 21687-8 |
| DHA Facility License & Laboratory Address | License: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians