Test Price
2,800 AED✅ Home Collection Available
RAG2 Gene Combined Cellular and Humoral Immune Defects with Granulomas Genetic Test in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين RAG2 للكشف عن العيوب المناعية الخلوية والخلطية المركبة المصحوبة بالأورام الحبيبية بتقنية التسلسل الجيني من الجيل التالي (NGS) في دولة الإمارات | 2,800 درهم إماراتي | معتمد من هيئة الصحة بدبي
Executive Summary | ملخص تنفيذي
يقدم هذا الفحص الجيني الشامل تقييماً متكاملاً لجين RAG2 باستخدام تقنية التسلسل الجيني من الجيل التالي للكشف عن الطفرات المسببة للعيوب المناعية الخلوية والخلطية المركبة المصحوبة بالأورام الحبيبية. نضمن دقة تشخيصية تصل إلى 99.9% من خلال مختبراتنا المعتمدة دولياً وفق معايير ISO 9001:2015 وتحت إشراف هيئة الصحة بدبي. تشمل خدماتنا المتميزة خدمة السحب المنزلي المعتمدة للمستشفيات مع النقل المبرد وفق أعلى المعايير، والاستشارة الوراثية الهاتفية بعد ظهور النتائج، والتحقق المباشر من التغطية التأمينية عبر تطبيق واتساب.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO-Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed genetic counsellors.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Clinical Overview
The RAG2 Gene Genetic Test is a high-resolution diagnostic assay that screens the entire coding region of the Recombination Activating Gene 2 (RAG2) using Next-Generation Sequencing technology to identify pathogenic variants linked to combined cellular and humoral immune deficiencies with granulomatous manifestations. يكتشف هذا الفحص الطفرات الجينية في جين RAG2 المسؤولة عن اضطرابات نقص المناعة المشترك المصحوب بأورام حبيبية جلدية وجهازية. Designed for clinical diagnostic workup, family screening, and research applications, this test delivers definitive molecular confirmation with a turnaround time of 3 to 4 weeks at a cost of 2,800 AED.
| Feature | Our Test – RAG2 NGS (DHA-Licensed) | Closest Alternative – Single-Gene Sanger Sequencing |
|---|---|---|
| Methodology | NGS (Next-Generation Sequencing) – Full gene coverage including deep intronic regions | Sanger Sequencing – Limited to targeted exonic regions only |
| Diagnostic Sensitivity | 99.9% – Detects SNVs, indels, and copy number variants | ~95% – May miss large deletions, mosaicism, and deep intronic variants |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
| UAE Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | DHA Facility License: 9834453 | Variable; may lack UAE-specific regulatory approval |
| Post-Test Support | Telephonic Clinical Guidance + Genetic Counselling Referral | Often limited to written report only |
Physician Insight & Safety Protocol
"As a clinician with extensive experience in immunogenetics, I emphasize that the RAG2 NGS test provides invaluable molecular confirmation for suspected combined immunodeficiency syndromes. However, a positive genetic finding must always be correlated with the patient's clinical phenotype, immunological laboratory parameters, and family history before establishing a definitive diagnosis. I strongly advise all patients and families to engage in pre-test and post-test genetic counselling to fully understand the implications of the results."
— Dr. PRABHAKAR REDDY, DHA License No. 61713011
Clinical Notice: Do not discontinue any prescribed medication, including immunosuppressants, corticosteroids, or antimicrobial prophylaxis, without consulting your treating physician. Genetic test results do not replace ongoing clinical management, and abrupt medication cessation may precipitate severe disease flares or life-threatening infections in immunocompromised individuals.
Safety Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed If)
- Patient has received a blood transfusion within the last 14 days (may confound germline DNA analysis).
- Patient is currently hospitalized for an active severe systemic infection (defer testing until clinically stable).
- Minors without valid parental or legal guardian consent as mandated by UAE CDS Law 2026.
- Inability to provide informed consent for genetic testing per UAE PDPL data privacy regulations.
- Patient is on experimental gene therapy that may alter native DNA signatures (consult laboratory before collection).
Emergency Red Flags – Seek Immediate Medical Attention
- Fever exceeding 38.5°C persisting beyond 24 hours, especially with rigors or confusion.
- Rapidly progressive skin lesions with ulceration, necrosis, or purulent discharge.
- Respiratory distress — shortness of breath, chest pain, or oxygen saturation below 92%.
- Signs of severe combined immunodeficiency: failure to thrive in infants, persistent oral thrush, or recurrent invasive infections.
- Acute abdominal pain with distension, potentially indicating granulomatous enterocolitis.
Pre-Test Requirements & Genetic Counselling
Prior to sample collection, patients must provide a detailed clinical history documenting any prior immune deficiency diagnoses, recurrent infections, granulomatous skin lesions, or family history of primary immunodeficiency. A mandatory Genetic Counselling session is required to construct a comprehensive pedigree chart identifying family members affected by RAG2 gene-related combined cellular and humoral immune defects. This session ensures informed consent and prepares patients for the potential clinical and familial implications of the test results, in full compliance with UAE PDPL and Federal Decree-Law No. 41 of 2024 (Art. 87) governing genetic data privacy.
Accepted Sample Types: Whole Blood (EDTA tube), Extracted DNA (minimum 1 µg), or One Drop of Blood on FTA Card. All samples are transported via ISO-certified cold-chain logistics at 2–8°C.
Patient FAQ & Clinical Guidance
Q: What is the RAG2 gene and why is this NGS test clinically important for my health?
Snippet: RAG2 Genetic Testing identifies disease-causing mutations in the RAG2 gene linked to combined immunodeficiency with granulomas.
This test provides a definitive molecular diagnosis by analyzing the full coding sequence of the RAG2 gene, which encodes a critical enzyme for V(D)J recombination essential for adaptive immune system development. Pathogenic variants in RAG2 disrupt both T-cell and B-cell maturation, leading to a spectrum of disorders ranging from severe combined immunodeficiency (SCID) to Omenn syndrome and combined cellular and humoral immune defects with granulomatous inflammation affecting the skin, bones, and internal organs. Identifying the specific mutation guides targeted clinical management, hematopoietic stem cell transplant eligibility, and family planning decisions.
يوفر هذا الفحص تشخيصاً جزيئياً دقيقاً من خلال تحليل التسلسل الكامل لجين RAG2 المسؤول عن تطور الجهاز المناعي التكيفي. الطفرات الممرضة في هذا الجين تؤدي إلى اضطرابات نقص المناعة المشترك ومتلازمة أومين والتهابات حبيبية مزمنة تتطلب تدخلاً طبياً متخصصاً.
Q: How is the sample collected and what is the turnaround time for receiving results?
Snippet: A single blood draw via hospital-grade home phlebotomy with ISO-certified cold-chain transport ensures safe sample delivery.
Our DHA-licensed phlebotomy team performs sample collection at your home, hospital, or clinic between 8:00 AM and 11:00 PM, seven days a week. The procedure requires only a standard venous blood draw (3–5 mL in an EDTA tube), a buccal swab, or a single drop of blood applied to an FTA card for DNA stabilization. Samples are immediately placed in ISO-certified temperature-controlled transport containers and delivered to our molecular diagnostics laboratory. The complete NGS workflow — including library preparation, sequencing, bioinformatics analysis, and clinical interpretation — requires 3 to 4 weeks. Results are released through our secure patient portal with an option for telephonic clinical guidance.
يتم جمع العينة عن طريق سحب دم وريدي بسيط في المنزل أو المستشفى بواسطة فريق تمريض مرخص من هيئة الصحة بدبي، مع نقل العينة في حاويات مبردة معتمدة وفق معايير ISO إلى مختبرنا المتخصص. تستغرق النتائج من 3 إلى 4 أسابيع.
Q: What do my results mean and who will explain them to me?
Snippet: Pathogenic RAG2 variants indicate combined immunodeficiency risk, with expert clinical guidance provided for result interpretation and management planning.
Your report will categorize identified variants according to ACMG/AMP 2026 guidelines as Pathogenic, Likely Pathogenic, Variant of Uncertain Significance (VUS), Likely Benign, or Benign. A positive finding (Pathogenic or Likely Pathogenic variant) confirms a molecular diagnosis of RAG2-related immunodeficiency and should prompt immediate referral to a clinical immunologist for management planning, which may include immunoglobulin replacement therapy, antimicrobial prophylaxis, or evaluation for hematopoietic stem cell transplantation. A DHA-licensed genetic counsellor will provide a dedicated telephonic consultation to explain your results in clear, actionable terms, address your concerns, and coordinate follow-up care with your referring physician. Family cascade testing is recommended for all first-degree relatives of mutation-positive individuals.
يتم تصنيف النتائج وفقاً لإرشادات ACMG/AMP 2026 إلى طفرات ممرضة أو محتملة الإمراض أو غير محددة الأهمية. يقدم مستشار وراثي مرخص من هيئة الصحة بدبي استشارة هاتفية شاملة لشرح النتائج وتنسيق الرعاية الطبية اللاحقة مع طبيبك المعالج.
UAE Regulatory Compliance & Accreditation
- Federal Decree-Law No. 41 of 2024 (Art. 87): All genetic testing and genomic data handling strictly adhere to UAE federal mandates on genetic privacy, informed consent, and data sovereignty.
- CDS Law 2026 (Minors): Genetic testing of minors requires documented parental or legal guardian consent with mandatory pre-test genetic counselling, in full compliance with UAE child protection statutes.
- UAE PDPL (Personal Data Protection Law): Patient genomic data is encrypted, stored on secure servers within UAE jurisdiction, and never shared with third parties without explicit written authorization.
- ISO 9001:2015 Certification: Our laboratory holds active ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139), ensuring internationally recognized quality management systems for diagnostic accuracy and operational excellence.
- DHA Facility License: 9834453 — Licensed and audited by the Dubai Health Authority.
Schedule Your RAG2 Gene NGS Today
Home Collection Available 8:00 AM – 11:00 PM | Results in 3–4 Weeks | 2,800 AED
WhatsApp: +971 54 548 8731 | DHA License: 9834453
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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