Test Price
2,800 AED✅ Home Collection Available
RAG1 Gene (Severe Combined Immunodeficiency, B‑cell Negative) Genetic Test in UAE 2,800 AED | DHA Licensed & ISO 9001:2015 Certified
Executive Summary & Core Metrics
Test Overview & Methodology
The RAG1 gene NGS test detects pathogenic variants causing severe combined immunodeficiency (SCID) with absent B cells, a life‑threatening disorder where affected children lack functional lymphocytes. Early molecular diagnosis is critical for lifesaving interventions like haematopoietic stem cell transplantation. This test screens the entire RAG1 gene for DNA sequence variants and deletions that abolish the protein’s ability to rearrange immune receptor genes, causing SCID.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision / Coverage | Full RAG1 gene NGS + CNV analysis, 100% coding exons, Sanger confirmation | Targeted mutation panel (limited set of known variants) |
| Methodology | Next‑Generation Sequencing (NGS) – 2026 standard | Sanger sequencing or array‑based screening |
| Turnaround Time | 3‑4 weeks (comprehensive analysis) | 4‑6 weeks (often without CNV detection) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403): “No parent should face a SCID diagnosis alone — this test gives families the clarity to pursue early curative therapies. We combine genetic precision with a compassionate approach to interpret your child’s result, always correlating with clinical findings.”
Important Safety Advisory
⚠️ Do not discontinue any prescribed medication, especially immunoglobulin replacement or prophylactic antibiotics, without explicit instruction from your treating physician.
This test is intended for individuals with clinical suspicion of SCID or a known family history of RAG1-related disorders. Results must be reviewed by a clinical geneticist or immunologist; variants of uncertain significance require family segregation studies.
Exclusion Criteria & Precautions
- Exclusion Criteria: Asymptomatic individuals with no family history or clinical suspicion; test not for general newborn screening.
- Paediatric Consent: Mandatory signed parental/guardian consent per UAE Federal Law No. 2 of 2019 (minors).
- ER Red Flags: Fever ≥38.5 °C, new rash with respiratory distress, or lethargy in a child suspected of SCID — seek emergency care immediately.
- Interpretation Requirement: Results must be reviewed by a clinical geneticist or immunologist; variants of uncertain significance require family segregation studies.
Patient FAQ & Clinical Guidance
1. What exactly does the RAG1 gene test look for?
This test screens the entire RAG1 gene for DNA sequence variants and deletions that abolish the protein’s ability to rearrange immune receptor genes, causing SCID. It detects single nucleotide changes, small insertions/deletions, and copy number imbalances, all of which can lead to B‑cell‑negative severe combined immunodeficiency, a condition presenting in infancy with recurrent infections and failure to thrive.
2. Why does the result take 3 to 4 weeks?
Turnaround time of 3‑4 weeks reflects the meticulous steps of DNA extraction, NGS library preparation, sequencing, bioinformatic analysis, and confirmatory Sanger validation. Every variant is cross‑referenced against the latest ClinVar and gnomAD databases, and each report is manually reviewed by a PhD molecular geneticist to ensure the highest diagnostic accuracy before release to your referring physician.
3. Can I book a home visit for my baby?
Yes, our paediatric‑trained phlebotomists perform hospital‑grade home collection for babies and children, using a small‑volume EDTA tube or a painless FTA card spot. The sample is immediately placed in a validated cold‑chain transport and sent to our ISO‑certified genomics lab; you can schedule via WhatsApp (+971 54 548 8731) from 8 AM to 11 PM daily, and we coordinate with your health insurance directly.
4. What preparations are needed before the test?
A detailed clinical history questionnaire must be completed, including any known affected family members and consanguinity status. Mandatory pre‑test genetic counselling session to draw a pedigree chart of family members affected by SCID or RAG1‑related disorders. Do NOT stop any current medications, including immunoglobulin infusions or prophylactic antibiotics, without physician advice.
5. How do I arrange insurance pre‑authorisation?
WhatsApp a copy of your insurance card to +971 54 548 8731; we verify coverage and handle direct billing where approved. For minor patients, a signed consent form from both parents/legal guardians is required under UAE Federal Law No. 2 of 2019; a copy of the child’s Emirates ID must be provided.
UAE Regulatory & Data Privacy Adherence
This test is regulated under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed in an ISO 9001:2015 certified facility (Cert: INT/EGQ/2509DA/3139). Clinical testing safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory operates under DHA Facility License Number 1143 and follows international standards for genomic testing and data security.
Clinical & Logistical Metadata
| Test Name | RAG1 Gene Sequencing for SCID |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA (≥2 µg), or FTA Card – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM–11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) + CNV analysis, Sanger confirmation |
| ICD-10-CM Code | D81.1 |
| LOINC Code | 81263-8 |
| DHA Facility License & Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians