Test Price
2,800 AED✅ Home Collection Available
PSEN1 Gene Acne Inversa (Familial Type 3) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Next-Generation Sequencing (NGS) with clinical-grade variant interpretation.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM).
Clinical Guidance: Post-Test Genetic Counseling with Lina Osama Zaki Quteineh (DHA: 9294403) for result interpretation and family risk assessment.
Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This test uses Next-Generation Sequencing (NGS) to analyse the entire coding region of the PSEN1 gene for pathogenic variants linked to familial acne inversa (hidradenitis suppurativa) type 3. The analysis provides a definitive molecular diagnosis, informs personalised treatment strategies, and identifies at-risk family members.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | Targeted full-gene NGS with >99.9% analytical sensitivity | Single-exon Sanger; may miss deep intronic or promoter variants |
| Methodology | Illumina NovaSeq X Plus / HiSeq NGS with advanced bioinformatics | Capillary electrophoresis; manual interpretation |
| Turnaround Time | 3–4 Weeks (comprehensive report) | 5–6 Weeks |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I emphasize that the PSEN1 result must be interpreted alongside clinical phenotype and pedigree analysis. A positive finding confirms the diagnosis and enables tailored surveillance and cascade testing for family members. A negative result does not rule out other genetic or environmental contributors—dermatological follow-up remains essential.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License 9294403.
⚠️ Medication Advisory
Do not discontinue or modify any prescribed medication (e.g., biologics, antibiotics, retinoids) without consulting your treating physician. Genetic test results are not a substitute for ongoing clinical management.
🚑 Exclusion Criteria & Emergency Red Flags
- Patients under 18 years: genetic testing requires legally authorised guardian consent as per UAE regulations.
- Active systemic infection, sepsis, or acute exacerbation of hidradenitis suppurativa with fever – seek immediate medical care; genetic testing is not an emergency diagnostic tool.
- Severe anaemia or coagulopathy that contraindicates venipuncture; an FTA card finger-prick sample is the safe alternative.
- If you experience sudden severe pain, spreading redness, or pus collection, proceed to the nearest emergency department regardless of pending test results.
Patient FAQ & Clinical Guidance
1. What is the PSEN1 gene test for familial acne inversa?
Snippet: NGS-based PSEN1 analysis confirms familial hidradenitis suppurativa type 3, guiding targeted therapy and family counselling.
Clinically, this test detects disease-causing mutations in the PSEN1 gene, which encodes a component of the γ-secretase complex critical for Notch signalling. Pathogenic variants disrupt keratinocyte differentiation and immune function, leading to chronic follicular occlusion. Results assist dermatologists in confirming diagnosis, predicting severity, and advising blood relatives about their risk.
2. How is the sample collected and processed?
Snippet: Home phlebotomy service collects blood; PSEN1 NGS test detects acne inversa mutations in 3–4 weeks.
A trained phlebotomist visits your home, draws a small venous blood sample, and immediately transfers it into a DNA-stabilising tube under cold-chain conditions. Alternatively, a single drop of blood on an FTA card is accepted. DNA is extracted in our ISO-certified laboratory, enriched for the PSEN1 locus, and sequenced on high-throughput NGS platforms. Bioinformatics pipelines align reads, call variants, and annotate pathogenicity following ACMG/AMP guidelines.
3. Is this genetic test covered by health insurance in the UAE?
Snippet: WhatsApp verification confirms insurance coverage; UAE plans often reimburse PSEN1 testing for familial hidradenitis suppurativa.
We offer a direct billing verification service via WhatsApp (+971 54 548 8731). Simply send your insurance card, and our team will confirm coverage within minutes. Many UAE insurers consider PSEN1 testing medically necessary when there is a strong family history of hidradenitis suppurativa or clinical suspicion, making reimbursement straightforward under dermatology or genetic counselling benefits.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
This test is performed under the regulatory oversight of the Dubai Health Authority (DHA) and complies with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — ensuring the confidentiality and security of your genetic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — governing the safe use of digital health systems and electronic medical records.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — protecting patient consent and clinical safety standards.
All sample handling, sequencing, and result reporting are conducted in a DHA-licensed facility under strict quality control (ISO 9001:2015).
Clinical & Logistical Metadata
| Test Name | PSEN1 Gene Sequencing for Familial Acne Inversa (Type 3) – NGS |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) or FTA card finger-prick; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina NovaSeq X Plus; bioinformatics analysis per ACMG/AMP guidelines |
| ICD-10-CM Code | L73.2 (Hidradenitis suppurativa); Z82.2 (Family history of skin conditions) |
| LOINC Code | 91811-1 (PSEN1 gene sequencing) |
| DHA Facility License & Address | DHA License No. 1143 DNA Labs UAE Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians