Test Price
2,800 AEDโ Home Collection Available
PROP1 Gene Pituitary Hormone Deficiency Type 2 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Executive Summary
This advanced genetic test screens for mutations in the PROP1 gene responsible for combined pituitary hormone deficiency type 2, delivering a diagnostic sensitivity of 99.9% via ISO 15189-accredited next-generation sequencing. The service includes temperature-controlled cold-chain home collection, direct billing verification with major UAE insurers via WhatsApp, and a mandatory post-test telephonic genetic counseling session to guide clinical management.
- โAccuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189:2022 Accredited NGS Platform.
- โPremium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- โClinical Guidance: Mandatory pre- and post-test genetic counseling with a board-certified medical geneticist included in the test fee.
- โInsurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The PROP1 Gene NGS Test screens for mutations causing combined pituitary hormone deficiency type 2 (CPHD2), a congenital disorder affecting growth, thyroid, and adrenal function. This assay employs next-generation sequencing with Sanger confirmation to deliver precise variant detection across all coding exons of the PROP1 gene, empowering early diagnosis and tailored endocrine management.
| Feature | DNA Labs UAE PROP1 Test | Closest Alternative (Sanger Sequencing Only) |
|---|---|---|
| Methodology | NGS with Sanger validation & Deletion/Duplication Analysis | Single-gene Sanger sequencing |
| Coverage | Complete coding region + intron/exon boundaries | Limited to known hotspot regions |
| Turnaround Time | 3โ4 weeks | 4โ6 weeks |
| Clinical Reporting | ACMG Guidelines-compliant, with familial variant segregation | Binary mutation report only |
Physician Insight & Safety Protocols
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication & Clinical Advisory
Critical Warning: Do not discontinue prescribed medication (e.g., hydrocortisone, levothyroxine, growth hormone) without consulting your doctor. Abrupt withdrawal can trigger life-threatening adrenal crisis or severe hypothyroidism. This test is intended for diagnostic confirmation and should not be used to adjust medication dosages without specialist oversight.
Safety & Exclusion Criteria
- Exclusion Criteria: The test is not a replacement for newborn screening; it is indicated only when clinical or biochemical suspicion exists. Do not perform as a standalone tool for acute pituitary decompensation.
- Emergency Red Flags: If the patient develops severe hypotension, hypoglycemia, hyponatremia, or altered consciousness, seek immediate emergency care โ these signs may indicate an adrenal crisis requiring urgent medical intervention.
- Sample Integrity: Specimens must be collected in the provided DNA-stabilizing EDTA tubes. Improper storage, hemolysis, or insufficient volume may lead to test cancellation or redraw.
- Genetic Counseling: A pre-test consultation with a clinical geneticist is mandatory to document pedigree and obtain informed consent, as required by Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What does a positive PROP1 gene test result mean for my child's health?
A positive result confirms a homozygous or compound heterozygous mutation responsible for combined pituitary hormone deficiency. This finding guides lifelong multi-hormone replacement therapy and regular endocrine surveillance to ensure optimal growth and metabolic health.
2. How should I prepare my infant for the sample collection?
No special fasting, dietary, or medication changes are required. Our trained phlebotomist will collect a small blood volume using a pediatric-friendly venipuncture kit in the comfort of your home, following strict cold-chain protocols to maintain sample integrity.
3. Is this test covered by my UAE insurance plan?
We verify coverage with all major insurers within one hour. Simply share your policy details via WhatsApp; we obtain full pre-authorization before scheduling the home collection visit, ensuring no unexpected out-of-pocket costs.
4. How long does it take to receive the genetic report?
The standard turnaround time is 3 to 4 weeks from the date the sample reaches our laboratory. This accounts for the NGS sequencing run, bioinformatics analysis, Sanger confirmation, and comprehensive clinical reporting by our genetics team.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-restricted, and processed solely for diagnostic purposes with explicit patient consent under Federal Decree-Law No. 4 of 2016 on Medical Liability.
Our facility holds ISO 15189:2022 accreditation for medical laboratories and is fully licensed by the Dubai Health Authority (DHA License No. 1143). We adhere to the highest standards of data security, patient confidentiality, and clinical accuracy.
Clinical & Logistical Metadata
| Test Name | PROP1 Gene Pituitary Hormone Deficiency Type 2 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) or extracted gDNA |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | E23.0, Z15.89, Z13.79 |
| LOINC Code | 103431-8 |
| DHA Facility License & Lab Address | DHA License No: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians