Test Price
2,800 AED✅ Home Collection Available
PROKR2 Gene Hypogonadotropic Hypogonadism Type 3 (with or without Anosmia) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Complementary hospital-grade home collection by DHA-licensed phlebotomists using ISO-certified cold-chain transport.
- Clinical Guidance: Post-test telephonic consultation with a clinical geneticist to interpret your PROKR2 variant report.
- Insurance: Direct billing verification & reconciliation via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing test analyzes the entire coding region of the PROKR2 gene to detect pathogenic variants causing hypogonadotropic hypogonadism type 3. The condition may include anosmia (Kallmann syndrome) or normosmic isolated hypogonadotropic hypogonadism. It is a definitive genetic tool for reproductive endocrinology and family planning in the UAE.
| Feature | Our Test (PROKR2 NGS) | Closest Alternative |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) of full PROKR2 gene | Single-gene Sanger sequencing (limited coverage) |
| Diagnostic Yield | >95% detection of known pathogenic variants | ~80%, may miss deep intronic or copy-number variants |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Clinical Report | Includes ACMG classification, pedigree analysis, and genetic counselling note | Basic variant list without clinical interpretation |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403: "The PROKR2 NGS test provides a definitive molecular diagnosis for idiopathic hypogonadotropic hypogonadism. Identifying a pathogenic variant can inform family screening and reproductive decisions. However, a negative result does not exclude other genetic or structural causes; comprehensive clinical evaluation remains paramount."
Medication Advisory
Do not alter or discontinue any prescribed hormonal treatments or gonadotropin therapy without consulting your endocrinologist. Abrupt cessation may cause significant hormonal imbalance and metabolic disturbances.
Exclusion Criteria & Emergency Red Flags
- Inability to provide informed consent (mandatory genetic counselling pre-test).
- Pregnancy (postpone testing until after delivery unless urgent for family planning).
- Acute febrile illness or recent blood transfusion (may interfere with DNA quality).
- Seek immediate medical attention if you experience sudden severe headache, visual field defects, or acute adrenal crisis symptoms — these are not related to the genetic test but require urgent endocrine evaluation.
Patient FAQ & Clinical Guidance
1. What does the PROKR2 genetic test detect?
This NGS test identifies single nucleotide variants and small deletions/duplications in the PROKR2 gene that cause type 3 hypogonadotropic hypogonadism, which may present with absent puberty, infertility, and absent or reduced sense of smell (anosmia/hyposmia).
2. How is the sample collected, and is home collection available?
A simple blood draw or a dried blood spot on an FTA card can be used; we dispatch a DHA-licensed phlebotomist to your home, office, or hotel across all seven emirates from 8 AM to 11 PM — at no extra cost.
3. What is the cost, and will my insurance cover it?
The cost is 2800 AED, and we offer direct insurance billing; our team will verify your coverage via WhatsApp before the collection, ensuring full transparency and minimal out-of-pocket expense.
UAE Regulatory & Data Privacy Adherence
All genetic testing at DNA Labs UAE is conducted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic data is encrypted, stored securely, and accessed only by authorized personnel. Our DHA Facility License No. 1143 ensures adherence to Dubai Healthcare City Authority standards.
Clinical & Logistical Metadata
| Test Name | PROKR2 Gene Hypogonadotropic Hypogonadism Type 3 (with or without Anosmia) – NGS |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood or Dried Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Sequencing |
| ICD-10-CM Code | E23.0 (Hypogonadotropic hypogonadism) |
| LOINC Code | 94716-0 (PROKR2 gene mutation analysis) |
| DHA Facility License & Address | License: 1143 | Laboratory: DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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