Test Price
2,800 AED✅ Home Collection Available
POLR3B Gene Leukodystrophy Hypomyelinating Type 8 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين POLR3B لتشخيص حثل المادة البيضاء ناقص التغميد النوع الثامن في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي: فحص جيني متطور بتقنية التسلسل من الجيل التالي (NGS) يُؤكِّد تشخيص حثل المادة البيضاء ناقص التغميد من النوع الثامن بدقة تشخيصية تبلغ 99.9% عبر مختبر معتمد أيزو 9001، مع خدمة سحب منزلي فاخرة واستشارة طبية بعد الفحص.
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑Accredited Processing.
- ✓ Premium Logistics: Paid Hospital‑Grade Home Collection via ISO‑Certified Cold‑Chain Home Collection & VIP Mobile Phlebotomy.
- ✓ Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Overview
This next‑generation sequencing (NGS) test analyzes the POLR3B gene to confirm hypomyelinating leukodystrophy type 8, a rare inherited neurological disorder. هذا الفحص الجيني يؤكد تشخيص المرض بدقة عبر تحليل الحمض النووي باستخدام تقنية NGS.
| Feature | Our Test – POLR3B NGS | Closest Alternative – Single‑Gene Sanger |
|---|---|---|
| Methodology | NGS (Next‑Generation Sequencing) | Sanger Sequencing (limited to known variants) |
| Diagnostic Sensitivity | 99.9% (full gene coverage) | ~90% (only targeted regions) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| ISO 9001:2015 Lab | Yes (Cert: INT/EGQ/2509DA/3139) | Varies |
Physician Insight & Safety Protocol
“A positive POLR3B result provides a definitive molecular diagnosis, allowing families to end a long diagnostic odyssey. However, every genetic finding must be correlated with your clinical picture by a neurologist. I urge you not to face this report alone — our team is here to interpret it with compassion and clarity.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
⛔ Medication Warning:
Do not discontinue prescribed medication without consulting your doctor. Genetic test results should guide, not replace, your neurologist’s management plan.
⚠️ Patient Safety & Exclusion Criteria
- Exclusion Criteria: Inability to provide informed consent (for minors, legal guardian consent is mandatory per UAE CDS Law 2026).
- Exclusion: Active febrile illness may delay home collection; reschedule when afebrile.
- ER Red Flags: If the patient experiences sudden vision loss, seizures, or acute motor regression, seek emergency neurological care immediately — do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the purpose of the POLR3B gene test?
This test definitively diagnoses hypomyelinating leukodystrophy type 8 by detecting disease‑causing variants in the POLR3B gene using high‑coverage NGS. It is the gold‑standard molecular confirmation for individuals with suggestive MRI findings or family history of leukodystrophy.
يُستخدم هذا الفحص لتأكيد تشخيص حثل المادة البيضاء ناقص التغميد النوع الثامن عبر الكشف عن الطفرات المسببة للمرض.
2. How is the sample collected and what are the pre‑test requirements?
We accept whole blood, extracted DNA, or one drop of blood on an FTA card; all collections are performed under strict cold‑chain by licensed phlebotomists. Pre‑ genetic counselling is mandatory to draw a pedigree of affected family members and obtain informed consent, in full compliance with UAE PDPL.
يتم جمع العينة بواسطة فني سحب مرخص مع ضرورة جلسة استشارة وراثية قبل الفحص لرسم شجرة العائلة.
3. What do the results mean and how will I receive them?
A positive report confirms the clinical diagnosis; negative means no pathogenic variant was detected but does not exclude other leukodystrophies. Results are securely delivered via encrypted email and a telephonic consultation with a DHA‑licensed genetic counselor is provided to explain the findings in plain language.
النتائج الإيجابية تؤكد التشخيص، والسلبية لا تستبعد الأمراض الأخرى؛ يتم تسليمها بمشورة هاتفية مع مستشار وراثي.
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