Test Price
2,800 AED✅ Home Collection Available
POLG Gene Progressive External Ophthalmoplegia with Mitochondrial Deletions Type 1, Autosomal Dominant (Genetic Test) in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين POLG لاعتلال العين الخارجي التدريجي مع الحذف الميتوكوندري من النوع الأول الوراثي السائد (اختبار الحمض النووي بتقنية التسلسل الجيني الشامل) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي 2026
Executive Summary & UAE Precision Guarantee
- 99.9% Diagnostic Sensitivity – ISO 15189/ISO 9001:2015 accredited NGS laboratory processing with full POLG gene coverage (including deep intronic and copy number variations).
- Premium Hospital‑Grade Home Collection – Certified cold‑chain logistics (ISO 9001:2015) and VIP mobile phlebotomy service (DHA‑licensed) across all emirates.
- Telephonic Post‑Test Clinical Guidance – Expert interpretation of results by a neurologist and genetic counsellor, correlated with your clinical history.
- Direct Insurance Billing Verification – WhatsApp +971 54 548 8731 for instant pre‑approval and coverage check (Federal Decree‑Law No. 41/2024 compliant).
ملخص تنفيذي: دقة تشخيصية 99.9% عبر معالجة معتمدة بمعيار ISO. خدمة جمع عينات منزلية فاخرة بمستوى المستشفيات بوساطة سلسلة تبريد معتمدة. استشارة سريرية هاتفية بعد النتائج. التحقق المباشر من تغطية التأمين عبر واتساب: 00971545488731.
Overview
The POLG gene test uses next‑generation sequencing (NGS) to detect autosomal dominant pathogenic variants causing progressive external ophthalmoplegia with mitochondrial deletions type 1 (PEOA1) – a multi‑system mitochondrial disorder. This comprehensive assay provides a definitive molecular diagnosis, guiding targeted surveillance, family counselling, and reproductive options.
يقوم اختبار جين POLG باستخدام التسلسل الجيني الشامل (NGS) لكشف الطفرات الموروثة السائدة المسببة لاعتلال العين الخارجي التدريجي مع الحذف الميتوكوندري.
| Feature | Our Test (NGS – POLG Full Gene) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Analytical Sensitivity | 99.9% (SNVs, indels, CNVs) | ~95% (misses large deletions) |
| Turnaround Time | 3 – 4 weeks | 4 – 6 weeks |
| Molecular Coverage | All 23 exons + intron boundaries + mtDNA deletions | Selected exons only |
Physician Insight & Safety Protocol
"As a clinical neurologist, I remind every patient that this genetic test provides essential biological information, but it must always be integrated with your neurological examination, muscle biopsy findings (if any), and detailed family history. A positive POLG variant is highly informative, yet clinical correlation remains the cornerstone of management and prognosis."
— Dr. PRABHAKAR REDDY, Consultant Neurologist, DHA License: 61713011
Medication Warning:
Do not discontinue or adjust any prescribed medication (especially antiepileptics, cardiac drugs, or mitochondrial supplements) without consulting your treating physician.
Safety Exclusion Criteria & Red Flags
- Exclusion: Acute febrile illness, recent blood transfusion (<4 weeks), active infection interfering with DNA integrity.
- Exclusion: DNA samples with degradation or inadequate quantity (requires recollection).
- Emergency Red Flags: Sudden severe ptosis, new‑onset diplopia, progressive dysphagia, cardiac conduction abnormalities (syncope, palpitations), or rapid muscle weakness – seek immediate emergency care.
Patient FAQ & Clinical Guidance
What does the POLG gene test detect?
This test detects pathogenic DNA variants in the POLG gene responsible for autosomal dominant progressive external ophthalmoplegia with mitochondrial deletions type 1. يكشف هذا الاختبار عن الطفرات الممرضة في جين POLG المسببة لاعتلال العين الخارجي التدريجي مع الحذف الميتوكوندري من النوع الأول الوراثي السائد. It screens all coding regions and adjacent splice sites, as well as copy number variations, providing a definitive molecular diagnosis.
How is the performed?
A simple blood draw, one drop of blood on a DNA FTA card, or extracted DNA sample is collected in your home by a DHA‑certified phlebotomist. يتم جمع العينة عبر سحب دم بسيط أو قطرة دم على بطاقة FTA في منزلك بواسطة فني معتمد من هيئة الصحة بدبي. The sample is transported under cold‑chain ISO conditions to our genetics laboratory, and results are ready in 3 to 4 weeks.
What are the implications of a positive result?
A positive result confirms the clinical diagnosis, enables cascade testing in at‑risk relatives, and guides tailored mitochondrial surveillance protocols. النتيجة الإيجابية تؤكد التشخيص السريري وتسمح بفحص الأقارب المعرضين للخطر وتوجيه بروتوكولات المراقبة الميتوكوندرية المخصصة. Genetic counselling is mandatory before and after testing to discuss inheritance probability (50% for offspring) and potential medical interventions.
UAE Regulatory Compliance
This service adheres to Federal Decree‑Law No. 41 of 2024 (Art. 87) on healthcare advertising, CDS Law 2026 (minors’ genetic testing requires legal guardian consent), and the UAE Personal Data Protection Law (PDPL). Your genetic data is processed exclusively within UAE‑based secure servers with end‑to‑end encryption.
Accreditation: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139); DHA Facility License: 9834453.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians