Test Price
2,800 AED✅ Home Collection Available
PIGW Gene Hyperphosphatasia with Mental Retardation Syndrome Type 5 (HPMRS5) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Post-test telephonic result interpretation by DHA-licensed genetic counsellors.
- Pricing: 2,800 AED inclusive of end-to-end service.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The PIGW gene test utilizes Next-Generation Sequencing (NGS) to analyze the full coding region of the PIGW gene, detecting pathogenic variants associated with Hyperphosphatasia with Mental Retardation Syndrome Type 5 (HPMRS5, Mabry syndrome). This advanced molecular diagnostic approach provides a definitive etiological diagnosis, enabling tailored clinical management and accurate family counselling.
| Feature | Our Test – PIGW NGS | Standard Alternative – Sanger Sequencing |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS), full gene coverage | Sanger sequencing of coding regions only |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Detection Rate | >99% for point mutations, small indels, and copy number variants | ~95% for point mutations; limited CNV detection |
| Price (AED) | 2,800 | Variable (3,500 – 4,000) |
Physician Insight & Safety Protocols
"As a Consultant in Medical Genetics, I, Lina Osama Zaki Quteineh (DHA Registration ID: 9294403), emphasize that the interpretation of PIGW genetic testing must be correlated with comprehensive clinical findings and a detailed family pedigree. Early molecular confirmation of HPMRS5 profoundly impacts seizure management, developmental intervention strategies, and informed reproductive counselling for affected families."
Clinical Advisory: Medication Adherence
Do not discontinue or alter prescribed medications, including anticonvulsants, without direct consultation with your treating physician. This diagnostic test is not a therapeutic intervention.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide a suitable biological specimen; non-consenting individuals (parental or guardian consent is mandatory for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Red Flags: This test is not for acute emergency diagnosis. If the patient experiences uncontrolled seizures, sudden loss of consciousness, severe respiratory distress, or extreme lethargy, seek immediate care at the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the PIGW gene test for?
Answer: This NGS test is designed to identify pathogenic mutations in the PIGW gene, which causes Hyperphosphatasia with Mental Retardation Syndrome Type 5 (HPMRS5). It is used to confirm a clinical diagnosis in patients presenting with elevated serum alkaline phosphatase, intellectual disability, seizures, and distinctive facial features. The results guide prognosis, targeted therapies, and family planning.
2. How is the test performed, and what sample is needed?
Answer: The test requires a standard peripheral whole blood sample. Our VIP Mobile Phlebotomy service (available daily from 8 AM to 11 PM) ensures painless sample collection at your home. The specimen is transported via a temperature-controlled cold chain to our ISO-accredited laboratory. NGS sequencing and analysis are completed within 3–4 weeks, followed by a comprehensive report and telephonic guidance.
3. Is this genetic test covered by insurance in the UAE?
Answer: Many UAE health insurance plans cover clinically indicated genetic tests when ordered by a specialist. Contact our billing team via WhatsApp at +971 54 548 8731 for an instant verification of your policy benefits and to check direct billing eligibility.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient genomic data is encrypted, securely stored, and processed exclusively for clinical diagnostic purposes with explicit patient consent, ensuring the highest standards of confidentiality and ethical compliance.
Clinical Governance: Our laboratory operations are conducted under the regulatory oversight of the Dubai Health Authority (DHA) and the Ministry of Health and Prevention (MOHAP), strictly following Federal Decree-Law No. 4 of 2016 on Medical Liability. We hold ISO 9001:2015 accreditation (Cert: INT/EGQ/2509DA/3139) for our comprehensive quality management system.
Clinical & Logistical Metadata
| Test Name | PIGW Gene Hyperphosphatasia with Mental Retardation Syndrome Type 5 (HPMRS5) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood, Extracted DNA, or FTA Card Sample |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | E83.39 (Hyperphosphatasia), Q87.89 (Other specified congenital malformation syndromes) |
| LOINC Code | 81263-4 (PIGW gene mutation analysis in Blood or Tissue by NGS) |
| DHA Facility License & Laboratory Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | License No: 1143 |
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