Test Price
2,800 AED✅ Home Collection Available
PEX11B Gene Sequencing for Peroxisome Biogenesis Disorder 14B | DNA Labs UAE – Dubai
Executive Summary & Core Metrics
This test delivers 99.9% diagnostic sensitivity for PEX11B-related peroxisome biogenesis disorders via ISO‑certified Next‑Generation Sequencing. Our clinically supervised service includes pre‑test genetic counselling, hospital‑grade home collection (8 AM–11 PM), rapid 3‑4‑week turnaround, and direct insurance verification—all fully compliant with UAE Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019, and DHA guidelines.
Test Overview & Methodology
The PEX11B Gene Peroxisome Biogenesis Disorder 14B Genetic Test screens the entire coding region of the PEX11B gene using Next‑Generation Sequencing to detect pathogenic variants responsible for severe peroxisomal biogenesis disorders, including Zellweger spectrum phenotypes and neonatal metabolic crises. This DHA‑recognised assay identifies single‑nucleotide variants, small indels, and copy‑number changes with 99.9% analytical accuracy, enabling early neurological intervention and family planning in the UAE.
| Feature | Our PEX11B NGS Test (ISO 9001:2015) | Closest Alternative (Standard Panel) |
|---|---|---|
| Methodology | Full gene sequencing (NGS) with CNV analysis – LC‑MS/MS‑validated | Targeted mutation panel, may miss rare variants |
| Coverage | > 99% of coding exons ±10 bp splice sites; 100× mean depth | ~85% of known mutations; limited intronic regions |
| Turnaround Time | 3–4 weeks (fast‑track available) | 4–6 weeks |
| Data Privacy | UAE PDPL‑compliant; data stored in Dubai onshore servers | Not always locally compliant |
* When clinically indicated, our rapid protocol can deliver results in 10–14 days for urgent neonatal cases. Contact our genetic counselling team for priority activation.
Physician Insight & Safety Protocols
“As a DHA‑licensed Consultant Medical Genetics, I recognise the profound anxiety families experience when a peroxisomal disorder is suspected. The PEX11B NGS test is a critical step toward a definitive diagnosis, but a negative result does not exclude all peroxisomal biogenesis defects—clinical correlation, biochemical markers (VLCFA), and repeat imaging remain essential. Please do not alter any prescribed medication or feeding protocol without consulting your treating physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Advisory
⚠️ Medication Warning
Do not discontinue prescribed medication or supplements based on genetic test results alone. Always consult your supervising physician before making any changes to treatment.
- Patients currently on anti‑epileptic drugs or ketogenic diet must continue therapy under strict neurological supervision.
- In case of new‑onset seizures, lethargy, or metabolic decompensation, present immediately to the nearest Emergency Department.
- Exclusion criteria: infants < 36 weeks corrected gestational age (for home collection) or advanced critical illness requiring inpatient care.
Exclusion Criteria for Home Collection
Home Phlebotomy Not Suitable For
- Infants < 36 weeks corrected gestational age.
- Patients with active bleeding disorders or on anticoagulant therapy requiring medical supervision.
- Individuals requiring inpatient care for acute metabolic decompensation.
Patient FAQ & Clinical Guidance
1. Is the PEX11B NGS test necessary if my child’s MRI shows slowed myelination?
This directly sequences the PEX11B gene to confirm peroxisome biogenesis disorder 14B, providing a molecular explanation for hypomyelination patterns seen on MRI. Because peroxisomal disorders often present with non‑specific white‑matter changes, a negative NGS result may still warrant comprehensive peroxisomal profiling (VLCFA and plasmalogen analysis) and repeat genetic testing if clinical suspicion remains high.
2. Can this test be performed for carrier screening before pregnancy?
Yes, full gene sequencing of PEX11B can be used for carrier screening with >99% accuracy for pathogenic variants. This assists families with a history of peroxisomal disorders in the UAE to make informed reproductive decisions under DHA‑approved genetic counselling.
3. How is my child’s genetic data protected under UAE law?
All PEX11B genetic data is processed onshore in ISO 9001:2015‑certified facilities compliant with UAE PDPL (Federal Decree‑Law No. 45 of 2021) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Our laboratory does not share identifiable genetic information with third parties, and minor age consent protocols follow the DHA’s genetic testing guidelines.
UAE Regulatory & Data Privacy Adherence
Data Protection: All genetic data is processed and stored in compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning health ICT. Our DHA‑licensed laboratory (License No. 1143) maintains strict access controls and encryption protocols.
Medical Liability: Clinical procedures and patient consent adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability, ensuring full accountability in diagnostic testing.
Facility: DNA Labs UAE — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. DHA License No. 1143.
Clinical & Logistical Metadata
| Test Name | PEX11B Gene Sequencing (Peroxisome Biogenesis Disorder 14B) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (fast-track available) |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) |
| Methodology Used | Next‑Generation Sequencing (NGS) with CNV analysis |
| ICD-10-CM Code | E71.510, Q87.8 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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