Test Price
2,800 AED✅ Home Collection Available
PCSK9 Gene Hypercholesterolemia Autosomal Dominant Type 3 Genetic Test in UAE
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity ISO 9001:2015 Certified • DHA‑Licensed Facility #1143
- VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection: 8 AM – 11 PM
- Telephonic Post‑Test Clinical Guidance with a Consultant Medical Geneticist
- Direct Insurance Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
The PCSK9 Genetic Test precisely identifies pathogenic and likely pathogenic variants in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia type 3 (Familial Hypercholesterolemia 3). This test provides actionable insights for risk stratification, personalised lipid‑lowering therapy, and family cascade screening, fully aligned with current DHA cardiogenetic guidelines.
| Feature | Our NGS Test (This Service) | Closest Alternative |
|---|---|---|
| Methodology | Next Generation Sequencing (full gene coverage, CNV detection) | Targeted Genotyping (limited variants) |
| Diagnostic Precision | 99.9% Analytical Sensitivity | ~95% for selected SNPs only |
| Turnaround Time | 3–4 Weeks (ISO‑certified lab) | 2–3 Weeks (may lack comprehensive interpretation) |
| Regulatory & Accreditation | DHA‑Licensed, ISO 9001:2015, UAE PDPL Compliant | Often not DHA‑specific; variable privacy standards |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403: “The PCSK9 NGS assay detects the full spectrum of causative variants, enabling precise familial risk stratification and targeted therapy decisions. Results must be interpreted in conjunction with fasting lipid profiles, pedigree analysis, and clinical examination. This genetic information complements, not replaces, long-term cardiovascular risk management.”
Pre‑Test Requirements & Genetic Counselling
A detailed clinical history and a genetic counselling session to draw a pedigree chart of family members affected with hypercholesterolemia autosomal dominant type 3 are mandatory before sample collection. This ensures accurate variant interpretation and cascade testing readiness.
Accepted Samples: Whole Blood (EDTA), Extracted DNA, or One Drop of Blood on FTA Card. VIP mobile phlebotomy and cold‑chain home collection are available daily from 8 AM to 11 PM for whole blood samples.
Medication Warning & Safety Exclusion Criteria
Do not discontinue prescribed lipid‑lowering medication or alter therapy based solely on this genetic result without consulting your physician.
Safety Exclusion Criteria & ER Red Flags
- Individuals unable to provide informed consent or lacking a clinically indicated hypercholesterolemia phenotype.
- Current acute coronary syndrome, unstable angina, or emergency chest pain. If you experience sudden chest pressure, shortness of breath, or signs of stroke, proceed to the nearest emergency department immediately – this test is not for urgent diagnosis.
Patient FAQ & Clinical Guidance
1. What is PCSK9 gene testing and who needs it in the UAE?
PCSK9 Genetic Testing identifies pathogenic variants causing autosomal dominant hypercholesterolemia type 3 to assess cardiovascular risk and guide treatment. It is recommended for individuals with LDL‑C >190 mg/dL, family history of early heart disease, or suspected familial hypercholesterolemia. In the UAE, this test supports DHA‑endorsed preventive cardiology programmes and family screening.
2. How accurate is this and what does the 3‑4 week turnaround time mean?
Our NGS assay achieves 99.9% analytical sensitivity with comprehensive coverage of all coding exons and splice junctions. The 3‑4 week turnaround includes library preparation, sequencing, bioinformatics analysis, and expert clinical interpretation. Every variant is classified according to current ACMG/AMP guidelines, ensuring a clinically actionable report.
3. Are home collection services available and is data privacy protected under UAE law?
Yes, we provide hospital‑grade VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection from 8 AM to 11 PM with full compliance with UAE PDPL (Federal Decree-Law No. 45 of 2021). Our phlebotomists follow DHA infection control protocols, and all genetic data is encrypted and processed within a UAE‑based facility licensed under DHA license #1143. Minors’ samples are handled strictly per Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields and Federal Decree-Law No. 4 of 2016 on Medical Liability for clinical safety.
UAE Regulatory & Data Privacy Adherence
Trust & Compliance
DNA Labs UAE fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all personal data handling, storage, and processing. Our clinical operations adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for secure health data exchange. Patient safety and informed consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory is DHA‑licensed (Facility #1143) and ISO 9001:2015 certified, ensuring the highest standards of quality and confidentiality.
Clinical & Logistical Metadata
| Test Name | PCSK9 Gene Hypercholesterolemia Autosomal Dominant Type 3 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card Blood Spot – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available |
| Methodology Used | Next Generation Sequencing (NGS) – Full gene coverage, CNV detection |
| ICD-10-CM Code | E78.01 (Familial hypercholesterolemia) |
| LOINC Code | 55233-1 (PCSK9 gene mutation analysis) |
| DHA Facility License & Laboratory Address | License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians