Test Price
2,800 AED✅ Home Collection Available
OPA3 Gene (3-Methylglutaconic Aciduria Type III) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Your Guarantee
- Diagnostic Precision: 99.9% diagnostic sensitivity via ISO 9001:2015‑accredited NGS laboratory processing.
- Premium At‑Home Phlebotomy: Hospital‑grade home collection with ISO‑certified cold‑chain transport and VIP mobile phlebotomy service.
- Post‑Test Clinical Guidance: Dedicated telephonic consultation with a clinical geneticist to interpret your genetic results.
- Insurance Support: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The OPA3 Gene NGS test sequences the entire coding region of the OPA3 gene to detect pathogenic variants responsible for 3‑Methylglutaconic Aciduria Type III (Costeff syndrome), a rare autosomal recessive metabolic disorder. This gold‑standard genomic analysis replaces outdated biochemical screens, offering definitive confirmation for at‑risk individuals, carrier screening, and research‑grade precision.
| Feature | Our OPA3 NGS Test | Closest Alternative / Biochemical Screen |
|---|---|---|
| Target | Full OPA3 gene (all exons, splice sites) – comprehensive mutation detection | Urinary organic acids only; cannot differentiate OPA3 from other 3‑MGA types |
| Method | NGS (Next‑Generation Sequencing) with >100x coverage and confirmatory Sanger | GC‑MS or tandem MS; high false‑positive rate |
| Turnaround | 3 to 4 Weeks | 1–2 weeks but requires invasive second‑tier testing |
| Specimen | Whole blood, extracted DNA, or a single drop on FTA card | Fresh urine, strict collection conditions |
| Clinical Utility | Definitive diagnosis, carrier identification, family planning, targeted therapy | Screening only; often requires molecular confirmation |
Physician Insight & Safety Protocols
From the Desk of Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID 9294403): Genetic testing for OPA3 provides life‑changing clarity for families affected by unexplained metabolic crises. Every result must be correlated with the patient’s full clinical history, including early‑onset optic atrophy, movement disorders, and biochemical markers. I urge you to view this report not as a solitary answer, but as the starting point for a multidisciplinary care plan that safeguards your child’s future.
Advisory & Safety Warning
⚠️ Do not discontinue any prescribed medication or metabolic diet without explicit instruction from your managing physician.
This genetic test is diagnostic and cannot replace acute medical assessment. If the patient exhibits sudden vomiting, extreme lethargy, hypoglycemia, or altered consciousness, seek emergency care immediately.
Emergency Red Flags Post‑Test
- New‑onset metabolic acidosis, persistent vomiting, or seizures.
- Sudden visual loss or strabismus in a previously asymptomatic individual.
- Any sign of acute encephalopathy – proceed to nearest emergency department immediately.
Exclusion Criteria for Specimen Collection
- Active febrile illness or systemic infection at time of blood draw.
- Known coagulopathy or severe thrombocytopenia without physician clearance.
- Inability to provide informed consent (patients under 18 require legally authorized guardian’s consent per Federal Decree-Law No. 4 of 2016 on Medical Liability).
Patient FAQ & Clinical Guidance
1. What conditions does the OPA3 gene test diagnose, and why should you choose NGS over older methods?
Answer: This test definitively diagnoses 3‑Methylglutaconic Aciduria Type III (Costeff syndrome) by identifying pathogenic variants in the entire OPA3 gene. NGS offers >99% diagnostic sensitivity and detects novel mutations missed by targeted panels or biochemical assays, enabling precise family counselling and risk prediction.
2. How is the sample collected, and what is the exact process from booking to result delivery in the UAE?
Answer: A certified phlebotomist visits your home between 8 AM and 11 PM for a painless venous blood draw, or you can submit pre‑extracted DNA or an FTA card. Our cold‑chain logistics preserve sample integrity until it reaches our ISO‑accredited lab; you receive a secure, encrypted report within 3 to 4 weeks with optional post‑test tele‑consultation.
3. Can I trust the privacy of my genetic data, and is the test compliant with UAE health data laws?
Answer: Absolutely – all genetic data is processed under strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Our ISO 9001:2015 certification guarantees confidentiality. Your sample is de‑identified upon arrival, results are shared only through encrypted channels, and we never store or share data without explicit written consent.
UAE Regulatory & Data Privacy Adherence
Authority & Credentials
ISO 9001:2015 Certified Facility (Cert: INT/EGQ/2509DA/3139) | DHA License: 1143 | All testing adheres to DHA/MOHAP NGS standards and Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Corporate Lab: DNA Labs UAE
Clinical & Logistical Metadata
| Test Name | OPA3 Gene (3-Methylglutaconic Aciduria Type III) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole blood, extracted DNA, or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) with confirmatory Sanger sequencing |
| ICD-10-CM Code | E71.11 |
| LOINC Code | 94222-1 |
| DHA Facility License & Laboratory Address | DHA License: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab: DNA Labs UAE |
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