Test Price
2,800 AED✅ Home Collection Available
OCLN Gene (Band‑like Calcification with Simplified Gyration and Polymicrogyria) Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO‑accredited next‑generation sequencing with orthogonal Sanger confirmation.
- Premium Logistics: VIP mobile phlebotomy with temperature‑controlled cold‑chain home collection available daily from 8 AM to 11 PM across all UAE emirates.
- Clinical Guidance: Complimentary telephonic post‑test counselling with a consultant medical geneticist to interpret results and outline a management plan.
- Insurance & Billing: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next‑generation sequencing (NGS) test analyses the entire coding region of the OCLN gene to detect pathogenic variants responsible for band‑like calcification with simplified gyration and polymicrogyria (BLC‑PMG), a severe autosomal recessive neurodevelopmental disorder. Early molecular diagnosis in neonates and children presenting with dysmorphic features, profound developmental delay, and characteristic brain calcification enables targeted clinical management and informed family planning. The test employs Illumina® NGS with deep read depth exceeding 200× and orthogonal Sanger confirmation of all reported variants, ensuring comprehensive coverage including copy‑number variant detection.
Pre‑Test Genetic Counselling Requirement
A mandatory genetic counselling session is included in the test price. During this session, a detailed three‑generation pedigree is documented, clinical history is reviewed, and informed consent is obtained. No drug or supplement cessation is required for this DNA test; continue all prescribed medications unless otherwise instructed by your attending physician.
| Feature | Our OCLN NGS Test (ISO 9001:2015) | Closest Alternative (Conventional Sanger / Panel) |
|---|---|---|
| Precision | 100% coding‑region coverage with deep read depth (>200×) and copy‑number variant detection | Limited to a few hotspot exons; misses large rearrangements |
| Methodology | Illumina® NGS + orthogonal Sanger confirmation of all reported variants | PCR‑based fragment analysis or single‑gene Sanger without CNV resolution |
| Turnaround | 3–4 weeks with expedited telephone result counselling | 6–8 weeks |
Physician Insight & Safety Protocols
“As a DHA‑licensed Consultant Medical Geneticist, I emphasise that a positive OCLN variant must be correlated with the full clinical and radiological picture by a multidisciplinary team. Molecular diagnosis provides clarity but does not replace compassionate clinical judgement; genetic counselling remains the cornerstone of family‑centred care. Parents should understand that a confirmed diagnosis guides surveillance and management, not limitation of their child’s potential.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Continuation
Do not discontinue or alter any prescribed medication without prior consultation with your attending physician. This genetic test does not require any drug or supplement cessation.
Exclusion Criteria & Emergency Red Flags
- Venipuncture is contraindicated in patients with severe uncorrected coagulopathy unless cleared by a haematologist.
- If the child experiences acute neurological deterioration (e.g., prolonged seizure, apnoea, loss of consciousness), proceed immediately to the nearest Emergency Department — do not delay for genetic testing.
- Genetic testing cannot be performed without proper pre‑test counselling and written informed consent as mandated under Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. How is the OCLN gene test performed and which sample types are accepted?
A venous blood sample (3–5 mL in EDTA), extracted DNA, or a single drop of blood on a standard FTA card is accepted. Our VIP mobile phlebotomy team collects the sample at your home, workplace, or hospital in all UAE emirates between 8 AM and 11 PM under strict temperature‑controlled cold‑chain conditions.
2. What does a positive OCLN mutation result indicate for my child?
A positive result confirms the molecular diagnosis of band‑like calcification with simplified gyration and polymicrogyria. This guides surveillance for associated complications such as epilepsy, endocrine dysfunction, and hearing loss, and enables accurate recurrence risk counselling for parents and siblings. The result does not change your child’s fundamental potential — every supportive intervention should be pursued.
3. Is genetic counselling included in the test price?
Yes, the test price includes two genetic counselling sessions — one before sample collection to document family history and obtain informed consent, and one after results are available to help you understand the findings and plan next steps with the consultant medical geneticist.
4. How long does it take to receive the test results?
The laboratory turnaround time is 3–4 weeks from sample receipt. Results are reviewed and signed off by the consultant medical geneticist, and a telephonic counselling session is scheduled promptly to explain the report and its clinical implications.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework
All genetic data is processed in strict accordance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. The laboratory is ISO 9001:2015 accredited (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143. Your genetic information is encrypted, access‑controlled, and never shared with third parties without explicit written consent. Clinical safety and patient consent protocols adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | OCLN Gene (Band‑like Calcification with Simplified Gyration and Polymicrogyria) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next‑Generation Sequencing (NGS) with Orthogonal Sanger Confirmation |
| ICD-10-CM Code | Q04.8 |
| LOINC Code | 94473-2 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians