Test Price
2,800 AED✅ Home Collection Available
NT5C2 Gene SPG45 Genetic Test in UAE – NGS Full Gene Sequencing
Executive Summary & Core Metrics
This next‑generation sequencing (NGS) test analyses the entire coding region of the NT5C2 gene to identify pathogenic variants responsible for Hereditary Spastic Paraplegia type 45 (SPG45). It provides a definitive diagnosis, carrier testing, and family planning insights with a diagnostic sensitivity >99.9%.
- ✓ 99.9% Diagnostic Sensitivity via ISO 9001:2015 certified processing (Cert: INT/EGQ/2509DA/3139).
- ✓ Premium Logistics: Paid hospital‑grade home collection via ISO certified cold‑chain and VIP mobile phlebotomy (8 AM – 11 PM).
- ✓ Clinical Guidance: Telephonic post‑test clinical guidance by DHA‑licensed specialists for result interpretation.
- ✓ Insurance Support: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The NT5C2 Gene SPG45 NGS Test sequences the entire coding region of the NT5C2 gene using next‑generation sequencing to identify single‑nucleotide variants, small insertions/deletions, and copy number changes. This comprehensive analysis supports definitive diagnosis of hereditary spastic paraplegia type 45 (SPG45), carrier testing, and informed family planning. Turnaround time is 3–4 weeks.
Our Test vs. Standard Alternative
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Methodology | NGS (Full Gene Sequencing) | Sanger (single‑exon) |
| Diagnostic Sensitivity | >99.9% | ~95% |
| Turnaround Time | 3–4 Weeks | 5–6 Weeks |
| Price (AED) | 2,800 | 3,200+ |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasize that this NGS test provides high diagnostic accuracy for SPG45. However, genetic results must always be interpreted in conjunction with a full clinical examination and family history. A negative result does not rule out all hereditary spastic paraplegias or related movement disorders. Our team is here to guide you through the next steps.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Do Not Alter Prescribed Therapies
⚠ Important: Do not discontinue or modify any prescribed medication or treatment plan without consulting your physician. Genetic test results inform long‑term management, not acute changes.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Inability to provide informed consent; severe coagulopathy or active bleeding disorder; known allergy to antiseptic or phlebotomy materials; patient <18 years without legal guardian present (per Federal Decree‑Law No. 4 of 2016 on Medical Liability).
- Red Flags: Acute onset paralysis, rapidly progressive weakness, loss of bladder/bowel control, suicidal ideation, or severe depression — seek emergency care immediately. This genetic test is elective and not suitable for acute emergencies.
- If you experience severe anxiety or distress after receiving results, please contact our on‑call genetic counsellor via +971 54 548 8731.
Patient FAQ & Clinical Guidance
1. What exactly does the NT5C2 SPG45 NGS detect and how accurate is it?
This NGS panel sequences the complete NT5C2 gene, identifying single nucleotide variants, small insertions/deletions, and copy number changes with >99.9% diagnostic sensitivity for SPG45. The test is designed to provide a definitive molecular diagnosis.
2. How is the sample collected and is a hospital visit required?
We offer VIP home collection of 2–5 mL whole blood, saliva, or FTA card blood spot. A certified phlebotomist visits you between 8 AM and 11 PM daily, using temperature‑controlled cold‑chain logistics. No hospital visit is necessary.
3. How long do results take and will a doctor explain them to me?
Results are released within 3–4 weeks. A complementary telephonic clinical guidance session with a DHA‑licensed specialist is included to explain the findings and discuss next steps.
UAE Regulatory & Data Privacy Adherence
This diagnostic service complies with all applicable UAE federal laws and regulations:
- Personal Data Protection: Fully compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Governance: Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability: All sample collection and clinical procedures follow Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- DHA Licensing: Operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | NT5C2 Gene SPG45 Genetic Test (NGS Full Gene Sequencing) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (2–5 mL), Saliva, or FTA Card Blood Spot |
| Methodology Used | Next‑Generation Sequencing (NGS) – Full Gene Sequencing |
| ICD-10-CM Code | G11.4 (Hereditary spastic paraplegia) |
| LOINC Code | 21653-2 (Gene mutation analysis; DNA specimen) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians