Test Price
2,800 AED✅ Home Collection Available
NR1H4 Gene-Related Intrahepatic Cholestasis of Pregnancy (ICP) – Genetic Test in UAE | 2800 AED
Executive Summary
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Genetic Test. Clinical guidance with a DHA-licensed genetic counsellor to interpret your NR1H4 variant report. Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Facility License
DHA 1143
ISO 9001:2015
Cert: INT/EGQ/2509DA/3139
Test Overview & Methodology
This advanced NGS test comprehensively analyses the entire coding region of the NR1H4 gene (FXR receptor) to detect pathogenic variants linked to intrahepatic cholestasis of pregnancy (ICP), aiding precise diagnosis, personalised management and family planning. In the UAE, this DHA-accredited assay is performed under strict ISO 9001:2015 quality controls, with results ready in 3 to 4 weeks.
| Feature | Our Test (DHA-Certified) | Closest Alternative |
|---|---|---|
| Methodology | Full NGS (Next Generation Sequencing) of NR1H4 gene | Targeted PCR for a limited set of known hotspots |
| Diagnostic Yield | >99.9% sensitivity for all coding variants | May miss rare or novel mutations (sensitivity ~85%) |
| Turnaround Time | 3–4 Weeks | 2–3 Weeks |
| ISO 9001:2015 Accreditation | Yes (Cert: INT/EGQ/2509DA/3139) | Not always guaranteed |
| Home Collection | VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) | May use standard courier without cold chain |
Physician Insight & Safety Protocols
“Testing for NR1H4 gene variants must be interpreted in the wider clinical picture of gestational cholestasis; a negative result does not exclude ICP, and a positive result should prompt close maternal-fetal surveillance by a multidisciplinary team. I recommend all patients have genetic counselling before and after testing to fully understand the implications.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue or adjust any prescribed medication, including ursodeoxycholic acid, antihistamines, or antenatal supplements, without consulting your treating obstetrician or hepatologist.
Exclusion Criteria & Emergency Red Flags
- This test is not for acute, life-threatening presentations; seek immediate obstetric emergency care if you experience sudden severe right upper abdominal pain, jaundice, fetal distress or reduced movements.
- Test not validated for individuals under 18 years; prenatal testing for the fetus should be accompanied by expert fetal medicine consultation.
- Specimen must be collected by a trained professional; do not self-collect without guidance.
- Results may be affected by recent blood or marrow transfusions, chimerism, or certain medications—disclose your full clinical history.
Patient FAQ & Clinical Guidance
1. What is the NR1H4 gene test for intrahepatic cholestasis of pregnancy, and who should consider it?
The NR1H4 NGS test detects inherited mutations in the bile acid receptor gene that raise the risk of severe ICP, enabling early monitoring and tailored treatment for pregnant women with unexplained pruritus, elevated bile acids, or a family history of cholestasis.
2. How is the sample collected, and what preparation is needed?
A single blood draw or a dry FTA card with a few drops of blood is all that is required; no fasting is necessary, but a detailed family pedigree chart and a pre-genetic counselling session are mandatory to ensure accurate result interpretation.
3. Will my insurance cover the 2800 AED cost, and can I get home collection?
Direct insurance billing is verified instantly via WhatsApp at +971 54 548 8731, and our DHA-licensed phlebotomists provide VIP mobile phlebotomy and temperature-controlled cold-chain home collection daily from 8 AM to 11 PM.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted, access-controlled, and processed solely for diagnostic and counselling purposes.
Clinical & Logistical Metadata
| Test Name | NR1H4 Gene-Related Intrahepatic Cholestasis of Pregnancy (ICP) – Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood (EDTA) or Dried Blood Spot (FTA card). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM–11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene coding region analysis |
| ICD-10-CM Code | O26.61 |
| LOINC Code | 76386-8 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians