Test Price
2,800 AED✅ Home Collection Available
NPPA Gene (Atrial Fibrillation, Familial Type 6) Genetic Test in UAE | 2800 AED | DHA-Licensed DNA Labs UAE
Executive Summary & Core Metrics
Our ISO-Certified Promise
- 99.9% Diagnostic Sensitivity through ISO 9001:2015-certified NGS processing for full NPPA coding region analysis.
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Hospital-grade phlebotomist dispatched within 60 minutes (8 AM – 11 PM).
- Post-Test Clinical Guidance – Telephonic consultation with a DHA-licensed clinical geneticist to interpret your NPPA results.
- Insurance Support – Direct billing verification via WhatsApp at +971 54 548 8731.
- Price: 2,800 AED inclusive of genetic counselling report.
- Turnaround Time: 3–4 Weeks from sample receipt.
Test Overview & Methodology
The NPPA gene sequencing test uses next-generation sequencing (NGS) to detect pathogenic variants associated with familial atrial fibrillation type 6 (AFib6). By analyzing the entire coding region of the NPPA gene, which encodes atrial natriuretic peptide, this test provides critical insight for personalized cardiac monitoring, preventive strategies, and cascade screening of at-risk family members. The analysis covers single nucleotide variants (SNVs), small insertions/deletions, and copy number changes with high analytical sensitivity.
| Feature | Our Test – NPPA NGS (DHA-Licensed) | Closest Alternative – Single-Gene Sanger Sequencing |
|---|---|---|
| Method | Next-Generation Sequencing (full coding region) | Sanger sequencing (targeted exons only) |
| Variant Detection | 99.9% analytical sensitivity for SNVs, indels, and CNVs | Limited to known point mutations; may miss large rearrangements |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Price | 2,800 AED | ~3,500 AED |
| Accreditation | ISO 9001:2015, DHA Facility License #1143 | Often no local ISO certification |
Physician Insight & Safety Protocols
“As your DHA-licensed Consultant Medical Genetics (DHA Registration ID: 9294403), I emphasize that genetic testing for atrial fibrillation susceptibility must be interpreted alongside a thorough clinical evaluation, including ECG, echocardiogram, and family history. A pathogenic NPPA variant indicates an increased lifetime risk of atrial fibrillation but does not guarantee disease onset; a negative result does not exclude other genetic or acquired causes. This test is intended for individuals with a strong family history of early-onset AFib or unexplained lone AFib.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics
Medication & Clinical Advisory
Important Notice
Do not discontinue any prescribed anticoagulants, antiarrhythmics, or rate-control medications without consulting your treating physician. Genetic test results are not a substitute for medical management of existing conditions.
Exclusion Criteria & Emergency Red Flags
Safety Exclusion Criteria
- This test is not intended for acute emergency diagnosis of arrhythmia.
- Contraindicated if the patient is unable to provide valid informed consent.
- Cannot replace a comprehensive cardiologist evaluation, echocardiogram, or electrocardiogram.
Emergency Red Flags
If you experience sudden chest pain, syncope (fainting), severe palpitations, or difficulty breathing, seek immediate emergency room care – do not wait for genetic test results.
Patient FAQ & Clinical Guidance
1. What does the NPPA gene test detect, and how does it help?
The NPPA gene test identifies pathogenic mutations in the NPPA gene that cause familial atrial fibrillation type 6. The analysis screens for variants in the entire coding region of NPPA, which codes for atrial natriuretic peptide. A positive result indicates a higher lifetime risk of atrial fibrillation, allowing your cardiologist to implement early rhythm monitoring, lifestyle modifications, and cascade testing for family members.
2. Is any special preparation or fasting required for this DNA test?
No fasting is required. DNA can be extracted from a simple blood draw or a buccal swab. You may eat normally and continue your routine medications. Our phlebotomist collects a standard venous blood sample or a painless cheek swab during the home visit. The extracted DNA is stable at room temperature on the provided FTA card if direct blood processing is not possible.
3. How long until I receive my results and what support is provided?
Results are typically available within 3–4 weeks from sample receipt. Once the report is finalized, you will receive a secure electronic copy and a telephonic consultation with a DHA-licensed clinical geneticist who will explain the implications of any detected variant, its inheritance pattern, and recommended next steps, including referral to a cardiologist or electrophysiologist if needed.
4. Who should consider this genetic test?
This test is recommended for individuals with a strong family history of atrial fibrillation, especially if diagnosed before age 60, or those with lone atrial fibrillation of unknown cause. It may also be considered for patients with syncope or unexplained arrhythmias when a genetic etiology is suspected.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to UAE federal laws for data protection and health information security. All genetic data is handled in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent procedures follow the requirements of Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic data is encrypted, stored in secure servers within the UAE, and never shared with third parties without explicit written consent.
Clinical & Logistical Metadata
| Test Name | NPPA Gene Sequencing (Atrial Fibrillation, Familial Type 6) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) or buccal swab |
| Methodology Used | Next-Generation Sequencing (NGS) – full coding region analysis |
| ICD-10-CM Code | I48.0 (Paroxysmal atrial fibrillation), I48.1 (Persistent atrial fibrillation), I48.2 (Chronic atrial fibrillation), Z83.49 (Family history of other cardiovascular disease) |
| LOINC Code | 88878-8 (NPPA gene mutation analysis in Blood or Tissue by NGS) |
| DHA Facility License & Laboratory Address | License #1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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