Test Price
2,800 AED✅ Home Collection Available
NPHS2 Gene Nephrotic Syndrome Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity through ISO 15189-accredited NGS processing and variant interpretation.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance with a genetic counsellor to interpret results.
- Insurance: Direct Billing Verification via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
The NPHS2 NGS Test sequences the entire podocin gene to identify pathogenic variants causing steroid‑resistant nephrotic syndrome (SRNS), enabling precise diagnosis and family screening.
| Feature | Our Test: NPHS2 NGS (Full Gene Sequencing) | Closest Alternative: Targeted Mutation Panel / Renal Biopsy |
|---|---|---|
| Precision | 100% coverage of coding regions ±20 bp intronic flanks; detects all variant types (SNVs, indels, CNVs) | Limited to pre‑selected “hotspot” mutations; may miss rare or private variants |
| Methodology | Next‑Generation Sequencing (NGS) with Illumina NovaSeq, bioinformatic analysis via standardised pipelines | Sanger sequencing or high‑risk biopsy with histopathology; cannot detect all genetic causes |
| Turnaround Time | 3–4 Weeks (18–28 days) | 2–8 weeks depending on biopsy processing |
| Clinical Utility | Definitive genetic diagnosis; guides avoidance of ineffective steroids, renal prognosis, and familial risk assessment | Histological pattern may suggest, not confirm, genetic aetiology; cannot screen relatives |
Physician Insight & Safety Protocols
“The NPHS2 gene test provides definitive genetic diagnosis for steroid-resistant nephrotic syndrome, allowing targeted therapy and accurate family risk assessment. I recommend this test for any child presenting with unexplained nephrotic syndrome, especially when not responding to standard steroid therapy.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Important Medication Advisory
Do not discontinue prescribed medication (e.g., corticosteroids, diuretics, antihypertensives) without consulting your doctor. This test is for diagnostic purposes only and must not replace ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
- Exclusion criteria for home collection: Children < 2 years with poor venous access; active infection or fever; inability to provide adequate sample.
- Red flags requiring immediate emergency care (not sample collection): Sudden severe swelling (anasarca), respiratory distress, decreased urine output (< 0.5 mL/kg/h in children), or altered consciousness.
- In case of medical emergency, call 998 or visit the nearest UAE emergency department.
Patient FAQ & Clinical Guidance
1. What does the NPHS2 gene test detect?
Our NPHS2 NGS analyzes the entire podocin gene sequence to identify disease-causing variants responsible for steroid-resistant nephrotic syndrome, providing a definitive molecular diagnosis in just one sample.
2. Is fasting required before sample collection?
No fasting is necessary; the sample (whole blood or buccal swab) can be collected at any time. Routine medications do not affect DNA quality.
3. How are my genetic data protected under UAE law?
We strictly adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Genomic data is stored encrypted on on-shore servers with access limited to your authorised physician.
4. How long does it take to get results and does the report include family recommendations?
Results are issued within 3 to 4 weeks and include a detailed report with genetic counselling recommendations. A telephonic post-test session with a genetic counsellor is available.
UAE Regulatory & Data Privacy Adherence
Your trust matters. This test is conducted in full compliance with UAE federal laws:
- Data Protection: Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Data Security: Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety & Consent: Federal Decree-Law No. 4 of 2016 on Medical Liability.
All genetic data is encrypted, stored securely, and only shared with your treating physician upon your explicit consent.
Clinical & Logistical Metadata
| Test Name | NPHS2 Gene Sequencing (NGS) for Nephrotic Syndrome |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (18–28 days) |
| Sample Type / Matrix | Whole Blood (EDTA) or Buccal Swab |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina NovaSeq, Full Gene Sequencing |
| ICD-10-CM Code | N04.9 (Nephrotic syndrome, unspecified) |
| LOINC Code | 21665-8 (NPHS2 gene) |
| DHA Facility License & Address | DHA License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
Home Collection Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians