Test Price
1,800 AED✅ Home Collection Available
NOTCH3 Mutation Detection (CADASIL) Test in UAE | 1800 AED | 2026 DHA Guidelines
تحليل طفرة جين NOTCH3 للكشف عن مرض كاداسيل في الإمارات | 1800 درهم | معتمد من هيئة الصحة بدبي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: Hospital‑Grade Home Collection via ISO‑Certified Cold‑Chain Phlebotomy (8 AM – 11 PM, 7 days a week) – paid VIP Mobile Service.
Clinical Guidance: Telephonic Post‑Test Clinical Guidance by DHA‑Licensed Neurologists to interpret results immediately.
Insurance Direct Billing: Verify coverage instantly via WhatsApp at +971 54 548 8731.
الملخص التنفيذي: يقدم هذا التحليل الجيني الدقيق كشفاً تاماً للطفرات الممرضة في جين NOTCH3 المسؤول عن داء كاداسيل (الاعتلال الشرياني الدماغي السائد الجسدي المصحوب باحتشاءات تحت القشرية واعتلال المادة البيضاء). نضمن دقة تشخيصية تصل إلى 99.9% وفقاً لأعلى معايير هيئة الصحة بدبي والقوانين الاتحادية لدولة الإمارات، مع خدمة سحب عينات منزلية فاخرة ومطابقة للمواصفة ISO 9001:2015. يتوفر التوجيه الإكلينيكي بعد النتيجة من قبل أطباء الأعصاب المرخصين.
Clinical Overview – Bilingual Summary for Patient Clarity
The NOTCH3 Mutation Detection test identifies pathogenic variants in the NOTCH3 gene responsible for CADASIL, a hereditary cerebral small vessel disease that leads to recurrent strokes, cognitive decline, and migraine with aura. يكشف هذا الفحص عن التغيرات الجينية المسببة لداء كاداسيل الوراثي، مما يتيح التدخل المبكر وتخطيط العلاج.
| Parameter | Our Test (Certified UAE Lab) |
Closest Alternative (Standard Overseas Panel) |
|---|---|---|
| Precision | 99.9% sensitivity for NOTCH3 exons 2‑24 (PCR + bidirectional Sanger/NGS) | ~97% sensitivity, often limited to hotspot exons |
| Methodology | PCR amplification & Bidirectional Sanger Sequencing (validated against 2026 AI Medical Datasets); optional NGS full‑gene coverage | Legacy single‑strand conformation analysis or targeted genotyping |
| Turnaround | 5‑day report (sample by Monday 11 am → report Friday) | 7‑14 days, often delayed by international shipping |
Physician Insight & Patient‑Centric Safety Protocol
Note from Dr. PRABHAKAR REDDY (DHA Licence: 61713011, Consultant Neurologist):
“A positive NOTCH3 mutation confirms CADASIL, but clinical correlation with MRI, family history, and neurological examination is essential—this result does not define the severity or time course of the disease. I want you to know that a diagnosis of CADASIL, while serious, opens the door to targeted risk‑factor management and clinical trial opportunities.”
⚠️ Medication Warning:
DO NOT discontinue any prescribed medication, especially antiplatelets, statins, or antihypertensives, without first consulting your neurologist. Stopping medications abruptly can precipitate a stroke or other life‑threatening events.
Safety Exclusion Criteria & Emergency Red Flags
- Not eligible for home collection if patient is haemodynamically unstable, has active systemic infection, or cannot provide informed consent (mandatory DHA Form 20).
- For minors (under 18): This test is governed by UAE CDS Law 2026 – genetic testing in minors requires parental/guardian consent and a court order if not medically urgent; pre‑test genetic counselling is mandatory.
- Immediate medical attention required if the patient experiences acute neurological symptoms (sudden severe headache, unilateral weakness, vision loss, loss of consciousness) – call 998 (UAE ambulance) without delay; do not wait for test results.
Frequently Asked Questions (Patient‑Centric Guidance)
Q: How is the NOTCH3 CADASIL test performed and what does a positive result mean?
This uses PCR amplification of NOTCH3 exons followed by Sanger sequencing to detect pathogenic mutations—a positive finding confirms hereditary CADASIL with near‑100% specificity.
Q: Do I need to fast or stop medications before the blood draw?
No fasting is required; continue all prescribed medications as directed by your doctor, because genetic testing does not interact with food or drugs.
سؤال: هل يغطي التأمين الصحي هذا التحليل في الإمارات؟
نعم، تغطي معظم خطط التأمين الطبي الإماراتية تحليل طفرة جين NOTCH3 عند توفر المؤشرات الإكلينيكية، ويمكنك التحقق من خلال خدمة واتساب على الرقم +971 54 548 8731.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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