Test Price
1,800 AED✅ Home Collection Available
NOTCH3 Mutation Detection (CADASIL) Test in UAE | 1800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance by DHA-Licensed Genetics specialists to interpret results immediately.
Insurance Direct Billing: Verify coverage instantly via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The NOTCH3 Mutation Detection test identifies pathogenic variants in the NOTCH3 gene responsible for CADASIL, a hereditary cerebral small vessel disease that leads to recurrent strokes, cognitive decline, and migraine with aura.
| Parameter | Our Test (Certified UAE Lab) |
Closest Alternative (Standard Overseas Panel) |
|---|---|---|
| Precision | 99.9% sensitivity for NOTCH3 exons 2-24 (PCR + bidirectional Sanger/NGS) | ~97% sensitivity, often limited to hotspot exons |
| Methodology | PCR amplification & Bidirectional Sanger Sequencing (validated against high-resolution datasets); optional NGS full-gene coverage | Legacy single-strand conformation analysis or targeted genotyping |
| Turnaround | 5-day report (sample by Monday 11 am → report Friday) | 7-14 days, often delayed by international shipping |
Physician Insight & Safety Protocols
Note from Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“A positive NOTCH3 mutation confirms CADASIL, but clinical correlation with MRI, family history, and neurological examination is essential—this result does not define the severity or time course of the disease. I want you to know that a diagnosis of CADASIL, while serious, opens the door to targeted risk-factor management and clinical trial opportunities.”
Safety Advisory: Medication Precautions
DO NOT discontinue any prescribed medication, especially antiplatelets, statins, or antihypertensives, without first consulting your neurologist.
Stopping medications abruptly can precipitate a stroke or other life-threatening events. Always consult your physician before making any changes.
Safety Exclusion Criteria & Emergency Red Flags
- Home Collection Eligibility: Not eligible for home collection if patient is haemodynamically unstable, has active systemic infection, or cannot provide informed consent (mandatory DHA Form 20).
- For Minors: Genetic testing in minors requires parental/guardian consent and pre-test genetic counselling is mandatory as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Emergency Symptoms: If patient experiences acute neurological symptoms (sudden severe headache, unilateral weakness, vision loss, loss of consciousness) – call 998 (UAE ambulance) without delay; do not wait for test results.
Patient FAQ & Clinical Guidance
1. How is the NOTCH3 CADASIL test performed and what does a positive result mean?
This test uses PCR amplification of NOTCH3 exons followed by Sanger sequencing to detect pathogenic mutations—a positive finding confirms hereditary CADASIL with near-100% specificity.
2. Do I need to fast or stop medications before the blood draw?
No fasting is required; continue all prescribed medications as directed by your doctor, as genetic testing does not interact with food or drugs.
3. Does health insurance cover this test in the UAE?
Yes, most UAE health insurance plans cover the NOTCH3 gene mutation test when clinical indications are present. You can verify coverage directly via our WhatsApp service at +971 54 548 8731.
UAE Regulatory & Data Privacy Adherence
Your data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
All genetic results are stored on encrypted servers within the UAE, accessible only to authorized healthcare professionals.
Clinical & Logistical Metadata
| Test Name | NOTCH3 Mutation Detection (CADASIL) |
| Price (AED) | 1800 AED |
| Turnaround Time | 5 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) |
| Methodology Used | PCR Amplification & Bidirectional Sanger Sequencing |
| ICD-10-CM Code | I67.85 – Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) |
| LOINC Code | 94212-5 – NOTCH3 gene mutation analysis in Blood or Tissue by Sequencing |
| DHA Facility License & Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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