Test Price
2,800 AED✅ Home Collection Available
NOS3 (eNOS) Gene Alzheimer's Disease Susceptibility Test (NGS) in UAE2800 AED
Executive Summary & Core Metrics
Premium Single‑Gene NGS – 99.9% Diagnostic Sensitivity
- Guaranteed Accuracy: Dual‑validated NGS pipeline under ISO 9001:2015 (cert: INT/EGQ/2509DA/3139).
- Superior Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection, available daily from 8 AM to 11 PM.
- Clinical Integration: Post‑test telephonic guidance with a DHA‑licensed clinical geneticist to interpret your NOS3 result.
- Insurance Ease: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The NOS3 gene encodes endothelial nitric oxide synthase (eNOS), a critical enzyme for cerebral blood flow regulation. This NGS test analyzes the full coding region and splice sites to identify variants linked to elevated Alzheimer’s disease susceptibility, enabling neurologists, clinical geneticists, and functional medicine practitioners to personalize risk reduction strategies.
| Feature | Our NOS3 NGS Test | Standard Alternative |
|---|---|---|
| Methodology | High‑throughput Next Generation Sequencing (with CNV calling) | Targeted Sanger sequencing (limited to known hotspots) |
| Variant Coverage | Complete coding exons ±20 bp intronic flanks – detects rare/novel variants | Only preselected SNP positions; may miss private mutations |
| Analytical Sensitivity | ≥99.9% for variant calls at >20% allele fraction | ~95% for Sanger; lower for low‑level mosaicism |
| Turnaround Time | 3–4 weeks (ISO‑certified cold chain) | 6–8 weeks (often with outsourced batch processing) |
Physician Insight & Safety Protocols
“As a DHA‑licensed clinical geneticist, I view the NOS3 susceptibility test as a powerful tool for risk stratification – not a diagnostic crystal ball. A positive variant should be integrated with family history, imaging, and neuropsychological assessment to guide preventive neurology, never replace clinical judgment.”
Medication Safety Advisory
🛑 Important Medication Warning
Do not discontinue, adjust, or start any prescribed medication (including Alzheimer’s therapies, antihypertensives, or supplements) based solely on this genetic result. Always consult your treating physician.
Patient Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Inability to provide written informed consent (or guardian consent for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability)
- Active psychiatric crisis requiring immediate intervention
- Specimen hemolysis, insufficient DNA yield, or contamination after two collection attempts
- Prenatal/pediatric predictive testing for adult‑onset condition without independent genetic counselling
ER Red Flags (seek emergency care)
- Acute confusion, sudden severe headache, or focal neurological deficit
- Transient loss of consciousness or seizure
- Psychotic symptoms or suicidal ideation
- This test is not a substitute for urgent neurological evaluation
Patient FAQ & Clinical Guidance
1. What is the NOS3 gene and how does it relate to Alzheimer's disease?
The NOS3 gene encodes endothelial nitric oxide synthase, a protein that controls cerebral blood flow and oxidative stress; specific variants increase susceptibility to late‑onset Alzheimer’s disease and influence cognitive decline.
2. How is the sample collected and when will I receive my results?
A certified DHA‑licensed phlebotomist collects a small blood sample (or a single drop on an FTA card) at your home at any time between 8 AM and 11 PM via VIP Mobile Phlebotomy; DNA is sequenced via NGS and the final report is delivered within 3 to 4 weeks.
3. Is this genetic test suitable for children under 18 years?
Under Federal Decree-Law No. 4 of 2016 on Medical Liability, predictive testing for adult‑onset conditions like Alzheimer's is generally not performed on minors unless there is a clear clinical indication and formal consent from a legal guardian.
4. What do the results mean for my risk of Alzheimer's disease?
A positive result indicates a genetic variant that may increase susceptibility to Alzheimer’s, but it is not deterministic. Risk is influenced by many genes and lifestyle factors. Your clinical geneticist will provide a comprehensive risk interpretation.
5. How is my genetic data protected?
Your data is processed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Anonymized results are stored on encrypted servers with restricted access.
UAE Regulatory & Data Privacy Adherence
Your Privacy & Compliance
DNA Labs UAE operates under DHA Facility License Number 1143 and strictly adheres to the following federal laws:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governs the collection and processing of your genetic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – ensures secure handling of electronic health records.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – provides legal safeguards for clinical testing, informed consent, and patient safety.
Your sample is processed in a CAP‑accredited, CLIA‑certified laboratory with strict confidentiality protocols.
Clinical & Logistical Metadata
| Test Name | NOS3 (eNOS) Gene Alzheimer’s Disease Susceptibility Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood or FTA card (buccal swab acceptable after consultation) |
| Methodology Used | Next Generation Sequencing (NGS) with CNV calling |
| ICD-10-CM Code | Z13.82 (Encounter for screening for genetic disease) |
| LOINC Code | 21632-5 (NOS3 gene mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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