Test Price
2,800 AED✅ Home Collection Available
NLRP12 Gene Sequencing for Cold Autoinflammatory Syndrome Type 2 (CAPS2) in UAE | 2800 AED | 2026 DHA Guidelines
تحليل تسلسل جين NLRP12 لمتلازمة الالتهاب الذاتي البارد من النوع الثاني في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Why Choose Our Test?
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
يُقدّم هذا التحليل الجيني المتقدم تشخيصًا دقيقًا لمتلازمة الالتهاب الذاتي البارد من النوع الثاني المرتبطة بجين NLRP12، معتمدًا من هيئة الصحة بدبي ومعيار الآيزو 9001:2015 لضمان أعلى مستويات الجودة.
Test Overview
This next-generation sequencing (NGS) test analyzes the entire coding region of the NLRP12 gene to identify pathogenic variants associated with Cold Autoinflammatory Syndrome Type 2 (CAPS2), a hereditary periodic fever syndrome presenting with cold-induced urticaria and systemic inflammation. يكشف هذا الاختبار الطفرات الجينية المسببة لمتلازمة الالتهاب الذاتي البارد من النوع الثاني بدقة عالية.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | >99.9% base-level accuracy with deep coverage | High accuracy but limited to targeted regions |
| Methodology | Next Generation Sequencing (NGS) | Sanger Sequencing |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Variant Detection | Detects SNVs, indels, CNVs, and deep intronic variants | Misses large deletions, duplications, and deep intronic variants |
Physician Insight & Safety Protocol
Note from Dr. Prabhakar Reddy (DHA License: 61713011): "As a clinical expert, I emphasize that while this NGS test provides highly accurate genetic data, it must be interpreted alongside your full clinical picture, family history, and inflammatory markers. A positive variant does not always confirm active disease—consult your dermatologist or rheumatologist for personalized management. Please, never self-interpret results."
⚠️ Medication Warning: Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria & Emergency Red Flags
- Recent allogeneic hematopoietic stem cell transplant (interferes with germline DNA analysis).
- Inability to provide informed consent or comply with phlebotomy requirements.
- Known somatic mosaicism may necessitate additional tissue testing.
🚨 Red Flags: If you experience high fever, severe rash, joint swelling, or signs of systemic inflammation, seek urgent medical care—genetic testing should not delay clinical intervention.
Frequently Asked Questions
Q: What does the NLRP12 genetic test detect and how is it used?
Snippet killer answer (first sentence): This test detects pathogenic variants in the NLRP12 gene causing cold autoinflammatory syndrome type 2, guiding diagnosis and treatment.
The test sequences the entire NLRP12 gene using NGS, identifying point mutations, deletions, and duplications linked to CAPS2. A positive result can confirm a clinical diagnosis and inform management strategies, including targeted therapies.
س: ماذا يكشف تحليل جين NLRP12 وكيف يُستخدم؟
يكشف هذا الاختبار الطفرات المسببة لمتلازمة الالتهاب الذاتي البارد من النوع الثاني، ويساعد الأطباء في تأكيد التشخيص وتوجيه العلاج.
Q: How should I prepare for the NLRP12 genetic test, and is a genetic counselling session required?
Snippet killer: A genetic counselling session is mandatory to discuss family history, inheritance, and implications before sample collection.
You need to provide a blood sample (or buccal swab/extracted DNA) and undergo pre-test counselling where a certified genetic counsellor draws a pedigree chart of affected family members. No fasting is required, but blood collection follows standard hygiene. The session ensures you understand potential findings and their impact.
س: كيف أستعد للاختبار الجيني NLRP12، وهل جلسة الاستشارة الوراثية ضرورية؟
جلسة الاستشارة الوراثية إلزامية لمناقشة التاريخ العائلي والآثار المترتبة قبل جمع العينة.
Q: How long does it take to get results, and what happens after?
Snippet killer: Results are delivered in 3 to 4 weeks, followed by a telephonic consultation for personalized interpretation.
Once your NGS analysis is complete, our clinical team will call you to explain the findings, discuss any variants of uncertain significance, and recommend follow-up steps with your specialist. The report includes a clear risk assessment and clinical correlation.
س: كم تستغرق النتائج وماذا يحدث بعد ذلك؟
تظهر النتائج خلال 3 إلى 4 أسابيع، يليها استشارة هاتفية لتفسيرها شخصيًا.
Regulatory Compliance: This adheres to UAE Federal Decree-Law No. 41 of 2024 (Art. 87), CDS Law 2026 (minors genetic testing requires legal guardian consent), and UAE PDPL data privacy standards. The laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139). All data is processed in a secure, encrypted environment.
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