Test Price
2,800 AEDโ Home Collection Available
NKX2-1 Gene Hereditary Benign Chorea Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Our advanced genetic test provides comprehensive analysis of the NKX2-1 gene using next-generation sequencing (NGS), detecting pathogenic mutations responsible for hereditary benign chorea. This test delivers over 99.9% diagnostic sensitivity with full compliance to UAE regulations, including Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere strictly to Federal Decree-Law No. 4 of 2016 on Medical Liability. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
Accuracy Guarantee
99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection daily from 8 AM to 11 PM.
Clinical Guidance
Telephonic Post-Test Clinical Guidance in Result Interpretation.
Insurance
Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The NKX2-1 gene test (also known as TTF-1 gene) uses next-generation sequencing (NGS) to detect pathogenic mutations causing hereditary benign chorea, a rare movement disorder. This analysis provides precise molecular diagnosis, guides neurological management, and assesses familial risk in the UAE population.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | Full NGS coverage of NKX2-1 exons ยฑ20bp intronic borders | Targeted mutation panel (only known hotspots) |
| Method | NGS with orthogonal Sanger confirmation | Sanger sequencing only |
| Speed | 3โ4 Weeks (including clinical report by DHA-licensed geneticist) | 5โ6 Weeks (standard external reference lab) |
Physician Insight & Safety Protocols
โHereditary benign chorea can present with subtle clinical features that overlap with other hyperkinetic movement disorders. A positive NKX2-1 finding should always be interpreted within the full context of a detailed neurological exam, three-generation family pedigree, and thyroid function studies. Pre-test genetic counselling is essential for at-risk adult family members considering predictive testing. Never discontinue prescribed medications without direct consultation with your treating neurologist.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Safety Notice
Do not adjust or stop any prescribed medications without explicit guidance from your treating physician. Abrupt withdrawal may precipitate worsening of chorea or unmask underlying neurological instability.
Exclusion Criteria & Red Flags
- Uncontrolled epileptic seizures unrelated to chorea (require stabilization first).
- Acute psychiatric episode with impaired capacity to consent.
- Severe coagulopathy precluding safe blood draw.
- ER Red Flags: Sudden onset of severe chorea with altered consciousness, respiratory distress, or thyroid storm โ seek immediate emergency care.
Patient FAQ & Clinical Guidance
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Snapshot: This NGS test identifies pathogenic variants in the NKX2-1 gene with over 99.9% accuracy, confirming the molecular diagnosis of hereditary benign chorea. The result helps differentiate this benign condition from progressive neurodegenerative choreas and informs recurrence risk counselling for family members.
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Snapshot: Yes, one drop of blood on an FTA card is a validated sample type, offering convenient home collection with the same analytical sensitivity as venous whole blood. Our VIP Mobile Phlebotomy service can also collect a standard venous sample at your residence.
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Snapshot: You will be scheduled for a teleconsultation with a DHA-licensed genetic counsellor who will draw a detailed family pedigree and explain the implications of possible results, including the small chance of variants of uncertain significance. No specific physical preparation is needed, but having family medical history information available is helpful.
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Snapshot: Results are typically available within 3โ4 weeks from sample receipt. A comprehensive clinical report signed by a DHA-licensed consultant medical geneticist will be delivered electronically via secure portal and can be explained during a follow-up teleconsultation.
1. What is the purpose of the NKX2-1 gene test for hereditary benign chorea?
2. Can I use a dried blood spot (FTA card) for this test?
3. How do I prepare for the genetic counselling session before the test?
4. What is the turnaround time for results, and how will I receive them?
UAE Regulatory & Data Privacy Adherence
Your Data, Your Rights
DNA Labs UAE strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed solely for diagnostic purposes with your explicit written consent. You have the right to access, rectify, and request deletion of your data in accordance with PDPL. For data subject requests, contact our Data Protection Officer at dpo@dnalabsuae.com.
Clinical safety and patient consent procedures are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. We maintain full compliance with DHA standards for genetic testing and result disclosure.
Clinical & Logistical Metadata
| Test Name | NKX2-1 Gene Hereditary Benign Chorea Genetic Test |
| Price (AED) | 2800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | G25.5 (Chorea) |
| LOINC Code | 49266-4 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab Branding: DNA Labs UAE |
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