Test Price
2,600 AED✅ Home Collection Available
Next-Generation Sequencing (NGS) for Dementia Genetic Testing in UAE | 2600 AED
Executive Summary & Core Metrics
The Next-Generation Sequencing Dementia Panel at DNA Labs UAE screens for pathogenic variants in genes associated with Alzheimer disease, frontotemporal dementia, Lewy body dementia, and other neurodegenerative disorders. With 99.9% diagnostic sensitivity confirmed by Sanger sequencing, the test provides definitive genetic insights to guide clinical management. All processing is performed at our ISO 9001:2015 accredited facility under DHA oversight.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity (NGS + Sanger confirmation) via ISO‑accredited processing.
- Premium Logistics: Hospital‑grade home collection with ISO‑certified cold‑chain (2–8°C) and VIP mobile phlebotomy.
- Clinical Guidance: Telephonic post‑test clinical counselling by a DHA‑licensed genetics consultant for result interpretation.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This comprehensive NGS panel sequences all known dementia‑associated genes with copy number variant detection, delivering definitive diagnostic accuracy exceeding routine APOE genotyping alone. The methodology includes Illumina next‑generation sequencing with confirmatory Sanger sequencing for all clinically significant variants. Bioinformatics analysis uses validated pipelines compliant with ACMG guidelines.
| Feature | Our Test (NGS Dementia Panel) | Closest Alternative (Targeted Genotyping) |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity, full gene coverage + CNV analysis | ~85% sensitivity, limited variant types |
| Methodology | NGS (Illumina) with Sanger confirmatory sequencing | Array‑based genotyping or single‑gene Sanger |
| Turnaround Time | 40 working days (meticulous bioinformatics) | 20–30 working days (limited analysis) |
Physician Insight & Safety Protocols
“This NGS panel is an essential tool for uncovering the genetic basis of early-onset dementia. However, results must always be interpreted alongside clinical and imaging data. A positive finding guides surveillance and family counselling, but does not replace ongoing specialist care. Patients should discuss all results with their treating physician before making any health decisions.”
— Ms. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration: 9294403
Medication Safety Advisory
Do not discontinue or modify any prescribed medication (e.g., cholinesterase inhibitors, memantine) without consulting your treating physician. Genetic results may inform long‑term strategy but are never a substitute for ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Prior bone marrow transplant or history of allogeneic transfusion within the last 7 days (may cause chimerism).
- Exclusion: Inability to provide mandatory signed Whole Exome Sequencing Consent Form (Form 37).
- Red Flag: Sudden onset of severe headache, confusion, or focal neurological deficits during the waiting period — seek emergency care; genetic testing does not rule out acute intracranial events.
Patient FAQ & Clinical Guidance
1. How does this test differ from standard genetic screening for Alzheimer’s?
This NGS panel sequences all known dementia‑associated genes with copy number variant detection, delivering definitive diagnostic accuracy exceeding routine APOE genotyping alone. It detects rare mutations in genes such as APP, PSEN1, GRN, and MAPT, making it a comprehensive diagnostic tool.
2. Is home blood collection safe and how is the sample kept stable?
Certified phlebotomists use sterile venipuncture and immediately place EDTA tubes in validated 2–8°C transport boxes, preserving DNA integrity without freezing. The ISO‑certified cold chain ensures sample stability for up to 72 hours during transit to the laboratory.
3. Will my insurance cover this test and how do I confirm?
Our team validates coverage directly with your insurer via WhatsApp, and we will notify you of any co‑payment before sample collection. Coverage is verified using your insurance card details submitted through WhatsApp at +971 54 548 8731.
UAE Regulatory & Data Privacy Adherence
This service fully complies with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring patient data confidentiality and secure processing.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing electronic health records and telemedicine.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – establishing informed consent and clinical safety standards.
- DHA Health Regulation and ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139).
All genetic testing requires signed informed consent (Form 37) and is conducted under DHA‑licensed supervision.
Clinical & Logistical Metadata
| Test Name | Next‑Generation Sequencing (NGS) for Dementia Genetic Panel |
| Price (AED) | 2600 AED |
| Turnaround Time | 40 working days |
| Sample Type / Matrix | Whole blood (10 mL, 5 mL min.) in 2 Lavender Top EDTA tubes. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next‑Generation Sequencing (Illumina) with Sanger confirmatory sequencing and CNV analysis |
| ICD-10-CM Code | G30.9 (Alzheimer disease, unspecified), G31.09 (Frontotemporal dementia), G31.83 (Dementia with Lewy bodies) |
| LOINC Code | 89359-8 (Dementia NGS panel) |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians