Test Price
2,800 AED✅ Home Collection Available
MYH6 Gene (Sick Sinus Syndrome Type 3) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
This advanced genetic test employs Next-Generation Sequencing (NGS) to detect pathogenic variants in the MYH6 gene associated with sick sinus syndrome type 3, a rare inherited arrhythmia disorder. The analysis achieves a 99.9% diagnostic sensitivity via ISO‑accredited processing and includes post‑result telephonic genetic counseling, hospital‑grade home collection with temperature‑controlled cold‑chain logistics, and direct insurance billing verification via WhatsApp. All data is handled in full compliance with UAE Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning health information technology.
Test Overview & Methodology
The MYH6 gene test uses Illumina NovaSeq next‑generation sequencing to comprehensively analyze all coding exons, splice sites, and flanking intronic regions of the MYH6 gene. Bioinformatic variant interpretation follows ACMG/AMP guidelines, providing high‑confidence results for clinical decision‑making. The method offers superior coverage (>100x mean depth) compared to traditional Sanger sequencing, which is limited to targeted exons and may miss deep intronic or regulatory variants.
| Parameter | Our Test (MYH6 NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | Full gene sequencing · 99.9% analytical sensitivity | Targeted exon analysis only · may miss deep intronic/regulatory variants |
| Method | NGS (Illumina NovaSeq) with bioinformatic ACMG interpretation | Sanger sequencing · limited multiplexing |
| Speed | 3–4 Weeks guaranteed | 6–8 Weeks typical |
| Coverage | >100x mean depth across all coding & splice regions | Variable · manual analysis |
Physician Insight & Safety Protocols
“A MYH6 NGS result must always be interpreted within the full clinical and family context. A positive finding does not guarantee symptom development, while a negative result does not exclude all cardiac risk. This test is an invaluable piece of the diagnostic puzzle when correlated with electrocardiographic and Holter monitoring data.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
⚠️ Do not discontinue prescribed medication or modify your treatment plan without consulting your supervising physician.
Exclusion Criteria & Emergency Red Flags
- Minors (under 18) without court‑approved parental consent as per UAE Federal Law No. 2 of 2019 concerning health information technology and applicable family court rulings.
- Individuals unable to provide informed consent or with active febrile illness at the time of blood draw.
- Emergency Red Flags: If you experience syncope, severe dizziness, chest pain, or heart rate below 40 bpm, seek immediate emergency care — do not wait for genetic test results.
- This test does not replace real‑time cardiological evaluation; it is a predictive/confirmatory genetic assay.
Patient FAQ & Clinical Guidance
1. What is an MYH6 gene test for sick sinus syndrome, and who should consider it?
A MYH6 genetic test sequences the entire MYH6 gene to identify pathogenic mutations responsible for sick sinus syndrome type 3, a hereditary disorder of the heart’s natural pacemaker. It is recommended for patients with unexplained bradycardia, sinus node dysfunction, or a family history of early‑onset sinus node disease, as well as for asymptomatic family members after a confirmed familial mutation has been identified.
2. How is the sample collected, and what preparation is required?
A hospital‑grade phlebotomist visits your home (8 AM–11 PM) to draw one 4 mL EDTA whole blood sample or collect a finger‑prick dried blood spot on an FTA card; no fasting is needed. Avoid taking any dietary supplements containing biotin for 48 hours before collection, as it may interfere with the sequencing biochemistry.
3. How long does the result take and what is its accuracy?
The result for complete MYH6 gene sequencing takes between three to four weeks, with a diagnostic sensitivity exceeding 99.9% covering all coding and splice regions. Genetic variants are analyzed per ACMG guidelines, and telephonic genetic counseling is provided in both Arabic and English after the final report is issued.
UAE Regulatory & Data Privacy Adherence
This test and its associated data handling comply with UAE Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and informed consent follow Federal Decree‑Law No. 4 of 2016 on Medical Liability. Laboratory operations are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). The service is provided by DNA Labs UAE under DHA Facility License 1143.
Clinical & Logistical Metadata
| Test Name | MYH6 Gene (Sick Sinus Syndrome Type 3) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or dried blood spot (FTA card) |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina NovaSeq |
| ICD-10-CM Code | I49.5 (Sick sinus syndrome) |
| LOINC Code | 102384-2 (MYH6 gene targeted mutation analysis) |
| DHA Facility License & Lab Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians