Test Price
2,800 AED✅ Home Collection Available
MYH3 Gene Distal Arthrogryposis Type 2B (DA2B) NGS Genetic Test | DNA Labs UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139). Our laboratory employs LC‑MS/MS‑validated variant calling to eliminate false positives.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection. Samples transported at 2–8°C with GPS-tracked couriers. Service available daily from 8 AM to 11 PM.
Clinical Guidance: Complimentary telephonic post-test clinical guidance in result interpretation by a DHA-licensed genetic counsellor. Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The MYH3 NGS panel detects pathogenic variants in the myosin heavy chain 3 gene responsible for Distal Arthrogryposis Type 2B (DA2B), a congenital contracture syndrome. This test provides definitive molecular diagnosis for families and guides management across musculoskeletal, dermatological, and immunological domains.
| Feature | Our Test (ISO/DHA Certified) | Closest Alternative (Standard Gene Panel) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) with full coding region coverage and copy number variation analysis | Targeted Sanger sequencing of selected exons only |
| Analytical Sensitivity | >99.9% (single nucleotide variants & indels) | ~95% (point mutations only) |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
Physician Insight & Safety Protocols
“As a consultant in medical genetics, I emphasize that this NGS result must be interpreted within the context of a complete three-generation pedigree and thorough clinical examination. A negative result does not entirely exclude all forms of distal arthrogryposis, while a positive result confirms a molecular etiology but necessitates correlation with phenotypic findings. Genetic counselling is an indispensable step prior to making any reproductive or therapeutic decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Management Advisory
Do not discontinue or modify any prescribed medication, including muscle relaxants or anti‑inflammatory drugs, without consulting your treating physician. Genetic test results are intended to inform clinical management, not to replace routine medical follow-up or emergency care protocols.
Safety Exclusion & Clinical Red Flags
- This test is not indicated for asymptomatic minors without formal consent from a legal guardian and prior genetic counselling.
- Do not proceed if you are currently pregnant or have recently received an allogeneic blood transfusion, as this may interfere with DNA extraction and lead to erroneous results.
- Seek immediate emergency care if you or your child develops acute respiratory distress, severe joint pain, or sudden inability to move a limb. These symptoms are unrelated to the testing procedure but require urgent clinical assessment.
Patient FAQ & Clinical Guidance
1. What is the turnaround time for the MYH3 genetic test in Dubai?
The standard turnaround time for the MYH3 Distal Arthrogryposis Type 2B NGS test is 3 to 4 weeks from the date the sample reaches our ISO‑accredited laboratory. This includes DNA extraction, sequencing, bioinformatics analysis, and a rigorous clinical review by our genetics team.
2. What sample types are accepted? Can I collect the sample at home?
We accept peripheral whole blood, extracted DNA, or a single blood spot on an FTA card. A trained phlebotomist can collect the sample at your home or office anywhere in the UAE from 8 AM to 11 PM, ensuring strict temperature-controlled cold-chain integrity.
3. Is genetic counselling mandatory before undergoing this test?
Yes, a pre‑test genetic counselling session is mandatory. This session allows our consultant to document a detailed pedigree of family members affected by MYH3‑related arthrogryposis and ensures that you fully understand the implications of both positive and negative results for yourself and your family.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Compliance: DNA Labs UAE strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Genetic data is encrypted and stored within UAE sovereign infrastructure with zero cross-border transfer without explicit patient consent.
Clinical & Logistical Metadata
| Test Name | MYH3 Gene Distal Arthrogryposis Type 2B (DA2B) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood, Extracted DNA, or FTA Card Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) with Full Coding Region Coverage & CNV Analysis |
| ICD-10-CM Code | Q74.3 |
| LOINC Code | 77998-9 |
| DHA Facility License & Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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