Test Price
2,800 AEDโ Home Collection Available
MYD88 Gene Sequencing Test for Recurrent Pyogenic Bacterial Infections Due to MYD88 Deficiency | DNA Labs UAE
Executive Summary & Core Metrics
Diagnostic Accuracy: 99.9% Sensitivity via ISO 9001:2015 Certified NGS
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM)
Clinical Guidance: Telephonic Post-Test Genetic Counselling with DHA-Licensed Consultant Medical Genetics
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
MYD88 gene sequencing by Next-Generation Technology diagnoses the rare autosomal recessive primary immunodeficiency responsible for recurrent severe pyogenic bacterial infections. This definitive molecular assay delivers 99.9% diagnostic sensitivity, guides targeted antibiotic prophylaxis and immunoglobulin therapy, and enables cascade family screening. All testing is performed at DNA Labs UAE, DHA-licensed facility No. 1143, Dubai Healthcare City.
DHA Facility License: 1143 | ISO 9001:2015 Cert: INT/EGQ/2509DA/3139 | Laboratory Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Test Overview & Methodology
The MYD88 Gene NGS Test analyses the entire coding region of the MYD88 gene to detect pathogenic variants causing MYD88 deficiency, an autosomal recessive primary immunodeficiency leading to recurrent, severe pyogenic bacterial infections. This advanced genetic test enables definitive diagnosis, guides targeted antibiotic prophylaxis and immunoglobulin therapy, and facilitates family screening for proactive healthcare management. Clinical correlation with immunological phenotype and family pedigree is essential for accurate variant interpretation.
| Parameter | Our NGS Test | Sanger Sequencing (Alternative) |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity | ~99% detection rate |
| Methodology | NextโGeneration Sequencing (full gene) | Targeted exon Sanger sequencing |
| Turnaround Time | 3โ4 Weeks | 6โ8 Weeks |
| Price (AED) | 2,800 | ~2,000 (limited analysis) |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics, I see families struggling with unexplained recurrent pyogenic infections that standard workups fail to clarify. A definitive molecular diagnosis of MYD88 deficiency transforms the clinical trajectory โ it allows us to replace empirical antibiotic cycles with precise prophylaxis and immunoglobulin therapy, significantly reducing infection burden and hospitalisations. I emphasise that genetic results must always be interpreted alongside immunological phenotyping and family segregation analysis before finalising any management plan."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Altering prophylactic antibiotics or immune-modulating therapy on your own can trigger life-threatening infections. Any changes to treatment must be supervised by your immunologist or infectious disease specialist.
Patient Exclusion Criteria
- Active unstable infection requiring hospitalisation.
- Inability to provide informed consent.
- Children under 2 years without prior paediatric genetic counselling.
Emergency Red Flags โ Go to ER Immediately
- Fever >38.5ยฐC with chills, hypotension, or confusion.
- Rapidly spreading skin abscess or cellulitis with systemic signs.
- Difficulty breathing or bluish lips.
These signs suggest sepsis or severe infection. Do not wait for sample collection; seek emergency care.
Patient FAQ & Clinical Guidance
1. What is MYD88 deficiency and how does the NGS test detect it?
MYD88 deficiency is a rare inherited autosomal recessive disorder that impairs immune defence against pyogenic bacteria, leading to recurrent severe infections such as pneumonia, sinusitis, skin abscesses, and meningitis. The NGS test examines all coding exons and splice junctions of the MYD88 gene to identify pathogenic mutations with 99.9% sensitivity. This comprehensive approach distinguishes MYD88 deficiency from other primary immunodeficiencies with overlapping clinical features.
2. How do I prepare for the MYD88 genetic test?
Preparation requires a clinical history review and a genetic counselling session to document the family pedigree for accurate variant interpretation. No fasting is necessary. Our VIP mobile phlebotomy team collects a peripheral whole blood sample at your home between 8 AM and 11 PM, using temperature-controlled cold-chain logistics to ensure sample integrity. Alternatively, you may visit our Dubai Healthcare City laboratory for collection.
3. What does a negative result mean for my child's recurrent infections?
A negative result indicates no pathogenic MYD88 variant was detected. However, other primary immunodeficiencies (e.g., IRAK4 deficiency, NLRP3-associated disorders) may still cause recurrent pyogenic infections. Further immunological investigations โ including IgG subclass levels, complement studies, and lymphocyte subset analysis โ are recommended. Genetic counselling helps interpret the result within the family context and guidesไธไธๆญฅ testing if clinically warranted.
4. How long does it take to receive results and how are they delivered?
Turnaround time is 3โ4 weeks from sample receipt. Results are delivered electronically via a secure patient portal and reviewed in a telephonic post-test genetic counselling session with our DHA-licensed Consultant Medical Genetics. A hard copy of the molecular report is also available upon request. All reports include variant classification per ACMG/AMP guidelines.
UAE Regulatory & Data Privacy Adherence
Legal & Privacy Compliance
All genetic testing at DNA Labs UAE is conducted in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ ensuring your genetic and health data is processed lawfully, stored securely, and never shared without explicit consent.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ governing the secure handling of electronic health records and telemedicine interactions.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ establishing the framework for clinical safety, informed consent, and physician accountability throughout the testing pathway.
Your DNA sample is processed in our ISO 9001:2015 certified laboratory under strict chain-of-custody protocols. Results are released only to the ordering physician and the patient following verified identity confirmation.
Clinical & Logistical Metadata
| Test Name | MYD88 Gene Sequencing (Next-Generation Sequencing) for Recurrent Pyogenic Bacterial Infections Due to MYD88 Deficiency |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (3โ5 mL in EDTA tube), extracted genomic DNA, or dried blood spot on FTA card. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM โ 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) โ full gene coding regions and splice junctions with 99.9% diagnostic sensitivity |
| ICD-10-CM Code | D84.9 (Primary immunodeficiency, unspecified), D84.8 (Other specified immunodeficiencies) |
| LOINC Code | 21636-6 (DNA sequencing) |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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