Test Price
2,800 AED✅ Home Collection Available
MT‑CYB Gene Mitochondrial Encephalomyopathy Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
This next‑generation sequencing (NGS) test examines the entire coding region of the mitochondrial MT‑CYB gene to identify pathogenic variants linked to mitochondrial encephalomyopathy. It is the most comprehensive genetic assay for confirming complex III deficiency and guiding neurological management.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-accredited NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM–11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance with result interpretation.
- Insurance: Direct Billing Verification via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
This NGS assay sequences the complete open reading frame of the mitochondrial MT‑CYB gene, detecting single nucleotide variants, small insertions/deletions, and copy number alterations. Variants are classified per ACMG guidelines and correlated with clinical phenotypes of mitochondrial encephalomyopathy (Complex III deficiency).
| Attribute | This Test (DHA‑Licensed) | Standard Alternatives |
|---|---|---|
| Analytical Sensitivity | ≥99.9% for variants >5% heteroplasmy | Sanger sequencing (limited to common mutations) |
| Methodology | NGS with ACMG variant interpretation | Targeted mutation panels / enzyme assays |
| Turnaround Time | 3–4 weeks, with expedited option available | 5–8 weeks, no cold‑chain guarantee |
Physician Insight & Safety Protocols
“Mitochondrial encephalomyopathy presents with variable neurological symptoms that can be challenging to diagnose. This NGS test for the MT‑CYB gene provides a definitive molecular diagnosis when clinical and biochemical findings suggest Complex III deficiency. However, genetic results must always be interpreted in the context of the full clinical picture, and no therapeutic changes should be made without specialist supervision.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
⚠️ Important: Do Not Alter Medications Without Guidance
Abrupt withdrawal of certain medications (e.g., antiepileptics, metabolic supplements) may trigger a mitochondrial crisis. Always consult your neurologist or geneticist before modifying any prescription.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent (for minors, legal guardian must sign per Federal Decree‑Law No. 4 of 2016).
- Exclusion: Acute severe illness requiring immediate resuscitation (postpone collection until stable).
- ER Red Flags: Sudden loss of vision, new‑onset seizures, stroke‑like episodes, severe lactic acidosis, or acute neurological deterioration.
- ER Red Flags: Unexplained hypoglycaemia, hypothermia, or rapid cognitive decline – proceed to nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What is the MT‑CYB gene and why is it tested in mitochondrial encephalomyopathy?
The MT‑CYB gene encodes a critical subunit of mitochondrial Complex III. Pathogenic mutations impair cellular energy production, leading to encephalomyopathy. This NGS test identifies both known and novel variants across the entire coding region, enabling a definitive molecular diagnosis. It is recommended for patients with unexplained neurological decline, muscle weakness, or a family history suggestive of mitochondrial disease.
2. How is the NGS test performed and what sample is required?
We use next‑generation sequencing on a blood or extracted DNA sample to detect single nucleotide variants and small indels in MT‑CYB. Accepted specimens include 3–5 mL whole blood in EDTA, extracted genomic DNA, or a dried blood spot on an FTA card. All samples are transported at 2–8 °C via our ISO‑certified cold chain. Results are available in 3–4 weeks.
3. When should I consult a doctor after receiving the result?
A positive MT‑CYB result requires immediate neurological and genetic counselling to plan clinical management and family screening. Even a negative result may still warrant further mitochondrial testing if symptoms persist; always review findings with your specialist. Our post‑test telephonic guidance helps you understand implications and next steps.
UAE Regulatory & Data Privacy Adherence
This service complies with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensures secure handling of your genetic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governs digital health records and telemedicine.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – safeguards patient consent and clinical safety.
All results are delivered via encrypted channels. Specimens are processed in DHA‑licensed facilities under strict ISO 15189 quality standards.
Clinical & Logistical Metadata
| Test Name | MT‑CYB Gene Mitochondrial Encephalomyopathy Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (Expedited option available upon request) |
| Sample Type / Matrix | Whole Blood (EDTA) or Extracted Genomic DNA VIP Mobile Phlebotomy & Cold-Chain Home Collection available daily 8 AM–11 PM |
| Methodology Used | Next‑Generation Sequencing (NGS) – Full gene coding region coverage |
| ICD‑10‑CM Code | E88.40 (Mitochondrial metabolism disorder, unspecified) |
| LOINC Code | 101357-6 (Mitochondrial DNA full sequencing) |
| DHA Facility License & Address | License No. 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians