Test Price
2,800 AED✅ Home Collection Available
MT-TK Gene Analysis (MERRF Syndrome) – Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين MT-TK (متلازمة ميرف) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
الملخص التنفيذي
- ضمان الدقة: حساسية تشخيصية تصل إلى 99.9% عبر معالجة معتمدة وفق معيار ISO 9001:2015.
- الخدمات اللوجستية المتميزة: جمع عينات منزلية بمواصفات المستشفى عبر خدمة سلسلة التبريد المعتمدة ISO وفصادة متنقلة لكبار الشخصيات.
- الإرشاد السريري: استشارة هاتفية بعد الفحص لتفسير النتائج سريريًا من قبل فريق طبي معتمد.
- التغطية التأمينية: التحقق المباشر من تغطية التأمين عبر واتساب على الرقم +971 54 548 8731.
Clinical & Genetic Overview
This advanced Next‑Generation Sequencing (NGS) test screens the entire MT‑TK mitochondrial gene for pathogenic variants linked to Myoclonic Epilepsy with Ragged Red Fibers (MERRF) syndrome, a multi‑system disorder. The assay provides definitive molecular confirmation when clinical findings are suggestive, and supports family risk assessment and pregnancy planning.
| Feature | Our Test | Closest Alternative (mtDNA hotspot panel) |
|---|---|---|
| Precision | Full gene sequencing + copy number analysis | Limited to common point mutations (m.8344A>G only) |
| Methodology | NGS with Sanger confirmation & bioinformatic pipeline (2026 LC‑MS/MS validated) | Allele‑specific PCR or single‑site sequencing |
| Speed (TAT) | 3 to 4 weeks from sample receipt | 2 to 3 weeks (may miss rare variants) |
Physician Insight & Safety Protocol
“This test is a critical tool in the diagnostic odyssey for mitochondrial disease, but a negative result does not rule out MERRF, as heteroplasmy levels can vary across tissues. Clinical correlation with neuromuscular and metabolic findings remains paramount, and results should be interpreted within a multidisciplinary setting.”
— Dr. Prabhakar Reddy, DHA Licensed (License No. 61713011)
⚠️ Medication Safety Advisory
Do not discontinue any prescribed medication, anti‑epileptics, or supplements without explicit instruction from your treating physician. Premature changes may provoke severe decompensation in mitochondrial disorders.
Exclusion Criteria & Emergency Red Flags
- Known hypersensitivity to phlebotomy materials or anticoagulants.
- Acute metabolic crisis, status epilepticus, or stroke‑like episode – seek emergency care first.
- Severe coagulopathy or platelet count <20×10⁹/L (relative contraindication).
- Patients under 18 years must have legal guardian consent per UAE CDS Law 2026.
Patient FAQ & Clinical Guidance
What conditions does this MT‑TK gene test specifically diagnose?
A clinical‑grade NGS test that sequences the entire MT‑TK gene to detect disease‑causing variants associated with MERRF syndrome. The primary condition is MERRF (Myoclonic Epilepsy with Ragged Red Fibers), a progressive mitochondrial disorder causing myoclonus, epilepsy, ataxia, and muscle weakness. The test can also identify overlapping phenotypes such as MELAS or Leigh‑like presentations when MT‑TK mutations are found.
How should I prepare before the blood draw or FTA card collection?
Inform your physician and the lab about all current medications and supplements before sample collection to avoid interference. A 30‑minute genetic counselling session is required to draw a detailed three‑generation pedigree chart of family members affected by MERRF or unexplained myoclonic epilepsy. No fasting is necessary, and the home phlebotomist will verify your identity and clinical history.
ما الفرق بين اختبار NGS الكامل لجين MT‑TK واختبار لوحة الحمض النووي الميتوكوندري المحدود؟
يُحلّل اختبارنا كامل تسلسل جين MT‑TK باستخدام الجيل التالي من التسلسل، مما يكشف عن الطفرات النادرة والتغيرات في عدد النسخ. بينما تقتصر اللوحات التقليدية على اكتشاف الطفرة الشائعة m.8344A>G فقط، مما قد يفوّت تشخيص المتلازمات غير النمطية. نضمن بذلك تشخيصًا دقيقًا بنسبة 99.9% وفق معايير هيئة الصحة بدبي لعام 2026.
Pre‑ Requirements
A clinical history of the patient undergoing MT‑TK gene analysis for MERRF syndrome is mandatory. A dedicated genetic counselling session to construct a pedigree chart documenting affected family members with MT‑TK‑related MERRF syndrome must precede sample collection. Avoid any blood thinners unless medically indicated; the laboratory accepts whole blood, extracted DNA, or a single drop of blood on an FTA card.
Accreditation:
ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | DHA Facility License: 9834453
Compliant with Federal Decree‑Law No. 41 of 2024 (Art. 87) & UAE PDPL 2026
Support:
📞 +971 54 548 8731
WhatsApp for immediate booking & insurance verification
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