Test Price
4,000 AED✅ Home Collection Available
MPZ Full Length Gene Sequence Analysis (Charcot‑Marie‑Tooth Disease) – 4000 AED – DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (ISO 9001:2015, Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This single‑gene Sanger sequencing test decodes the entire MPZ (myelin protein zero) gene with nucleotide‑level resolution, pinpointing pathogenic variants responsible for Charcot‑Marie‑Tooth disease type 1B – the most common inherited peripheral neuropathy. The bidirectional Sanger method offers gold‑standard accuracy for all coding exons and splice‑site junctions.
| Feature | Our Test (Sanger Sequencing) | Closest Alternative (NGS Panel) |
|---|---|---|
| Precision | Gold‑standard single‑base accuracy; reads every exon & splice site | High but may miss deep intronic or low‑coverage regions |
| Method | Sanger Sequencing (bidirectional) | Next‑Generation Sequencing (multigene panel) |
| Turnaround Time | 3‑4 weeks (express option available) | 4‑6 weeks (often with secondary confirmatory step) |
| Clinical Utility | Definitive diagnosis of CMT1B; variant of uncertain significance clarified | Broad screening; incidental findings may complicate interpretation |
Physician Insight & Safety Protocols
“As a DHA‑licensed consultant medical geneticist, I emphasize that MPZ full‑length sequencing provides a definitive molecular diagnosis for Charcot‑Marie‑Tooth disease type 1B. However, results must be interpreted alongside clinical history, nerve conduction studies, and family pedigree. A negative result does not exclude other CMT subtypes; comprehensive neurological and genetic counseling is essential for all patients.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Management
DO NOT discontinue any prescribed medication (e.g., analgesics, anticonvulsants for neuropathic pain, physiotherapy regimens) without consulting your physician. Genetic test results do not replace ongoing symptomatic management.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Active systemic infection (fever >38.5°C)
- Severe coagulopathy or current anticoagulant therapy that cannot be temporarily held (for invasive samples)
- Uncontrolled psychiatric condition impairing informed consent
- Pregnancy‑related contraindications for amniocentesis/CVS (evaluated by fetal medicine specialist)
Seek Emergency Care If
- Sudden, rapidly progressive muscle weakness or paralysis
- Respiratory difficulty or choking sensation
- Loss of bladder or bowel control
- Severe, unrelenting neuropathic pain unresponsive to usual medication
Patient FAQ & Clinical Guidance
1. What exactly does MPZ full‑length gene sequencing detect?
This test detects single‑nucleotide variants, small insertions/deletions, and splice‑site mutations across the entire MPZ gene, providing a definitive molecular diagnosis of Charcot‑Marie‑Tooth disease type 1B with near‑100% analytical sensitivity for coding regions.
2. How should I prepare before sample collection?
No fasting or special preparation is required for peripheral blood. For amniotic fluid or chorionic villus samples, a dedicated fetal medicine consultation will provide you with precise pre‑procedural instructions and consent paperwork.
3. Can I use my health insurance for this test?
Many UAE insurers cover genetic testing when medically indicated. Our team will verify your policy directly via WhatsApp +971 54 548 8731 and provide a pre‑authorization estimate before you proceed, so you face no unexpected costs.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted, access‑controlled, and handled in accordance with ISO 27001 standards. Written informed consent is obtained for genetic testing of minors as per UAE regulations.
Clinical & Logistical Metadata
| Test Name | MPZ Full Length Gene Sequence Analysis (Charcot‑Marie‑Tooth Disease) |
| Price (AED) | 4,000 |
| Turnaround Time | 3‑4 weeks |
| Sample Type / Matrix | Peripheral Blood |
| Methodology Used | Sanger Sequencing (Bidirectional) |
| ICD‑10‑CM Code | G60.0 |
| LOINC Code | 81319-6 |
| DHA Facility License & Laboratory Address | DHA License: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians