Test Price
2,800 AED✅ Home Collection Available
MLC1 Gene Megalencephalic Leukoencephalopathy with Subcortical Cysts Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance with result interpretation support from a DHA-licensed genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MLC1 gene test utilises Next-Generation Sequencing (NGS) to detect pathogenic variants associated with Megalencephalic Leukoencephalopathy with Subcortical Cysts (MLC), a rare autosomal recessive neurological disorder characterised by macrocephaly, motor decline, and seizures. This genetic test provides definitive molecular diagnosis to guide early intervention, genetic counselling, and informed family planning for affected individuals and their families in the UAE.
| Feature | Our Test (NGS – UAE) | Closest Alternative (Sanger Panel) |
|---|---|---|
| Methodology | Full gene NGS (MLC1, all exons) | Limited Sanger sequencing of hotspot regions |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Sample Types | Whole Blood, Extracted DNA, FTA Card | Whole Blood only |
| Diagnostic Sensitivity | >99% | ~85% (misses deep intronic variants) |
| Regulatory Compliance | DHA Licensed, ISO 9001:2015, UAE PDPL | Basic lab accreditation |
Physician Insight & Safety Protocols
“Understanding that a child may have a rare leukodystrophy is profoundly challenging for any family. This MLC1 gene test offers a path to diagnostic clarity, yet the result must always be interpreted within a comprehensive neurological and genetic counselling framework. A positive finding confirms the diagnosis and enables targeted clinical management, whereas a negative result does not exclude other leukodystrophies and should never lead to cessation of ongoing medical care.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Medication Advisory
Do not discontinue any prescribed anticonvulsant or other medication without explicit guidance from the treating neurologist. This genetic test provides diagnostic information only and does not replace ongoing clinical management or therapeutic decision-making.
Exclusion Criteria & Emergency Red Flags
- Exclusion: This test is not intended for asymptomatic population screening; a referral from a neurologist or clinical geneticist based on clinical suspicion of MLC is mandatory.
- Not for minors without guardian consent in accordance with UAE Federal Law No. 2 of 2019 concerning health data protection.
- Emergency red flags: Acute neurological deterioration, status epilepticus, loss of consciousness, or respiratory distress require immediate emergency medical attention and must not await genetic test results.
- Sample integrity: FTA card samples must be collected and stored according to the cold-chain protocol; degraded DNA may delay results or require re-collection.
Patient FAQ & Clinical Guidance
1. What is the purpose of the MLC1 gene test?
The test identifies disease-causing mutations in the MLC1 gene to confirm a clinical diagnosis of megalencephalic leukoencephalopathy with subcortical cysts, enabling targeted neurological management, genetic counselling, and family planning decisions.
2. How is the sample collected in the UAE?
A certified mobile phlebotomist visits your home between 8 AM and 11 PM to collect a venous blood sample under ISO-certified temperature-controlled cold-chain conditions. Alternatively, a finger-prick sample on an FTA card can be provided following sterile protocol instructions.
3. What do the results mean and who explains them?
A positive report confirms a biallelic pathogenic MLC1 variant establishing the MLC diagnosis. A negative result rules out MLC1-related disease but does not exclude other leukodystrophies. A DHA-licensed Consultant Medical Genetics professional provides telephonic post-test counselling to interpret the findings and outline next steps.
UAE Regulatory & Data Privacy Adherence
Secure & Compliant Data Handling
All patient genetic data is processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information is encrypted, access-controlled, and used solely for diagnostic and counselling purposes.
Clinical & Logistical Metadata
| Test Name | MLC1 Gene Megalencephalic Leukoencephalopathy with Subcortical Cysts Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | E75.21 |
| LOINC Code | 94233-3 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians