Test Price
1,200 AED✅ Home Collection Available
Megalencephalic Leukoencephalopathy with Subcortical Cysts (MLC Gene Hotspot Mutation) Test in UAE | 1200 AED | 2026 DHA Guidelines
تحليل طفرة جين MLC المسببة لمرض ضمور المادة البيضاء الدماغي مع التكهفات تحت القشرية (مرض فان دير ناب) في الإمارات | 1200 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited molecular processing. Premium logistics: paid hospital-grade home collection 8 AM–11 PM with ISO-certified cold-chain transport. Telephonic post-test clinical guidance included. Direct insurance billing verification via WhatsApp +971 54 548 8731.
ملخص تنفيذي: دقة تصل إلى 99.9% عبر معالجة جزيئية معتمدة ISO 9001:2015. خدمة سحب الدم المنزلي المدفوعة بتقنية سلسلة التبريد المعتمدة. استشارة طبية هاتفية بعد النتيجة. التحقق المباشر من التغطية التأمينية عبر واتساب +971 54 548 8731.
Test Overview
This genetic test detects hotspot mutations in the MLC1 gene associated with megalencephalic leukoencephalopathy with subcortical cysts (Van der Knaap disease) using PCR and bidirectional Sanger sequencing. It aids neurologists, paediatric neurologists and clinical geneticists in confirming the diagnosis in symptomatic children and adults, while supporting familial genetic counselling.
Our Test vs. Alternative Options
| Feature | Our Test (UAE Leading Lab) | Closest Alternative |
|---|---|---|
| Precision | MLC1 hotspot mutation analysis (PCR + bidirectional sequencing) | Whole gene sequencing (broader, slower) |
| Method | ISO-certified PCR & Sanger sequencing | NGS panel (may include irrelevant genes) |
| Turnaround Time | 5 working days (Mon sample by 11am, report Fri) | 10–14 days |
| Price | AED 1200 | AED 1800+ |
Physician Insight & Safety Protocols
“As a clinician, I emphasise that this genetic test provides confirmation but must be correlated with MRI findings and clinical symptoms. Do not interpret a negative result as an exclusion of other leukoencephalopathies; genetic counselling remains crucial. Always involve a neurologist before making treatment decisions.” – Dr. Prabhakar Reddy (DHA License: 61713011)
Medication Warning
Do not discontinue any prescribed medication or alter treatment without consulting your neurologist or primary physician. This test is diagnostic, not therapeutic.
Exclusion Criteria & ER Red Flags:
- Exclusion: Haemolysed or clotted sample, incorrect tube type – recollect required.
- ER Red Flags: If the patient experiences acute seizures, loss of consciousness, or sudden vision/speech changes, seek emergency care immediately – do not wait for test results.
- Not to be performed on asymptomatic minors without court order or parental consent, as per UAE CDS Law 2026.
UAE Regulatory & E-E-A-T Compliance
This test complies with Federal Decree-Law No. 41 of 2024 (Article 87) on genetic testing, UAE PDPL for genetic data privacy, and CDS Law 2026 for testing of minors. Our facility operates under DHA license 9834453, ISO 9001:2015 certified (INT/EGQ/2509DA/3139), and all specimens are processed in a UAE‑sovereign medical laboratory.
Patient FAQs & Clinical Guidance
1. What does this test detect and who should consider it?
Snippet: This identifies hotspot mutations in the MLC1 gene causing Van der Knaap disease, primarily recommended for children with macrocephaly, motor delays, or MRI evidence of subcortical cysts.
١. ماذا يكشف هذا التحليل ومن يجب أن يخضع له؟
يكشف هذا التحليل عن طفرات جين MLC1 المسببة لمرض فان دير ناب، ويُوصى به للأطفال الذين يعانون من تضخم الرأس أو تأخر حركي أو وجود تكهفات تحت القشرية في التصوير بالرنين المغناطيسي.
2. How is the sample collected and what preparation is needed?
Snippet: A simple venous blood draw (4 mL in lavender top EDTA tube) is collected, refrigerated immediately, and must not be frozen; no fasting required.
٢. كيف يتم سحب العينة وما التحضيرات اللازمة؟
يتم سحب عينة دم وريدي بسيطة (4 مل في أنبوب إيدتا بنفسجي) تُحفظ مبردة ولا تُجمد أبداً، دون حاجة للصيام.
3. When will I receive results and how are they interpreted?
Snippet: Reports are delivered within 5 working days (Friday if sample received by Monday 11am) with a telephonic consultation by a clinical expert to explain findings.
٣. متى ستصل النتائج وكيف يتم تفسيرها؟
تصدر النتائج خلال 5 أيام عمل (الجمعة إذا استُلمت العينة الاثنين قبل 11 صباحاً) مع استشارة هاتفية من خبير سريري لشرحها.
To schedule your home collection or verify insurance, WhatsApp +971 54 548 8731 (8 AM – 11 PM daily). A duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians