Test Price
2,800 AED✅ Home Collection Available
MEFV Gene Familial Mediterranean Fever (FMF) NGS Panel – Genetic Test in Dubai
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Result Interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced genetic test employs Next-Generation Sequencing (NGS) to perform comprehensive analysis of the MEFV gene, targeting all coding exons and conserved splice-site regions. It is the molecular gold standard for confirming a clinical diagnosis of Familial Mediterranean Fever (FMF), an autosomal recessive autoinflammatory disorder characterized by recurrent episodes of fever, peritonitis, pleuritis, and arthritis. The test also detects copy number variations (CNVs) and rare intronic variants that may escape conventional PCR-based panels.
| Feature | Our Test (NGS) | Closest Alternative (PCR Panel) |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity, full gene sequencing | ~85% limited to common mutations |
| Methodology | Illumina NGS with CNV detection | Allele-specific PCR / Sanger |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics, I confirm that comprehensive NGS sequencing of the MEFV gene is the definitive molecular approach for diagnosing Familial Mediterranean Fever. While this test provides a high-confidence genetic result, it must be interpreted alongside the patient's clinical presentation, family history, and inflammatory markers. Genetic counseling is strongly recommended for all patients and their at-risk relatives."
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do Not Alter Prescribed Therapy Without Medical Consultation
Do not modify or discontinue any prescribed treatment, particularly colchicine therapy, without consulting your treating physician. Abrupt medication changes can precipitate severe inflammatory flares and complications.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Testing is deferred for individuals presenting with acute febrile illness at the time of collection; reschedule when clinically stable.
- Minors: Written consent from a legal guardian is mandatory in compliance with UAE pediatric care regulations.
- Emergency Red Flags: Seek immediate medical attention if you experience severe abdominal pain, chest pain, persistent high fever exceeding 40°C, or signs of acute peritonitis before or after testing.
Patient FAQ & Clinical Guidance
1. What is the MEFV gene test and what clinical purpose does it serve?
The MEFV gene test uses next-generation sequencing to detect mutations causing Familial Mediterranean Fever, an inherited autoinflammatory disorder. It is the gold standard for confirming a diagnosis in symptomatic patients and for identifying carrier status in family members, enabling early intervention and targeted therapy.
2. How is the MEFV genetic test sample collected and processed?
A trained phlebotomist visits your home for a standard blood draw, or you may provide a DNA sample on an FTA card. The sample is transported in a monitored cold chain at 2–8°C to our ISO-certified laboratory. Results are delivered within 3 to 4 weeks.
3. What is the clinical significance of a positive MEFV mutation result?
A positive result confirms a diagnosis of Familial Mediterranean Fever and guides targeted treatment with colchicine to prevent acute attacks and long-term complications such as amyloidosis. It also enables predictive testing for at-risk relatives and informs family planning decisions.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic data is encrypted, access-restricted, and processed exclusively within secure UAE-based infrastructure.
Clinical & Logistical Metadata
| Test Name | MEFV Gene Familial Mediterranean Fever (FMF) NGS Panel |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or DNA Sample (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV Detection |
| ICD-10-CM Code | M04.1 |
| LOINC Code | 56762-6 |
| DHA Facility License & Laboratory Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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