Test Price
4,800 AED✅ Home Collection Available
MEFV Full Gene Sequencing in UAE | 4800 AED
Executive Summary & Core Metrics
Accuracy Guarantee
99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM.
Clinical Guidance
Telephonic Post‑Test Clinical Guidance by a DHA‑Licensed Physician explaining your results and next steps.
Insurance Support
Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
Genetic Test replaces outdated single‑exon screening with a complete gene‑wide analysis using Next Generation Sequencing (NGS), ensuring no mutation—whether classical or atypical—is missed. The test covers all coding exons and flanking intronic regions of the MEFV gene, providing definitive molecular diagnosis for Familial Mediterranean Fever.
| Feature | Our Test (NGS Full Gene) | Closest Alternative (Targeted PCR) |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity, covers all exons & regulatory regions | ~85% sensitivity, only common mutations (e.g., M694V) |
| Methodology | Next Generation Sequencing (NGS) – Gold Standard | PCR‑based fragment analysis, limited scope |
| Turnaround Time | 4‑6 weeks (comprehensive bioinformatics) | 2‑3 weeks (faster but incomplete) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“As a clinical geneticist, I emphasize that MEFV full gene sequencing provides the highest resolution for diagnosing Familial Mediterranean Fever. A positive result confirms the diagnosis and guides lifelong colchicine therapy, which significantly reduces the risk of amyloidosis. However, a negative result does not exclude all autoinflammatory syndromes—comprehensive clinical evaluation by a rheumatologist or geneticist remains essential for proper management.”
Medication Advisory
Do not discontinue prescribed medication (e.g., colchicine) without consulting your doctor. Abrupt cessation can trigger severe FMF attacks and accelerate amyloidosis progression. Always discuss test results with your treating physician before making any therapeutic changes.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Age under 18 without valid legal guardian consent. Recent blood transfusion (<3 weeks) may interfere with germline analysis.
- Exclusion: Acute severe infection or unstable medical condition that contraindicates venipuncture.
- ER Red Flag: If you experience high fever >39°C, severe chest or abdominal pain, or signs of anaphylaxis shortly after sample collection, seek emergency care immediately and inform staff of the phlebotomy procedure.
- ER Red Flag: Unexplained bleeding, rapid swelling at the puncture site, or neurological changes after collection—proceed to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is MEFV full gene sequencing and who should consider it?
MEFV full gene sequencing uses NGS to analyze the entire MEFV gene for mutations causing Familial Mediterranean Fever. It is recommended for patients with recurrent febrile episodes, serositis, or a family history of FMF, as well as for asymptomatic siblings of confirmed cases. This test provides a definitive genetic diagnosis that supports lifelong management with colchicine and reduces the risk of secondary amyloidosis.
2. How do I prepare for the test and what does the 4‑6 week turnaround mean?
No fasting is required, but you must bring a valid DHA‑approved doctor’s prescription and your Emirates ID. The 4‑6 week turnaround time reflects complete NGS library preparation, deep sequencing, and complex bioinformatic analysis to ensure every exon is evaluated. Results are delivered securely via our patient portal with an optional physician consultation included in the service.
3. Is the test covered by insurance and can children undergo it?
Many UAE insurers cover MEFV gene sequencing when accompanied by a rheumatologist’s or geneticist’s prescription and pre‑approval. Children can be tested with valid parental consent in compliance with UAE pediatric consent regulations; a pediatric phlebotomy specialist performs the gentle blood draw at home. Contact our insurance verification team via WhatsApp for a quick eligibility check.
4. What does a positive MEFV mutation result mean for treatment?
A pathogenic MEFV mutation confirms the diagnosis of Familial Mediterranean Fever and justifies initiation of colchicine therapy. Lifelong adherence to colchicine dramatically reduces attack frequency and prevents the development of amyloidosis, the most serious complication of untreated FMF. Your genetic counselor or rheumatologist will interpret the result alongside your clinical history and inflammatory markers to guide management.
UAE Regulatory & Data Privacy Adherence
This test and all associated data handling comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted and stored in Dubai-based servers with restricted access. ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) ensures continuous quality management.
Clinical & Logistical Metadata
| Test Name | MEFV Full Gene Sequencing (NGS) |
| Price (AED) | 4,800 AED |
| Turnaround Time | 4–6 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) |
| Methodology Used | Next Generation Sequencing (NGS) – Whole gene analysis |
| ICD-10-CM Code | E85.0 |
| LOINC Code | 81247-9 |
| DHA Facility License & Address | DNA Labs UAE – License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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