Test Price
2,800 AED✅ Home Collection Available
MCM4 Gene Immunodeficiency with Natural Killer Cell Deficiency Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Clinical Executive Summary
This advanced NGS test achieves 99.9% diagnostic sensitivity for mutations in the MCM4 gene linked to natural killer cell deficiency. Our DHA‑licensed VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection ensures sample stability, and a telephonic post‑test clinician consultation with a Consultant Medical Geneticist is included to clarify your genetic report. Insurance pre‑approval is supported via WhatsApp at +971 54 548 8731.
Core Metrics at a Glance
- Test Price: 2,800 AED (all‑inclusive, no hidden fees)
- Turnaround Time: 3 to 4 weeks from sample receipt
- Methodology: Next‑Generation Sequencing (NGS) – full gene coding region plus flanking intronic boundaries
- Sample Type: Peripheral whole blood (3–5 mL EDTA tube) or FTA card dried blood spot
- Certifications: ISO 15189 accredited laboratory; DHA Facility License No. 1143
Test Overview & Methodology
The MCM4 NGS panel decodes the full coding sequence of the MCM4 gene (plus at least 20 bp of flanking intronic regions), revealing pathogenic variants that impair natural killer cell development and function. Unlike broad immunodeficiency screens, this targeted test delivers unambiguous results directly actionable by clinical geneticists and immunologists, reducing diagnostic odyssey and guiding personalized prophylactic or therapeutic strategies.
| Feature | Our Test (NGS Full Gene Sequencing) | Standard Alternative (Targeted Sanger Sequencing) |
|---|---|---|
| Resolution | Detects single nucleotide variants, indels, and copy number changes across the entire MCM4 gene | Limited to a few known hotspots; misses deep intronic or large deletion/duplication variants |
| Diagnostic Sensitivity | 99.9% for known and novel pathogenic variants (verified by orthogonal confirmation) | Approximately 70–80% depending on population |
| Turnaround Time | 3 to 4 weeks from sample receipt | Often 6–8 weeks due to sequential exon amplification |
| Variant Spectrum | Full coding region, splice sites, and CNVs | Only pre‑selected exons or hotspots |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“Ordering this test often comes at a deeply emotional point for families searching for answers. Our NGS approach reduces ambiguity, but a positive or negative result must be woven into the complete clinical picture—infectious history, cellular counts, and family pedigree. I always emphasize that a genetic report is a compass, not a destination, and multidisciplinary follow‑up remains non‑negotiable.”
Important Medication Advisory
⚠️ Do Not Discontinue Prescribed Medication
Do not stop infection prophylaxis, immunomodulatory therapy, or any other prescribed treatment without consulting your specialist. A positive MCM4 variant does not replace the immediate need for clinical management decided by your physician.
Safety & Exclusion Criteria
- Acute febrile illness or active uncontrolled infection may interfere with immune cell profiling; delay testing until clinical stabilization.
- Recent blood transfusion or hematopoietic stem cell transplant (within 4 weeks) – discuss with lab before sampling.
- Individuals under 18 require explicit parental/legal guardian consent per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability; written authorization is mandatory.
- Red Flags: Sudden onset of severe opportunistic infections, persistent lymphopenia, or unexplained splenomegaly — seek immediate emergency care.
Patient FAQ & Clinical Guidance
1. What exactly does the MCM4 gene test reveal?
This NGS test identifies pathogenic DNA variants in the MCM4 gene that disrupt natural killer cell development and cause primary immunodeficiency with recurrent viral infections and lymphoproliferation. The result includes a clear classification (pathogenic, likely pathogenic, VUS, likely benign, benign) with ACMG/AMP evidence grading.
2. Can I collect the sample at home, and how stable is the DNA?
Yes, our DHA‑licensed VIP Mobile Phlebotomy team performs hospital‑grade home collection daily from 8 AM to 11 PM. Whole blood (3–5 mL EDTA tube) is transported in ISO‑certified temperature‑controlled cold‑chain packaging, preserving high‑molecular‑weight DNA for optimal NGS performance. FTA card dried blood spots are also accepted for mailing.
3. Will my insurance cover this genetic test?
Direct billing verification with major UAE insurers is arranged before collection. Contact our team on WhatsApp at +971 54 548 8731 with your Emirates ID and insurer details for instant pre‑approval confirmation and coverage assessment.
4. How long does it take to get results?
The standard turnaround time is 3 to 4 weeks from the date of sample receipt at our laboratory. A detailed clinical report is delivered electronically via secure patient portal and a telephonic consultation is scheduled with our Consultant Medical Geneticist to review findings.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the highest standards of data protection and healthcare regulatory compliance in the United Arab Emirates:
- Data Privacy: Full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – all genetic data is encrypted, access‑controlled, and never shared with third parties without explicit patient consent.
- Health Information Governance: Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring secure electronic health record handling and telemedicine protocols.
- Clinical Safety & Consent: All testing procedures follow the standards set by Federal Decree-Law No. 4 of 2016 on Medical Liability, with mandatory informed consent obtained before sample collection.
- Laboratory Accreditation: DHA Facility License No. 1143, ISO 15189 accredited, with rigorous internal and external quality control programs.
Clinical & Logistical Metadata
| Test Name | MCM4 Gene Immunodeficiency with Natural Killer Cell Deficiency Genetic Test (NGS Full Gene Sequencing) |
| Price (AED) | 2,800 AED (includes phlebotomy, analysis, clinical report, and post‑test consultation) |
| Turnaround Time | 3 to 4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL EDTA tube) or FTA card dried blood spot |
| Methodology Used | Next‑Generation Sequencing (NGS) – full coding region, splice sites, and flanking intronic sequences with CNV detection |
| ICD-10-CM Code | D84.9 (Primary immunodeficiency, unspecified), Z15.09 (Genetic susceptibility to other disease) |
| LOINC Code | 94222-7 (MCM4 gene targeted mutation analysis in Blood or Tissue by NGS) |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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