Test Price
2,800 AED✅ Home Collection Available
MAP2K2 Gene Sequencing Test for Cardiofaciocutaneous Syndrome Type 4 (CFC4) in Dubai | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity via Next-Generation Sequencing on the Illumina NovaSeq platform, processed in an ISO 9001:2015-certified laboratory.
Premium Logistics: Hospital-grade home collection with ISO-validated cold-chain transport; VIP Mobile Phlebotomy service available daily from 8 AM to 11 PM.
Clinical Guidance: Telephonic post-test consultation with a DHA-licensed consultant medical geneticist for result interpretation.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The MAP2K2 gene sequencing test employs targeted Next-Generation Sequencing (NGS) at greater than 200x read depth to detect pathogenic variants causing Cardiofaciocutaneous Syndrome Type 4 (CFC4). This rare autosomal dominant RASopathy is characterized by congenital heart defects, distinctive facial features, and ectodermal abnormalities. Early molecular confirmation enables enrollment in specialized Rasopathy clinics and informed family planning across the UAE.
| Feature | Our MAP2K2 NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Methodology | Targeted NGS with >200x depth for MAP2K2 | WES with average 100x depth, lower resolution for single gene |
| Diagnostic Sensitivity | 99.9% for known pathogenic variants | ~95% ; may miss deep intronic or low-level mosaicism |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Cost (AED) | 2,800 | 4,500–6,000 |
| Variant Interpretation | Focused ACMG/AMP classification with CFC4-specific database | Broad analysis, may generate incidental findings |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I emphasize that MAP2K2 sequencing results must always be interpreted alongside a full clinical phenotype — including echocardiography, electrocardiogram, and dysmorphology assessment. A positive variant confirms the diagnosis of CFC4 but does not replace the necessity of multidisciplinary follow-up with paediatric cardiology and dermatology. Families are encouraged to pursue genetic counselling for recurrence risk assessment and lifelong surveillance planning.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice for Medication and Therapy Continuity
Important Clinical Advisory
Do not discontinue any prescribed cardiac, dermatologic, or developmental therapy without consulting your treating physician. Genetic results inform diagnosis and long-term management; they do not alter ongoing emergency or stabilizing treatments.
Exclusion Criteria and Emergency Red Flags
Contraindications and Urgent Warnings
- Exclusion: Active febrile illness, severe haemophilia, or inability to obtain informed paediatric consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Emergency Red Flags post-collection: New-onset chest pain, palpitations, syncope, or signs of anaphylaxis — seek immediate emergency care.
- Data Privacy: All genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Patient FAQ & Clinical Guidance
1. What does the MAP2K2 gene test detect, and who should consider it in the UAE?
The test identifies pathogenic MAP2K2 mutations responsible for Cardiofaciocutaneous syndrome type 4, confirming the diagnosis in patients with congenital heart defects and characteristic facial features. In the UAE, it is recommended by cardiologists and medical geneticists for any child or adult presenting with pulmonic stenosis, hypertrophic cardiomyopathy, or a family history of CFC syndrome. Early molecular confirmation enables enrolment in specialized Rasopathy clinics and informed family planning.
2. How is the sample collected, and when will I receive the results?
A certified phlebotomist performs a simple blood draw or finger-prick onto an FTA card during a home visit, and the full genetic report is ready in 3 to 4 weeks. Our mobile nurse arrives within 60 minutes of booking in Dubai, Sharjah, and Abu Dhabi, carrying ISO-validated cold-chain transport containers. DNA is extracted and sequenced using Illumina NGS technology, with every variant classified according to ACMG/AMP guidelines. You will receive a secure electronic report and a tele-consultation slot automatically.
3. Does health insurance in the UAE cover the MAP2K2 gene sequencing test?
Most UAE health insurance plans cover MAP2K2 sequencing when ordered by a cardiologist or geneticist for a clinical indication. Our billing team verifies coverage directly with your insurer via WhatsApp at +971 54 548 8731 within one hour. Self-pay options with flexible instalments are also available.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection: DNA Labs UAE operates under DHA Facility License Number 1143 and is ISO 9001:2015 certified. All genetic data processing complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Genetic counselling is provided exclusively by DHA-licensed professionals.
Clinical & Logistical Metadata
| Test Name | MAP2K2 Gene Sequencing Test for Cardiofaciocutaneous Syndrome Type 4 (CFC4) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood or FTA card finger-prick; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) on Illumina NovaSeq platform, >200x depth |
| ICD-10-CM Code | Q87.89 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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