Test Price
2,800 AED✅ Home Collection Available
LYST Gene Chediak‑Higashi Syndrome Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity across the entire LYST coding region via ISO‑certified NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily 8 AM–11 PM.
- Clinical Guidance: Post‑test tele‑counselling by a consultant medical geneticist to interpret results and plan management.
- Insurance: Direct coverage verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This test employs Next‑Generation Sequencing (NGS) to analyse the entire coding region of the LYST gene, diagnosing Chediak‑Higashi syndrome—a rare autosomal recessive disorder characterised by oculocutaneous albinism, recurrent pyogenic infections, and a lifelong predisposition to haemophagocytic lymphohistiocytosis and lymphoma. The assay covers single nucleotide variants, small insertions/deletions, and copy number changes with >99.9% sensitivity.
| Feature | Our Test (NGS – LYST Full Gene) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Technology | Next‑Generation Sequencing (NGS) | Sanger sequencing |
| Analytical Sensitivity | > 99.9% for SNVs, indels, and CNVs | Limited to known hot‑spot variants; may miss large rearrangements |
| Turnaround Time | 3 to 4 weeks | 4 to 6 weeks |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I see every Chediak‑Higashi evaluation as an opportunity to offer definitive molecular answers. This NGS test provides comprehensive coverage of the LYST gene, but interpreting results always requires correlation with the full clinical phenotype, family history, and parental carrier studies. I strongly encourage patients to remain under specialist supervision and to never alter prescribed treatments without medical consultation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Medication Alert
Do not discontinue any prescribed medication without consulting your doctor.
Exclusion Criteria
- Acute febrile illness or severe, uncontrolled infection.
- Inability to provide a venous blood sample, extracted DNA, or dried blood spot.
- Individuals lacking clinical or family‑history indications for Chediak‑Higashi testing.
Emergency Red Flags
- Sudden high fever (>38.5 °C) with chills or hypotension.
- Unexplained bruising, mucosal bleeding, or petechiae.
- Rapidly enlarging lymph nodes, night sweats, and unintentional weight loss (lymphoma warning signs).
- Any signs of neurological deterioration require immediate hospital evaluation; this genetic test does not substitute for urgent clinical assessment.
Patient FAQ & Clinical Guidance
1. What is the LYST gene test, and why is it performed?
This NGS test accurately diagnoses Chediak‑Higashi syndrome by detecting pathogenic variants in the LYST gene. It identifies disease‑causing mutations across the entire coding sequence, enabling confirmation of the clinical diagnosis, carrier testing for family members, and informed genetic counselling. A positive result guides lifelong surveillance for infections, bleeding tendencies, and lymphoreticular malignancies.
2. Which specialists manage Chediak‑Higashi syndrome, and how does this test help?
The test output is critical for dermatologists, oncologists, and clinical geneticists who manage the lifelong multisystem care of Chediak‑Higashi syndrome. Dermatologists address recurrent cutaneous infections and pigment dilution; oncologists screen for haemophagocytic lymphohistiocytosis and lymphoma; clinical geneticists provide family counselling and prenatal/preimplantation genetic diagnosis. The NGS result harmonises this multidisciplinary approach.
3. What sample types are accepted, and is a genetic counselling session required?
We accept whole blood, extracted DNA, or a single drop of blood on an FTA card for analysis. Prior to testing, a formal genetic counselling session is mandatory to draw a detailed pedigree of family members affected by LYST‑related disease. This ensures appropriate interpretation of variants and informed consent. Our team can schedule a remote tele‑counselling appointment at your convenience.
4. How long does it take to get results, and what do they include?
Turnaround time is 3 to 4 weeks from sample receipt. The report lists all detected variants in the LYST coding region, their classification according to ACMG guidelines, and a clinical interpretation tailored to the patient's phenotype. A post‑test consultation with the referring physician or a genetic counsellor is recommended to discuss implications.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License No. 1143 and adheres to all applicable UAE federal laws governing health data and personal privacy. Patient data handling complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures, including specimen collection and patient consent, follow the standards set by Federal Decree‑Law No. 4 of 2016 on Medical Liability. Your genetic information is encrypted, access‑controlled, and never shared without explicit consent.
Clinical & Logistical Metadata
| Test Name | LYST Gene Chediak‑Higashi Syndrome Genetic Test (NGS Full Gene Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or Dried Blood Spot (FTA card) |
| Methodology Used | Next‑Generation Sequencing (NGS) – Full Gene Coding Region & Splice Sites |
| ICD-10-CM Code | E70.330 (Chediak‑Higashi syndrome) |
| LOINC Code | 94042-4 (LYST gene full sequencing) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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