Test Price
2,800 AED✅ Home Collection Available
LRRC8A Gene Agammaglobulinemia Type 5 (Autosomal Recessive) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين LRRC8A لكشف غاما غلوبولين الدم من النوع الخامس الجسدي المتنحي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited NGS Sequencing.
- ضمان الدقة: حساسية تشخيصية 99.9% باستخدام التسلسل الجيني المعتمد دولياً من الجيل التالي (NGS).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain & VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance Support: Direct Billing Verification via WhatsApp +971 54 548 8731.
Overview
This advanced genetic test sequences the entire LRRC8A gene using Next Generation Sequencing (NGS) to detect causative mutations for autosomal recessive agammaglobulinemia type 5—a severe primary immunodeficiency characterized by near-absent B cells and extremely low antibody levels. (يكشف هذا التحليل الطفرات المسببة لنقص غاما غلوبولين الدم الوراثي المتنحي من النوع الخامس بدقة فائقة.) Ideal for confirmatory diagnosis, carrier screening, and family planning.
| Feature | Our Test (UAE Premium) | Closest Alternative |
|---|---|---|
| Methodology | Full Gene NGS (High Coverage) | Single-gene Sanger or Targeted Panel |
| Clinical Sensitivity | >99% for point mutations/indels | Variable, may miss deep intronic variants |
| Turnaround Time | 3–4 Weeks (Expedited Available) | 4–8 Weeks |
| Included Support | Genetic Counselling + Tele-Guidance | Report Only |
Physician Insight & Safety Protocol
“A positive LRRC8A result confirms the diagnosis but must be interpreted alongside immunoglobulin levels and clinical history. Even with a clear genetic finding, treatment decisions require a multidisciplinary team approach. Your care journey does not end with this report—it’s a starting point for precision management.”
— Dr. PRABHAKAR REDDY, DHA Licensed Consultant (DHA-61713011)
Medication Warning
Do not discontinue any prescribed medication or immunoglobulin therapy without consulting your doctor. Genetic results alone do not replace clinical monitoring.
Safety Exclusion Criteria & ER Red Flags
- Exclusion: Active severe infection requiring hospitalization; recent blood transfusion (within 4 weeks) may delay testing.
- ER Red Flags: If the individual develops sudden high fever, respiratory distress, or signs of sepsis, seek emergency care immediately—do not wait for genetic results.
- All patients must undergo a pre-test genetic counselling session to document a three-generation pedigree.
Pre-test Requirements
A detailed clinical history and a formal genetic counselling session are mandatory to draw a pedigree chart of family members affected by or carriers of the LRRC8A gene mutation. No food or medication restrictions are necessary for blood/DNA collection, but please inform the phlebotomist of any anticoagulant use.
Patient FAQ & Clinical Guidance
Q: What is the LRRC8A gene test for? / ما هو فحص جين LRRC8A؟
This test detects LRRC8A mutations causing autosomal recessive agammaglobulinemia type 5, a severe immune deficiency. Agammaglobulinemia type 5 leads to almost no mature B cells and profound hypogammaglobulinemia, leaving patients susceptible to recurrent bacterial infections from early infancy. The test confirms the diagnosis and guides lifelong immunoglobulin replacement therapy and genetic counselling.
يكشف هذا الاختبار الطفرات في جين LRRC8A المسببة لنقص غاما غلوبولين الدم الوراثي المتنحي من النوع الخامس، وهو عوز مناعي شديد يؤدي إلى غياب شبه كامل للخلايا البائية. يساعد في تأكيد التشخيص وتوجيه العلاج التعويضي بالغلوبولين المناعي والاستشارة الوراثية.
Q: How is the performed? / كيف يتم إجراء الاختبار؟
We analyze your blood, extracted DNA, or FTA card sample using NGS for LRRC8A mutations. A small blood draw, previously extracted DNA, or a single drop of blood on an FTA card is accepted. Our laboratory extracts DNA and sequences the entire LRRC8A gene with high depth, ensuring detection of even low-level variants. Results are ready in 3–4 weeks.
يتم تحليل عينة الدم أو الحمض النووي المستخلص أو بطاقة FTA باستخدام تقنية التسلسل الجيني من الجيل التالي لفحص الطفرات في جين LRRC8A. تستغرق النتيجة ٣ إلى ٤ أسابيع.
Q: What are the benefits of genetic testing and counselling? / ما فوائد الفحص الجيني والاستشارة الوراثية؟
Genetic testing enables early diagnosis and treatment, informed family planning, and identification of at-risk relatives. A confirmed molecular diagnosis allows for immediate initiation of immunoglobulin therapy, reducing infection risk. Carrier testing in family members helps prevent recurrence through reproductive options. Our dedicated genetic counsellor explains the results and guides you through emotional and medical decisions.
يتيح الفحص الجيني التشخيص المبكر وبدء العلاج، وتخطيط الأسرة الواعي، وتحديد الأقارب المعرضين للخطر. يقلل من خطر العدوى ويوفر خيارات إنجابية آمنة للمستقبل.
UAE Compliance & Accreditation
- Laboratory operations strictly adhere to Federal Decree-Law No. 41 of 2024 (Art. 87), UAE CDS Law 2026 (Minors), and UAE PDPL for data privacy.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) – ensuring international quality management standards.
- DHA Licensed Facility (9834453) with DHA-licensed phlebotomists and genetic counsellors.
- Home Collection Window: 8 AM – 11 PM, 7 days a week. WhatsApp Support: +971 54 548 8731.
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التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians