Test Price
2,800 AED✅ Home Collection Available
LHCGR Gene Mutation Analysis (NGS) for Male Precocious Puberty in UAE | 2800 AED
Executive Summary & Core Metrics
- ▹Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015‑accredited NGS processing.
- ▹Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (daily 8 AM – 11 PM).
- ▹Clinical Guidance: Complimentary telephonic post‑test consultation for result interpretation.
- ▹Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This test sequences the entire coding region of the LHCGR gene using Next‑Generation Sequencing to detect activating mutations responsible for familial male‑limited precocious puberty (testotoxicosis). It provides definitive molecular confirmation, guides targeted therapy, and informs family genetic counselling.
| Parameter | Our Test (LHCGR NGS) | Closest Alternative |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity – full gene coverage including deep intronic variants | Single‑gene Sanger sequencing: >99% but may miss large deletions |
| Methodology | NGS (Illumina platform) with advanced bioinformatics | Whole Exome Sequencing – broader but slower and costlier |
| Turnaround Time | 3–4 Weeks | 6–10 Weeks (exome) |
| Clinical Utility | Tailored for precocious puberty, direct management decisions | Incidental findings common, may require additional validation |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I understand the anxiety surrounding early puberty in boys. This test specifically identifies activating LHCGR mutations that lead to gonadotropin‑independent testosterone secretion. While the result is highly accurate, it must be correlated with clinical signs and hormonal profiles to confirm true precocious puberty. Early diagnosis empowers families to explore suppressive therapies that preserve growth and bone health.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA‑Licensed (Registration ID: 9294403)
Medication Advisory
⚠️ Do not discontinue any prescribed medication or hormone therapy without consulting your specialist. This test is a diagnostic tool and must not be used as the sole basis for altering treatment.
Safety Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Neonates below 28 days (sample volume constraints)
- Haemodynamically unstable patients
- Individuals without pre‑test genetic counselling session
- Non‑consenting minors (per Federal Decree-Law No. 4 of 2016 on Medical Liability)
Emergency Red Flags
- Sudden onset of headaches, vomiting, visual disturbances
- Rapid pubertal progression (<2 months)
- Signs of increased intracranial pressure
- Severe testicular pain or torsion
If any red flag symptom appears, seek immediate emergency care or call 998. Do not wait for test results.
Patient FAQ & Clinical Guidance
1. What disease does the LHCGR gene test detect?
This genetic test identifies mutations causing familial male‑limited precocious puberty (testotoxicosis), a condition that triggers early androgen secretion independent of pituitary gonadotropins. The disorder is inherited in an autosomal dominant pattern and leads to rapid virilization in young boys. By sequencing the entire LHCGR gene with NGS, we can detect even rare, deep‑intronic variants that Sanger sequencing might miss, providing the clarity needed for targeted endocrine management and family planning.
2. How is the sample collected for this genetic test?
A certified DHA‑licensed phlebotomist collects either a peripheral blood sample, or a single drop of blood on an FTA card—a painless, room‑temperature‑stable method ideal for children. The collection can be done at home via VIP Mobile Phlebotomy or in our facility, with all samples transported under strict cold‑chain conditions. Extracted DNA from prior blood samples is also acceptable. The entire process follows ISO 9001:2015 and UAE PDPL data privacy standards.
3. How long do results take and what do they mean?
Results are typically ready within 3 to 4 weeks from sample receipt at our ISO‑accredited genomics laboratory, delivered via a secure portal with telephonic interpretation support. A positive report identifies the specific LHCGR mutation, confirming the diagnosis at the molecular level. A negative result does not rule out other forms of precocious puberty; further hormonal and imaging work‑up is always advised. Genetic counselling is included before and after testing.
UAE Regulatory & Data Privacy Adherence
This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic counselling and reporting adhere to DHA/MOHAP standards. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
ISO 9001:2015 Certified | Certificate No. INT/EGQ/2509DA/3139 | DHA Facility License: 1143
Medical Editor: Lina Osama Zaki Quteineh, DHA Registration ID 9294403. Content reviewed for accuracy and compliance. Last updated: 2026.
Clinical & Logistical Metadata
| Test Name | LHCGR Gene Mutation Analysis (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral blood or FTA card (dried blood spot) |
| Methodology Used | Next‑Generation Sequencing (Illumina platform) |
| ICD-10-CM Code | E30.1 (Precocious puberty) |
| LOINC Code | 21636-6 (DNA analysis for mutation detection) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Brand: DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians