Test Price
2,800 AED✅ Home Collection Available
LEP Gene Obesity due to Leptin Deficiency Genetic Test in UAE | 2800 AED | DHA Certified
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189:2012 accredited NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation with a DHA-licensed physician.
- Insurance: Direct Billing Verification & instant pre‑approval via WhatsApp +971 54 548 8731.
This high-precision genetic test screens the entire coding region of the LEP gene using Next‑Generation Sequencing (NGS) to identify pathogenic variants linked to severe, early‑onset obesity. It enables targeted endocrine and nutritional management based on definitive molecular diagnosis.
Test Overview & Methodology
The LEP Gene Obesity due to Leptin Deficiency Genetic Test utilizes Next‑Generation Sequencing (NGS) to analyze the full coding region and splice sites of the leptin (LEP) gene. This definitive molecular approach distinguishes congenital leptin deficiency from other forms of monogenic or polygenic obesity.
| Feature | Our Test (LEP NGS) | Closest Alternative (Serum Leptin Assay) |
|---|---|---|
| Precision | 99.9% analytical sensitivity & specificity for all LEP variants | ~95% – cannot detect receptor/post‑receptor defects |
| Methodology | Next‑Generation Sequencing (NGS) with full bioinformatic validation | Immunoassay (ELISA/RIA) – hormone level measurement only |
| Speed | Definitive genetic answer in 14-21 business days | Same‑day to 3 days, but requires repeated sampling |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
"A homozygous or compound heterozygous LEP mutation confirms congenital leptin deficiency, a condition that can be managed with recombinant leptin therapy. However, this genetic test must always be interpreted alongside clinical phenotype and biochemical leptin levels; it is part of a comprehensive endocrine evaluation."
Medication Advisory
Do not discontinue prescribed medication or therapeutic diets without consulting your doctor. This test is an elective diagnostic aid and does not replace ongoing clinical management.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Not intended for standalone emergency diagnosis; must be performed in stable, non‑critically ill patients.
- Minors: Mandatory parental/guardian consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability; genetic counselling required prior to sampling.
- Red Flag – Seek Immediate Emergency Care: If the patient experiences severe hyperphagia leading to acute metabolic decompensation, dyspnoea, or altered consciousness, proceed to the nearest emergency room.
- Specimen Integrity: Blood drawn on FTA card must follow cold‑chain protocol; sample rejection if haemolysis exceeds 2+.
Patient FAQ & Clinical Guidance
1. How is the LEP genetic test performed and what sample is needed?
The test utilizes a simple blood draw or a dried blood spot on an FTA card. Our VIP Mobile Phlebotomy service collects the sample during a scheduled home visit between 8 AM and 11 PM, ensuring temperature-controlled cold-chain integrity.
2. What do the results mean and how will I understand them?
A positive result identifies a pathogenic LEP variant confirming congenital leptin deficiency. You will receive a telephonic clinical guidance session with a DHA-licensed physician to explain the implications and outline potential treatment pathways, such as recombinant leptin therapy.
3. Does insurance cover this test and what is the turnaround time?
Many UAE insurers provide coverage for genetic testing related to monogenic obesity. We offer direct billing verification via WhatsApp at +971 54 548 8731. Results are typically delivered electronically within 14-21 business days.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures comply with Federal Decree-Law No. 4 of 2016 on Medical Liability. Patient data is encrypted and securely processed in accordance with UAE regulatory standards.
Clinical & Logistical Metadata
| Test Name | LEP Gene Obesity due to Leptin Deficiency Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 14-21 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | E34.8 |
| LOINC Code | 21621-4 |
| DHA Facility License & Address | 1143 - Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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