Test Price
2,800 AEDโ Home Collection Available
LAMTOR2 Gene Sequencing (p14/MP1) for Primary Immunodeficiency Syndrome โ DHA Licensed Laboratory
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Dedicated Telephonic Post-Test Clinical Guidance for result interpretation with a DHA-licensed genetics specialist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 โ instant confirmation before sample collection.
Test Overview & Methodology
The LAMTOR2 gene test detects pathogenic variants causing a rare primary immunodeficiency syndrome characterized by osteopetrosis, eczema, and recurrent infections. This advanced NGS assay offers definitive diagnosis and guides personalized management, including hematopoietic stem cell transplantation and family counseling.
High-coverage next-generation sequencing (Illumina platform) targets the entire LAMTOR2 coding region ยฑ10 base pairs of intronic flanking, with Sanger confirmation for all clinically significant variants. Copy number variant analysis is included.
| Feature | Our Test (ISO 9001:2015) | Closest Alternative (Generic Immunodeficiency Panel) |
|---|---|---|
| Methodology | High-Coverage NGS (Illumina) with Sanger confirmation, targeting entire LAMTOR2 coding region ยฑ10 bp intronic flanking | Broad multi-gene panel with variable coverage; may miss deep intronic or copy-number variants |
| Diagnostic Sensitivity | >99.9% for SNVs, indels, and CNVs (validated by clinical concordance study) | ~85โ90% due to incomplete gene representation and limited CNV analysis |
| Turnaround Time | 3โ4 Weeks (Expedited 14-day option available) | 6โ8 Weeks standard |
| Price | 2800 AED | 4500โ6000 AED |
Physician Insight & Safety Protocols
โAs a consultant in medical genetics, I emphasize that LAMTOR2 sequencing must be correlated with full immunological and clinical assessment. A negative result does not exclude all forms of primary immunodeficiency. Comprehensive family counseling and further immunophenotyping are recommended before definitive clinical decisions.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
Advisory & Medication Safety
โ Do not discontinue or alter prescribed medications without consulting your physician.
Inform your doctor of all current treatments to ensure safe sample collection and accurate result interpretation.
Exclusion Criteria for Sample Collection
- Active febrile illness โฅ38.5ยฐC or systemic infection requiring acute therapy.
- Known coagulopathy, platelet count <50,000/ยตL, or ongoing anticoagulation not cleared by physician.
- Inability to provide informed consent per Federal Decree-Law No. 4 of 2016 on Medical Liability (guardian consent mandatory for minors).
- Emergency red flags: sudden pustular rash with fever, severe respiratory distress, or signs of sepsis โ seek immediate emergency care.
Patient FAQ & Clinical Guidance
1. What is the LAMTOR2 gene test and why is it performed?
The LAMTOR2 gene test identifies mutations that cause a rare form of primary immunodeficiency with osteopetrosis and eczema. It confirms the molecular diagnosis, enables carrier screening, and guides life-saving management such as hematopoietic stem cell transplantation. This test is crucial for families with a history of early-onset immune failure and skeletal abnormalities.
2. How accurate is the home collection method for this genetic test?
Home collection uses a dried blood spot (FTA card) which preserves DNA integrity during ambient shipment. This method achieves diagnostic sensitivity equivalent to venous blood, validated by our ISO-certified laboratory, maintaining 99.9% analytical accuracy for NGS-based sequencing.
3. Will my insurance cover this test and how can I verify coverage?
Most UAE insurance plans cover genetic testing with pre-authorization for DHA-approved indications. Verify your coverage instantly via WhatsApp at +971545488731. Our team checks your policy against approved indications for primary immunodeficiency and assists with all documentation required under UAE data privacy standards.
UAE Regulatory & Data Privacy Adherence
Your Data and Health Information Are Protected
- Personal Data Protection: All genetic data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). Your data is encrypted and not shared without explicit consent.
- Health Information Governance: Laboratory operations adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring secure electronic health records and data exchange.
- Clinical Safety & Patient Consent: Informed consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability, and all sample collections are performed under strict medical supervision.
- Licensed Facility: DNA Labs UAE โ DHA Facility License No. 1143, located at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | LAMTOR2 Gene Sequencing (p14/MP1) |
| Price (AED) | 2800 |
| Turnaround Time | 3โ4 Weeks (Expedited 14-day option available) |
| Sample Type / Matrix | Peripheral Whole Blood, Dried Blood Spot (FTA Card) |
| Methodology Used | High-Coverage NGS (Illumina) with Sanger Confirmation |
| ICD-10-CM Code | D82.9 |
| LOINC Code | 21694-0 |
| DHA Facility License & Laboratory Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians