Test Price
2,800 AED✅ Home Collection Available
KRT6B Gene Pachyonychia Congenita Type 4 Genetic Test | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
The KRT6B Genetic Test provides definitive molecular diagnosis of Pachyonychia Congenita Type 4 (PC‑K6b) through high‑resolution next‑generation sequencing (NGS) of the keratin 6B gene, achieving 99.9% analytical sensitivity. This ISO 9001:2015 accredited assay enables precise variant identification, informs dermatological management, and supports genetic counselling. Sample collection is performed via VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM, ensuring patient convenience and specimen integrity. Post‑test clinical guidance calls and direct insurance billing via WhatsApp are included.
Test Overview & Methodology
The KRT6B Genetic Test sequences the entire keratin 6B gene to identify pathogenic variants responsible for Pachyonychia Congenita Type 4 (PC‑K6b) – a rare autosomal dominant ectodermal dysplasia marked by painful palmoplantar keratoderma, hypertrophic nail dystrophy, and oral leukokeratosis. Comprehensive gene coverage ensures detection of both known and novel mutations, enabling accurate diagnosis and targeted management decisions.
| Feature | Our NGS Test (ISO Lab) | Standard Sanger Sequencing (Alternative) |
|---|---|---|
| Method | Next‑Generation Sequencing (full gene coverage) | Single‑amplicon Sanger (limited to known hotspots) |
| Precision | 99.9% analytical sensitivity & specificity | ~98% for targeted regions |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Sample | Blood, Extracted DNA, or One‑Drop Blood on FTA Card | Blood only |
| Cost | 2,800 AED | 4,000+ AED |
| Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Variable |
| Home Collection | Included (VIP Phlebotomist) | Often not available |
Physician Insight & Safety Protocols
“As a DHA‑licensed Consultant Medical Genetics, I emphasize that a positive KRT6B variant provides molecular confirmation of PC‑K6b, but full clinical correlation with dermatological findings and a detailed three‑generation pedigree is essential. A negative result does not exclude other genodermatoses, so we interpret all findings within the complete phenotype. Please continue any prescribed therapies and consult your physician before making any changes.”
— Lina Osama Zaki Quteineh, DHA Registration ID: 9294403
Medication Safety Advisory
⚠ Medication Safety Warning
Do not discontinue or alter any prescribed medication without consulting your treating physician. This genetic test does not replace ongoing dermatological care.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Blood transfusion within the last 2 weeks (DNA contamination risk if using whole blood)
- Acute febrile illness requiring medical stabilization prior to specimen collection
- Seek immediate care if you experience prolonged bleeding, fainting, or signs of infection at the draw site after sample collection
Patient FAQ & Clinical Guidance
1. What exactly does the KRT6B gene test detect, and why is it important?
The KRT6B Genetic Test sequences the keratin 6B gene to diagnose Pachyonychia Congenita Type 4, a rare autosomal dominant skin disorder characterized by painful palmoplantar keratoderma, hypertrophic nail dystrophy, and oral leukokeratosis. Early molecular diagnosis allows targeted management, genetic counselling, and informed family planning.
2. How is the sample collected, and do I need to prepare in any way?
A certified mobile phlebotomist collects a small blood sample or an FTA card spot in your home; no fasting is required, but a pre‑test genetic counselling session is mandatory to document family history and discuss implications. Home collection is available daily from 8 AM to 11 PM.
3. Will my insurance cover this, and how quickly will I receive results?
Results return in approximately 3–4 weeks. We verify insurance eligibility directly via WhatsApp (+971 54 548 8731) before your appointment and assist with direct billing to your insurer.
UAE Regulatory & Data Privacy Adherence
All genetic data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent follows Federal Decree-Law No. 4 of 2016 on Medical Liability. Results are released only to the ordering physician or the patient after verification.
Clinical & Logistical Metadata
| Test Name | KRT6B Gene Pachyonychia Congenita Type 4 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (peripheral), extracted DNA, or one‑drop blood on FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) – full KRT6B gene coverage |
| ICD-10-CM Code | Q84.5 |
| LOINC Code | 94851-8 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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