Test Price
2,800 AED✅ Home Collection Available
KRIT1 Gene Cerebral Cavernous Malformations Type 1 Genetic Test in UAE
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO-certified next-generation sequencing, validated against international genetic databases.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Post-test telephonic guidance with a DHA-licensed physician to interpret results and recommend next steps.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This KRIT1 Genetic Test detects pathogenic variants in the KRIT1 gene, responsible for familial cerebral cavernous malformations type 1, a hereditary vascular disorder that leads to abnormal, leaky blood vessels in the brain and spinal cord. Using next-generation sequencing, it offers near-complete coverage of the coding region and splice sites, confirming a genetic diagnosis with unmatched precision.
| Feature | Our KRIT1 NGS Test | Closest Alternative (MRI / Standard Panel) |
|---|---|---|
| Precision / Sensitivity | >99.9% analytical sensitivity for single-nucleotide variants and small indels | Imaging visualises lesions but cannot confirm genetic cause; limited variant panels miss rare mutations |
| Methodology | Next-generation sequencing with full bioinformatics analysis | Sanger sequencing of selected exons or brain MRI/MRA |
| Turnaround | 3-4 weeks | Varies; imaging immediate, but genetic confirmation may take 6-8 weeks if referred |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403), notes: A positive KRIT1 mutation confirms the hereditary form of cerebral cavernous malformations; however, clinical correlation with brain imaging and family history is essential. This test should be interpreted by a clinical geneticist or neurologist and never as a standalone peace of mind screen without proper counselling.
Medication Advisory
Important Medication Advisory
Do not discontinue any prescribed medication without consulting your doctor. This genetic test does not require stopping antiplatelet or anticoagulant therapy.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Minors below 18 without a legal guardian informed consent.
- Individuals unable to understand genetic counselling implications.
- Samples collected during acute neurological crisis such as acute stroke.
Emergency Red Flags
Seek immediate medical attention if you experience sudden severe headache, seizure, new-onset focal neurological deficit such as weakness, numbness or vision loss, or unexplained loss of consciousness.
Patient FAQ & Clinical Guidance
1. What does the KRIT1 gene test detect?
This next-generation sequencing test identifies pathogenic variants in the KRIT1 gene responsible for familial cerebral cavernous malformations type 1, enabling accurate diagnosis and family risk assessment.
2. How is the sample collected?
A small blood sample, extracted DNA, or a single drop of blood on an FTA card is collected through a painless ISO-certified VIP mobile phlebotomy service with temperature-controlled cold-chain logistics, available daily from 8 AM to 11 PM, with no need to alter your medications.
3. Who should consider this genetic test?
Individuals with multiple family members affected by cerebral cavernous malformations, those with a personal history of brain lesions on MRI, or relatives of a known mutation carrier should consider testing after mandatory genetic counselling.
4. What is the turnaround time for results?
Results are typically available within 3 to 4 weeks from sample receipt, as comprehensive bioinformatics analysis and variant interpretation are performed for each specimen.
5. Does insurance cover this genetic test?
Coverage varies by insurance provider. Direct billing verification is available via WhatsApp at +971 54 548 8731 to confirm your policy benefits prior to testing.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
All genetic testing services at DNA Labs UAE comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Testing is performed in a DHA-regulated facility under license number 1143.
Clinical & Logistical Metadata
| Test Name | KRIT1 Gene Cerebral Cavernous Malformations Type 1 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 weeks |
| Sample Type / Matrix | Peripheral whole blood, extracted DNA, or FTA card blood spot |
| Methodology Used | Next-generation sequencing (NGS) with full bioinformatics analysis |
| ICD-10-CM Code | Q28.3 |
| LOINC Code | 77415-0 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians