Test Price
2,800 AED✅ Home Collection Available
KLK4 Gene Amelogenesis Imperfecta Type 2A1 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Test Overview at a Glance
99.9% diagnostic sensitivity via ISO 9001:2015 certified next-generation sequencing for the KLK4 gene. This test detects pathogenic variants causing Amelogenesis Imperfecta Type 2A1, an autosomal recessive enamel defect. Premium hospital-grade home phlebotomy with temperature-controlled cold-chain transport ensures uncompromised sample integrity. Results include a comprehensive clinical report and mandatory genetic counselling session. Direct billing verification via WhatsApp at +971 54 548 8731. Fixed all-inclusive price of 2800 AED with results delivered within 3–4 weeks.
Test Overview & Methodology
The KLK4 Gene Genetic Test uses next-generation sequencing to analyse the full coding region and flanking intronic sequences of the KLK4 gene. This advanced molecular approach identifies single nucleotide variants, small insertions, and deletions responsible for autosomal recessive Amelogenesis Imperfecta Type 2A1. Unlike traditional Sanger sequencing, NGS provides comprehensive coverage of all exons simultaneously, delivering superior diagnostic yield for rare enamel developmental disorders. Results must be interpreted in conjunction with a complete clinical dental and family history evaluation.
| Feature | Our NGS Test | Closest Alternative (Sanger) |
|---|---|---|
| Diagnostic Precision | 99.9% Analytic Sensitivity | ~95% (limited to known variants) |
| Methodology | Next-Generation Sequencing (full gene + flanking regions) | Sanger Sequencing (targeted exons only) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Cost | 2800 AED | 3500 AED (avg.) |
Physician Insight & Safety Protocols
“The KLK4 NGS assay offers high-resolution detection of pathogenic mutations underlying hereditary enamel malformation. A definitive genetic diagnosis is essential for appropriate dental management and family counselling. However, all findings require correlation with clinical examination, and irreversible dental treatments should never be initiated based solely on a molecular report.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Precautionary Guidance
Important Medication & Treatment Advisory
Genetic test results do not replace ongoing clinical care. Do not alter, suspend, or discontinue any prescribed medication or dental treatment plan without explicit consultation with your treating physician. This test provides diagnostic information only and is not intended to guide emergency interventions.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent; active blood-borne infection; recent blood transfusion (less than 2 weeks prior).
- Exclusion: Patients who cannot undergo standard venipuncture or provide an FTA card sample.
- ER Red Flag: Severe allergic reaction (anaphylaxis) following blood collection – seek immediate emergency care.
- ER Red Flag: Uncontrolled bleeding, expanding haematoma, or signs of infection at the puncture site.
Patient FAQ & Clinical Guidance
1. What is the KLK4 gene test used for?
This NGS test identifies pathogenic variants in the KLK4 gene causing autosomal recessive Amelogenesis Imperfecta Type 2A1. It enables precise diagnosis of hereditary enamel malformation, facilitates informed genetic counselling for families, and supports early dental care planning. The direct answer snippet is: “The KLK4 gene NGS test detects mutations responsible for hereditary enamel malformation, aiding in accurate diagnosis and family planning.”
2. How is the sample collected?
A comfortable home blood draw is performed by our trained phlebotomist: a single drop of blood on an FTA card or a standard whole blood sample via venipuncture. The sample is transported under strict temperature-controlled cold-chain conditions to preserve optimal DNA integrity. The direct answer snippet is: “A premium home phlebotomy service collects one drop of blood on an FTA card or whole blood with strict cold-chain transport.”
3. What is the turnaround time and cost?
Results are delivered within 3–4 weeks at a fixed all-inclusive price of 2800 AED. This covers full gene sequencing, a comprehensive clinical report, and a mandatory post-test genetic counselling session. The direct answer snippet is: “Results are released within 3–4 weeks for 2800 AED, including full gene analysis and a mandatory genetic counselling appointment.”
UAE Regulatory & Data Privacy Adherence
Comprehensive Legal & Data Protection Framework
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – Encrypted genomic data storage and processing.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – Secure digital health information exchange.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – Patient consent and clinical safety standards for genetic testing.
- ISO 9001:2015 Certified Facility | Cert: INT/EGQ/2509DA/3139.
- DHA/MOHAP Standard Nomenclature & Licensed Facility.
Clinical & Logistical Metadata
| Test Name | KLK4 Gene Amelogenesis Imperfecta Type 2A1 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (FTA Card or Venipuncture) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene + Flanking Regions |
| ICD-10-CM Code | K00.5, Z13.71, Z82.79 |
| LOINC Code | 77634-5 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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