Test Price
2,800 AED✅ Home Collection Available
KLHL3 Gene Pseudohypoaldosteronism Type 2D Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Executive Summary
Our KLHL3 Gene Pseudohypoaldosteronism Type 2D NGS Test delivers 99.9% diagnostic sensitivity through ISO-certified next-generation sequencing, in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Experience hospital-grade VIP mobile phlebotomy with temperature-controlled cold-chain home collection, available daily from 8 AM to 11 PM, plus complimentary telephonic clinical guidance for result interpretation. Verify your insurance coverage instantly via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This test sequences the entire coding region of the KLHL3 gene using Next Generation Sequencing to diagnose Pseudohypoaldosteronism Type 2D, a rare monogenic hypertension syndrome. It aids in confirming the diagnosis, guiding thiazide diuretic therapy, and screening at-risk family members. The methodology employs targeted deep sequencing of all exons, splice sites, and copy number variations (CNVs) with a diagnostic sensitivity of 99.5% for point mutations and greater than 95% for deletions.
| Feature | Our KLHL3-Specific NGS Test | Broad Hypertension Gene Panel NGS |
|---|---|---|
| Gene Coverage | Targeted deep sequencing of KLHL3 exons, splice sites & CNV | Multiple genes (~20-50), often lower depth for KLHL3 |
| Diagnostic Sensitivity | 99.5% for point mutations, >95% for deletions | 90-95% for SNVs; may miss deep intronic variants |
| Turnaround Time | 3 – 4 weeks | 4 – 6 weeks |
| Price (AED) | 2,800 | 4,500 – 6,000 |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I understand the profound impact a rare genetic diagnosis can have on patients and their families. This targeted KLHL3 sequencing provides definitive molecular confirmation of Pseudohypoaldosteronism Type 2D, enabling precise management of hypertension and electrolyte imbalances. The results empower clinicians to tailor thiazide therapy effectively — but always correlate genetic findings with a full clinical evaluation before adjusting any prescribed regimen.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory Notice
Medication Guidance
Never discontinue, reduce, or alter prescribed antihypertensive or potassium-modifying medications without direct supervision from your treating physician. Abrupt changes may trigger dangerous blood pressure fluctuations or life-threatening electrolyte disturbances.
Exclusion Criteria & Emergency Red Flags
Safety & Eligibility Checks
- Exclusion Criteria: Pregnant or breastfeeding women should defer non-urgent genetic testing. Recent blood transfusion (less than 2 weeks) may interfere with germline DNA analysis and requires rescheduling.
- Emergency Red Flags: Seek immediate medical attention if you experience sudden severe dizziness, heart palpitations, or muscle weakness — these may indicate life-threatening hyperkalemia exceeding 6.5 mmol/L.
Patient FAQ & Clinical Guidance
1. What is the KLHL3 gene test for pseudohypoaldosteronism type 2D?
This genetic test analyses the KLHL3 gene to confirm a diagnosis of monogenic hypertension known as Pseudohypoaldosteronism Type 2D. It detects single nucleotide variants, small insertions/deletions, and copy number changes that impair renal salt handling, helping your doctor tailor the most effective blood pressure medication.
2. How long does it take to receive the test results?
Results are delivered within 3 to 4 weeks after sample collection, ensuring each step of NGS library preparation, sequencing, and bioinformatic review meets rigorous quality standards. In certain cases, a faster turnaround may be arranged for urgent clinical need.
3. Will my insurance cover this genetic test in the UAE?
We provide direct billing verification via WhatsApp; most UAE insurers cover medically indicated genetic tests like KLHL3 sequencing when prior authorization is obtained. Contact +971 54 548 8731 with your Emirates ID and insurance card for an instant eligibility check.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and adheres strictly to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient genomic data processing, storage, and sharing. Our laboratory information systems comply with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring encrypted data transmission and secure electronic health record integration. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability, guaranteeing that every test is performed with informed consent and full accountability. Your genetic data remains confidential and is never shared with third parties without your explicit written authorization.
Clinical & Logistical Metadata
| Test Name | KLHL3 Gene Pseudohypoaldosteronism Type 2D Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 – 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next Generation Sequencing (NGS) — targeted deep sequencing of KLHL3 exons, splice sites, and CNV analysis |
| ICD-10-CM Code | E27.4 |
| LOINC Code | 94219-0 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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