Test Price
2,800 AED✅ Home Collection Available
KCNJ11 Gene Hyperinsulinemic Hypoglycemia Type 2 Genetic Test | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Executive Summary
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- ✓ Premium Logistics: Hospital‑Grade Collection with ISO‑Certified Cold‑Chain Transport and VIP Mobile Phlebotomy (8 AM – 11 PM).
- ✓ Clinical Guidance: Telephonic post‑test result interpretation by a DHA‑licensed Consultant Medical Genetics.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Core Metrics
- ✓ Price: 2,800 AED (all inclusive).
- ✓ Turnaround Time: 21–28 calendar days from receipt of specimen.
- ✓ Methodology: Clinical NGS with full coding region coverage and bioinformatic variant interpretation.
- ✓ Pre‑requisite: Mandatory genetic counselling session with pedigree charting prior to sample collection.
Test Overview & Methodology
This test sequences the entire coding region of the KCNJ11 gene to identify pathogenic variants causing hyperinsulinemic hypoglycemia type 2 (congenital hyperinsulinism). With a turnaround of 21–28 days, our NGS‑based analysis delivers the highest diagnostic yield, enabling precise, individualized treatment for affected infants and adults. Genetic counselling with pedigree charting is mandatory before sample collection.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Sensitivity | 99.9% (full gene coverage) | ~85% (targets known mutations only) |
| Methodology | Next‑Generation Sequencing (NGS) with bioinformatic variant interpretation | Sanger sequencing of selected exons |
| Turnaround Time | 21–28 days | 14–21 days (may require reflex NGS) |
Physician Insight & Safety Protocols
“As a Consultant in Medical Genetics, I emphasize that genetic results must be interpreted within the full clinical picture. KCNJ11 mutations can present with life‑threatening neonatal hypoglycaemia; thus, rapid molecular confirmation is critical. This test provides the clarity needed to guide therapy, but it does not replace continuous glucose monitoring and expert endocrine management. A mandatory pre‑test genetic counselling session ensures informed consent and accurate pedigree interpretation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
⚠️ Medication Advisory: Do not discontinue or adjust any prescribed medication (e.g., diazoxide, octreotide) without explicit consultation with your treating physician. Test results do not constitute immediate management changes.
Safety Exclusion Criteria & Emergency Red Flags
- Neonates with persistent hypoglycaemia (glucose <2.5 mmol/L) must be under continuous medical supervision prior to collection.
- Do not postpone urgent clinical care for genetic results. If the patient develops seizures, lethargy, or poor feeding, seek emergency care immediately.
- Home collection is not permitted if the patient has a central line infection or unstable vital signs; hospital‑based sampling may be required.
- Individuals on systemic anticoagulation must inform the phlebotomist; a safety assessment will be conducted before venipuncture.
Patient FAQ & Clinical Guidance
1. What does the KCNJ11 NGS test detect, and why is it important?
This test identifies all pathogenic variants in the KCNJ11 gene that cause congenital hyperinsulinism, allowing precise diagnosis and guiding life‑saving therapy such as diazoxide or subtotal pancreatectomy. Early molecular confirmation is critical in neonatal hypoglycaemia management.
2. How should I prepare for the home blood collection?
No fasting is required; however, please share your clinical history and any anticoagulant use with our team before the visit. A genetic counselling session must be completed prior to scheduling the collection.
3. How reliable are the results, and who interprets them?
With 99.9% diagnostic sensitivity and ISO‑accredited bioinformatics, results are clinically actionable. A DHA‑licensed Consultant Medical Genetics provides a telephonic interpretation session after results are released.
4. What is the turnaround time, and can it be expedited?
Standard turnaround is 21–28 calendar days from specimen receipt. Expedited processing is not available due to the comprehensive nature of NGS analysis and bioinformatic interpretation.
5. How do I schedule the mandatory genetic counselling session?
Contact our team via WhatsApp at +971 54 548 8731 to arrange a pre‑test genetic counselling session with pedigree charting. This session is required before any sample collection can proceed.
UAE Regulatory & Data Privacy Adherence
Data Protection & Clinical Governance Framework
- All genetic data is processed and stored in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Clinical information systems and health data handling adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Patient consent and clinical safety protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Results are shared only with the requesting physician and the patient through secure, encrypted channels.
Clinical & Logistical Metadata
| Test Name | KCNJ11 Gene Hyperinsulinemic Hypoglycemia Type 2 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 calendar days |
| Sample Type / Matrix | Peripheral whole blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM to 11 PM |
| Methodology Used | Next‑Generation Sequencing (NGS) with full coding region coverage and bioinformatic variant interpretation |
| ICD-10-CM Code | E16.1 |
| LOINC Code | 48296-0 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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