Test Price
2,800 AED✅ Home Collection Available
IYD Gene Thyroid Dyshormonogenesis Type 4 NGS Genetic Analysis in UAE | AED 2,800 | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 15189 and ISO 9001:2015 accredited processing.
- Premium Logistics: VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Post‑test telephonic consultation with a DHA‑licensed clinician to interpret results within the full clinical picture.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next‑generation sequencing (NGS) assay examines the entire coding region of the IYD (iodotyrosine deiodinase) gene to detect pathogenic variants causing thyroid dyshormonogenesis type 4 – a congenital hypothyroidism often presenting with goiter. The test is ordered by endocrinologists, geneticists, and primary care physicians to confirm genetic aetiology, guide treatment, and screen at‑risk family members.
| Feature | Our Test (NGS) | Alternative Methods |
|---|---|---|
| Precision | >99.9% sensitivity for SNVs, indels, and CNVs | Targeted mutation panels miss rare or novel variants |
| Methodology | Illumina NovaSeq, GRCh38 alignment, ACMG variant interpretation | Sanger sequencing of limited exons; slower and less comprehensive |
| Turnaround Time | 3–4 weeks | Sequential single‑gene testing often requires 6–8 weeks |
Physician Insight & Safety Protocols
“A positive IYD mutation confirms the genetic aetiology of congenital hypothyroidism but must be correlated with thyroid function tests and clinical examination. This test alone does not dictate immediate therapy changes; always discuss results with your treating endocrinologist.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
Advisory Notice
Do not discontinue prescribed thyroid hormone replacement or any other medication without explicit consultation with your physician. Abrupt cessation can lead to severe hypothyroidism, particularly in infants and children.
Exclusion Criteria & Emergency Red Flags
- Patients currently undergoing radioiodine therapy must wait at least 6 weeks before sample collection.
- Blood samples from neonates must be collected in a hospital setting; home collection is not offered for infants under 28 days.
- Seek immediate medical attention if the patient develops lethargy, poor feeding, respiratory distress, or hypothermia – signs of myxedema coma.
- For minors, the test is only processed after mandatory genetic counselling and consent as per Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What does a positive IYD gene test mean for my child’s thyroid health?
A positive IYD mutation confirms a genetic form of congenital hypothyroidism that requires lifelong thyroid hormone replacement but generally has a normal prognosis when treated early. This result explains the cause of dyshormonogenesis type 4, guiding dose adjustments and family planning.
2. Can I order this test myself without a doctor’s referral?
While individuals can self‑request, UAE law mandates pre‑test genetic counselling and a referral from a DHA‑licensed physician for any genetic analysis. Our team coordinates the mandatory counselling session and obtains the necessary prescription before scheduling the draw.
3. How secure is my genetic data under UAE law?
Your DNA data is encrypted and stored on UAE‑based servers fully compliant with the Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. We never share identifiable genetic information without your explicit, written consent, and results are discussed only via secure channels.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
- DHA‑Licensed Facility No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) and ISO 15189 for medical laboratories.
- All genetic data handled in accordance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 on Health ICT.
- Clinical safety and patient consent comply with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
WhatsApp support & appointment: +971 54 548 8731
Clinical & Logistical Metadata
| Test Name | IYD Gene Thyroid Dyshormonogenesis Type 4 NGS Genetic Analysis |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily 8 AM–11 PM |
| Methodology Used | Next‑Generation Sequencing (Illumina NovaSeq, GRCh38 alignment, ACMG variant interpretation) |
| ICD‑10‑CM Code | E03.1 (Congenital hypothyroidism due to dyshormonogenesis) |
| LOINC Code | 94836-5 (IYD gene mutation analysis) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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