Test Price
1,000 AED✅ Home Collection Available
Huntington Disease CAG Repeat Expansion Test (HTT Gene Mutation Detection) in the UAE
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity via ISO‑accredited PCR fragment and STR analysis with capillary electrophoresis.
- Premium Logistics: VIP mobile phlebotomy with temperature‑controlled cold‑chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Mandatory pre‑ and post‑test genetic counselling integrated with telephonic result interpretation by a Consultant Medical Genetics specialist.
- Insurance Support: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The Huntington Disease CAG Repeat Expansion Test precisely quantifies the trinucleotide repeat expansion in the HTT gene using PCR‑based fragment analysis and STR sizing via capillary electrophoresis. It serves as the definitive molecular diagnostic for Huntington disease and provides critical presymptomatic screening for at‑risk relatives in the UAE. The procedure is performed under DHA‑approved protocols with a standard 10‑working‑day turnaround.
Clinical Intent: Confirm diagnosis in patients presenting with motor, cognitive, or psychiatric symptoms; provide predictive information for asymptomatic adults with a confirmed family history, always paired with comprehensive genetic counselling.
| Feature | Our DHA‑Approved Test | Closest Alternative (Standard PCR) |
|---|---|---|
| Methodology | PCR + Fragment & STR Analysis (capillary electrophoresis) | PCR with agarose gel sizing only |
| Sensitivity | 99.9% – resolves exact CAG repeat length (normal, intermediate, pathogenic) | ~90% – may misclassify borderline alleles |
| Turnaround Time | 10 working days (sample received by 11 AM Tuesday) | 10–14 working days |
Physician Insight & Safety Protocols
"A positive HTT expansion is a life‑altering finding that necessitates comprehensive pre‑ and post‑test genetic counselling. As a Consultant Medical Genetics specialist, I emphasize the importance of integrating molecular results with a detailed neurological examination and family history. Even a negative result does not exclude other hereditary ataxias or movement disorders. Predictive testing in asymptomatic adults must always be performed within a multidisciplinary framework."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403)
Medication Safety Advisory
Do not discontinue, alter, or adjust prescribed medication without direct consultation with your treating physician.
Patient Exclusion Criteria & Emergency Red Flags
- Exclusion criteria: Unstable psychiatric condition, severe cognitive impairment preventing informed consent. For minors, legal guardian consent and pre‑test genetic counselling are mandatory under Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Seek immediate medical attention if you experience: new‑onset severe depression, suicidal thoughts, uncontrollable chorea, swallowing difficulties, or rapid cognitive decline.
Patient FAQ & Clinical Guidance
1. What is the Huntington Disease CAG Repeat Expansion Test and why is it performed?
This test detects and precisely measures the CAG trinucleotide repeat expansion in the HTT gene, confirming a diagnosis of Huntington disease or revealing presymptomatic risk with 99.9% diagnostic sensitivity. It is performed to establish a definitive molecular diagnosis in symptomatic individuals and to provide predictive testing for asymptomatic adults with a family history, always within a framework of genetic counselling.
2. Who should consider this genetic test in the UAE?
Adults presenting with motor symptoms (chorea, dystonia, incoordination), cognitive decline, psychiatric changes, or a confirmed family history of Huntington disease are candidates for testing. Pre‑test genetic counselling with a qualified specialist is mandatory to ensure informed decision‑making.
3. How are the results interpreted and when will I receive them?
A result of 40 or more CAG repeats is considered fully pathogenic; 36–39 repeats indicate intermediate penetrance; 27–35 repeats are unstable but not associated with disease onset. The detailed clinical report is delivered within 10 working days following sample receipt.
4. What sample type is required and how is it collected?
A standard peripheral whole blood sample (4 mL in a lavender‑top EDTA tube) is required. VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection are available daily from 8 AM to 11 PM for your convenience.
UAE Regulatory & Data Privacy Adherence
✅ Fully compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
✅ Laboratory accredited ISO 9001:2015 under the corporate governance of DNA Labs UAE.
✅ Clinical safety and patient consent protocols strictly adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability.
✅ All test results and patient data are encrypted and stored in compliance with UAE federal data privacy regulations.
Clinical & Logistical Metadata
| Test Name | Huntington Disease CAG Repeat Expansion Test (HTT Gene Mutation Detection) |
| Price (AED) | 1,000 AED |
| Turnaround Time | 10 Working Days |
| Sample Type / Matrix | Peripheral Whole Blood (Lavender‑top EDTA Tube) |
| Methodology Used | PCR‑based Fragment Analysis & STR Sizing (Capillary Electrophoresis) |
| ICD-10-CM Code | G10, Z15.89, Z82.3 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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