Test Price
2,800 AED✅ Home Collection Available
HTRA1 Gene (CARASIL) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- ✓ 99.9% Diagnostic Sensitivity – ISO‑accredited processing ensures clinical‑grade precision for HTRA1 mutation detection.
- ✓ Premium Logistics – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection, available daily from 8 AM to 11 PM.
- ✓ Clinical Guidance – Telephonic post‑test consultation by a DHA‑licensed Consultant Medical Geneticist to interpret results.
- ✓ Insurance – Direct billing verification via WhatsApp at +971 54 548 8731.
- ✓ Turnaround – 3–4 weeks for comprehensive NGS analysis.
Test Overview & Methodology
This Next‑Generation Sequencing (NGS) test screens the HTRA1 gene for biallelic mutations causing CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy), an inherited small‑vessel disease. By analyzing all coding exons at high depth, it identifies pathogenic variants linked to early‑onset stroke, cognitive decline, and vascular dementia, empowering families and physicians in the UAE with actionable genetic data.
| Feature | Our Test (UAE Gold Standard) | Closest Alternative |
|---|---|---|
| Precision | Full‑gene NGS with 1000x depth, >99.9% sensitivity | Targeted Sanger sequencing of selected exons only |
| Method | Illumina‑based NGS, ISO 9001:2015 lab | Single‑gene Sanger; lower resolution |
| Speed & Support | 3–4 weeks with DHA‑licensed genetic counselling | 4–6 weeks; counselling may not be integrated |
Physician Insight & Safety Protocols
"Detection of biallelic pathogenic variants in HTRA1 confirms the diagnosis of CARASIL, a rare but clinically significant cause of early‑onset cerebral small vessel disease. A comprehensive genetic workup, including MRI correlation and family segregation analysis, is essential for accurate risk stratification and counselling."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Safety Advisory
Do not discontinue or adjust prescribed medications (e.g., antiplatelets, statins) without consulting your treating physician. Genetic results do not replace ongoing clinical management.
Emergency Red Flags
- Sudden onset of severe headache, confusion, or vision loss
- Acute weakness or numbness on one side of the body (possible stroke)
- Loss of balance, difficulty speaking, or abrupt personality change
If any sign appears, proceed immediately to the nearest emergency department.
Exclusion Criteria
Test not recommended for individuals under 18 without court‑approved consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. For women who are pregnant but seeking non‑urgent genetic screening, defer until after delivery. Recent blood transfusion (<2 weeks) may cause sample inadequacy.
Patient FAQ & Clinical Guidance
1. What does a positive HTRA1 genetic test indicate for my health and family?
A positive result confirms biallelic pathogenic variants in HTRA1, establishing a diagnosis of CARASIL — a rare autosomal recessive cerebral small vessel disease. Family cascade screening and genetic counselling are strongly recommended for all first-degree relatives.
2. How is the sample collected and what preparation is needed?
No fasting is required. A trained phlebotomist will collect a peripheral whole blood sample or a dried blood spot on an FTA card at your home, office, or our facility. Collection is available daily from 8 AM to 11 PM via our VIP Mobile Phlebotomy service.
3. Is this genetic test covered by UAE health insurance?
Coverage varies by insurer and policy. We provide direct billing verification with major UAE insurance providers — contact our team via WhatsApp at +971 54 548 8731 for a rapid eligibility assessment.
UAE Regulatory & Data Privacy Adherence
Regulatory & Privacy Compliance
This genetic test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, stored securely, and accessed only by authorised clinical personnel. Our facility holds ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | HTRA1 Gene (CARASIL) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Dried Blood Spot (FTA card) |
| Methodology Used | Next-Generation Sequencing (NGS) — Full-gene analysis, Illumina platform, ISO 9001:2015 accredited |
| ICD-10-CM Code | I67.8 |
| LOINC Code | 93721-0 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians