Test Price
2,800 AED✅ Home Collection Available
HRAS Gene Costello Syndrome Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- High Diagnostic Accuracy: 99.9% sensitivity achieved through ISO 9001:2015 accredited NGS processing and stringent bioinformatics pipeline.
- VIP Mobile Phlebotomy & Cold-Chain Home Collection: Available daily from 8 AM to 11 PM across all Emirates, ensuring sample integrity.
- Post-Test Telephonic Consultation: 30-minute clinical guidance by a DHA-licensed Consultant Medical Geneticist.
- Direct Billing Support: Insurance pre-approval and billing verification via WhatsApp +971 54 548 8731 (response within 60 seconds).
Test Overview & Methodology
The HRAS Gene Costello Syndrome Genetic Test employs high-depth next‑generation sequencing (NGS) to detect pathogenic variants in the HRAS gene, providing definitive molecular confirmation of Costello syndrome. This test is validated under DHA standards and serves as a cornerstone for early intervention and cascade family screening. A mandatory pre-test genetic counselling session is required to draw a pedigree chart and obtain informed consent.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Method | NGS (Illumina platform, 1000× coverage) | Capillary Sanger sequencing, low throughput |
| Diagnostic Sensitivity | 99.9% | ~95% (misses deep intronic and mosaic variants) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Bioinformatics | ACMG/AMP guidelines, AI‑assisted variant classification | Manual curation, limited interpretation |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist registered with DHA (ID: 9294403), I recognize that pursuing genetic answers for a child with dysmorphic features can be emotionally challenging. A positive HRAS result enables precise medical surveillance, including cardiac monitoring and tumor screening. However, a negative result does not exclude other genetic conditions, and all findings must be interpreted alongside the full clinical picture. Family counselling and cascade testing are integral components of this service.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics
⚠️ Important Advisory
Do not stop any prescribed medications or alter your child’s management plan without consulting the referring physician. This genetic test is a diagnostic aid and should not replace a comprehensive clinical evaluation.
Exclusion Criteria & Emergency Red Flags
- Inability to provide a blood/DNA sample after mandatory genetic counselling session.
- Active systemic infection or hemodynamic instability contraindicating home phlebotomy – patient must be clinically stable.
- Emergency Red Flags: If the individual presents with acute respiratory distress, severe feeding difficulties, or sudden cardiac events, seek immediate hospital care; do not delay treatment for genetic test results.
- Costello syndrome carriers have increased tumor risk; any new pain, lump, or neurological change mandates urgent pediatric oncology evaluation.
Patient FAQ & Clinical Guidance
1. What does the HRAS Gene Costello Syndrome NGS Test detect?
This test identifies pathogenic HRAS variants causing Costello syndrome, a rare disorder characterized by failure to thrive, cardiac defects, developmental delay, and cancer predisposition. The analysis covers all coding exons and flanking splice sites with high-depth coverage.
2. How is the test performed in the UAE?
A certified phlebotomist collects a blood sample at your home via temperature‑controlled cold-chain transport. The sample is processed using whole‑exome capture NGS following DHA‑standard protocols, with clinical interpretation provided by our genetics team.
3. What support do I receive after the result?
You receive a 30‑minute telephonic consultation with a DHA‑licensed Consultant Medical Geneticist who explains the report, discusses surveillance and management options, and advises on cascade family screening.
4. Are there any prerequisites before sampling?
Yes. A mandatory genetic counselling session is required to obtain informed consent and draw a three‑generation pedigree. This ensures appropriate test selection and understanding of implications.
UAE Regulatory & Data Privacy Adherence
Data Protection Framework: All genomic data is handled in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient information is pseudonymised, stored on UAE‑based DHA‑audited servers, and accessed only on a need‑to‑know basis with explicit consent.
Clinical Safety: Procedures are conducted under the provisions of Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and consent protocols are strictly followed.
Quality Accreditation: ISO 9001:2015 certified laboratory (Cert. No. INT/EGQ/2509DA/3139). All NGS workflows are externally quality‑assessed by EMQN/GenQA.
Clinical & Logistical Metadata
| Test Name | HRAS Gene Costello Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina platform, 1000× coverage |
| ICD-10-CM Code | Q87.89, Z13.79, Z82.79 |
| LOINC Code | 95721-2 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians