Test Price
2,800 AED✅ Home Collection Available
HFE Gene Hemochromatosis (Classic) Genetic Test in UAE | AED 2,800
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity through ISO 9001:2015 accredited next-generation sequencing (Cert: INT/EGQ/2509DA/3139).
- Logistics Framework: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Post-Test Support: Telephonic clinical guidance from DHA-licensed medical genetics specialists interpreting your results.
- Insurance Verification: Direct billing confirmation via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) assay screens the complete HFE gene coding region for established pathogenic mutations (C282Y, H63D, S65C) and rare single-nucleotide variants responsible for hereditary hemochromatosis. Early molecular diagnosis enables proactive iron monitoring and therapeutic phlebotomy, preventing irreversible damage to the liver, myocardium, pancreatic islets, and joints.
| Feature | Our Test (NGS Panel) | Alternative PCR Assay |
|---|---|---|
| Coverage | Full gene sequencing; detects novel and rare variants | Limited to C282Y and H63D hotspots |
| Methodology | Illumina NGS with dual-index barcoding | Allele-specific PCR or RFLP |
| Turnaround Time | 21–28 calendar days | 7–14 calendar days |
| Interpretation Quality | Comprehensive variant classification per ACMG guidelines with clinical report | Binary presence/absence of two predefined mutations |
| Accepted Specimens | Whole blood, extracted DNA, or dried blood on FTA card | Whole blood or buccal swab |
Physician Insight & Safety Protocols
"A positive HFE result indicates genetic susceptibility, not a guarantee of severe iron overload. Correlation with serum ferritin, transferrin saturation, and a detailed family pedigree is essential before initiating therapeutic phlebotomy. I always counsel patients that lifestyle modifications—avoiding iron supplements, limiting alcohol, and regular monitoring—can significantly alter disease trajectory. Work closely with your healthcare provider to integrate this genetic information into your complete clinical picture."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Pre-Test Advisory Requirements
- Mandatory pre-test genetic counselling session to document a three-generation pedigree and assess hereditary risk.
- For minors under 18 years: written legal guardian consent is required; testing is performed only when clinically indicated after paediatric specialist evaluation.
- Postpone collection during acute febrile illness to ensure specimen integrity; schedule at least 72 hours after fever resolution.
- No dietary or medication restrictions apply, but please disclose all ongoing therapies to the reporting laboratory.
Exclusion Criteria & Emergency Signs
Seek immediate emergency care if you experience sudden severe epigastric pain, jaundice, haematemesis, metallic taste, or signs of acute iron toxicity. Do not await genetic test results in such scenarios.
Patient FAQ & Clinical Guidance
1. What is the HFE gene hemochromatosis test and why should I consider it?
Snippet: This NGS panel detects HFE mutations linked to hereditary iron overload, enabling early intervention and preventing organ damage.
Hereditary hemochromatosis is an autosomal recessive disorder of iron metabolism. Our test sequences the entire HFE coding region to identify both common pathogenic variants (C282Y, H63D, S65C) and rare variants of uncertain significance. Early detection empowers you to adopt preventive measures—regular blood donation, avoidance of iron supplements and alcohol—preserving liver, cardiac, and pancreatic function.
2. How does this NGS test compare with standard genetic testing for hemochromatosis?
Snippet: NGS provides comprehensive coverage with 99.9% sensitivity versus limited PCR-based methods that miss rare mutations.
Our Illumina platform reads every nucleotide of the HFE gene with deep coverage (≥100×), validated against Sanger sequencing for all variant calls. The bioinformatics pipeline adheres to ACMG/AMP guidelines, ensuring that even low-frequency or novel mutations are reliably reported. Standard PCR assays typically interrogate only two hotspots, yielding higher false-negative rates.
3. What steps should I take if my result is positive for an HFE mutation?
Snippet: A positive result indicates elevated risk; consult your physician for iron studies and a personalised monitoring plan.
First, schedule a follow-up with your primary care physician or a gastroenterologist. They will order serum ferritin, transferrin saturation, and liver function tests. If iron overload is confirmed, therapeutic phlebotomy (regular blood removal) may be initiated. First-degree relatives should consider cascade testing. Maintain a healthy lifestyle—avoid iron-fortified foods, vitamin C megadoses, and alcohol—and monitor regularly.
4. Is home sample collection available for this genetic test?
Snippet: Yes, VIP Mobile Phlebotomy is available daily from 8 AM to 11 PM for standard whole blood specimens.
For peripheral whole blood, serum, or plasma specimens, our temperature-controlled cold-chain home collection service operates seven days a week. A certified phlebotomist visits your residence in Dubai or across the UAE, and samples are transported under strict ISO-compliant conditions to our Dubai Healthcare City laboratory. Extracted DNA or FTA card samples may also be submitted via secure medical courier.
UAE Regulatory & Data Privacy Adherence
Data Protection & Clinical Safety Framework
All genetic data is processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Results are encrypted end-to-end and accessible only to the ordering physician and the patient.
Clinical & Logistical Metadata
| Test Name | HFE Gene Hemochromatosis (Classic) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 21–28 calendar days |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or dried blood spot on FTA card |
| Methodology Used | Next-Generation Sequencing (Illumina platform, dual-index barcoding) |
| ICD-10-CM Code | E83.110 (Hereditary hemochromatosis) |
| LOINC Code | 21665-7 (HFE gene mutation analysis) |
| DHA Facility License & Laboratory Address | DNA Labs UAE, DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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